ArticleSchizophrenia research2014
Low vitamin D levels predict clinical features of schizophrenia.
Article in Schizophrenia research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- Vitamin D as a Modifiable Risk Factor in Schizophrenia a Systematic Review.Biomolecules · 2025Pooled it
- Associations Between Vitamin D Status and Clinical Presentation Among French Inpatients With Substance Use Disorders.Addiction biology · 2026Article
- Diminished social motivation in early psychosis is associated with polygenic liability for low vitamin D.Translational psychiatry · 2024Article
- Establishing associated risk factors, including fungal and parasitic infections among Malaysians living with schizophrenia.Scientific reports · 2024Article
- Sleep Disturbances in Generalized Anxiety Disorder: The Role of Calcium Homeostasis Imbalance.International journal of environmental research and public health · 2023Article
- Nutritional factors associated with aggression.Frontiers in psychiatry · 2023Review
- The Interplay between Vitamin D, Exposure of Anticholinergic Antipsychotics and Cognition in Schizophrenia.Biomedicines · 2022Article
- Impaired spatial memory in adult vitamin D deficient BALB/c mice is associated with reductions in spine density, nitric oxide, and neural nitric oxide synthase in the hippocampus.AIMS neuroscience · 2022Article
- Assessment of the Effects of Dietary Vitamin D Levels on Olanzapine-Induced Metabolic Side Effects: Focus on the Endocannabinoidome-Gut Microbiome Axis.International journal of molecular sciences · 2021Article
- The psychotropic effect of vitamin D supplementation on schizophrenia symptoms.BMC psychiatry · 2021Article
- Higher Dietary Inflammation in Patients with Schizophrenia: A Case-Control Study in Korea.Nutrients · 2021Article
- Nutrition as Metabolic Treatment for Anxiety.Frontiers in psychiatry · 2021Article
- Regulation of Reactive Oxygen Species-Mediated Damage in the Pathogenesis of Schizophrenia.Brain sciences · 2020Review
- Hypovitaminosis D is associated with negative symptoms, suicide risk, agoraphobia, impaired functional remission, and antidepressant consumption in schizophrenia.European archives of psychiatry and clinical neuroscience · 2019Article
- Integrative Transcriptomics Reveals Sexually Dimorphic Control of the Cholinergic/Neurokine Interface in Schizophrenia and Bipolar Disorder.Cell reports · 2019Article
- Symptomatic Correlates of Vitamin D Deficiency in First-Episode Psychosis.Psychiatry journal · 2019Article
- Prevalence and Correlates of Vitamin D Deficiency in a Sample of 290 Inpatients With Mental Illness.Frontiers in psychiatry · 2019Article
- Relationship between serum vitamin D levels and inflammatory markers in acute stroke patients.Brain and behavior · 2018Article
- Holistic Management of Schizophrenia Symptoms Using Pharmacological and Non-pharmacological Treatment.Frontiers in public health · 2018Review
- Upregulation of vitamin D-related genes in schizophrenic patients.Neuropsychiatric disease and treatment · 2018Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
Vitamin D plays crucial roles in neuroprotection and neurodevelopment, and low levels are commonly associated with schizophrenia. We considered if the association was spurious or causal by examining the association of Vitamin D with Leukocyte Telomere Length (LTL), a marker of cellular aging. Vitamin D levels in 22 well-characterized schizophrenia cases were examined with respect to symptoms, cognition, and functioning. LTL was assessed using quantitative polymerase chain reaction (qPCR). The results showed that 91% (20) had deficient or insufficient Vitamin D levels, which were associated with excitement and grandiosity, social anhedonia, and poverty of speech. Sex-specific analyses showed strong associations of hypovitamintosis D to negative symptoms and decreased premorbid adjustment in males, and to lesser hallucinations and emotional withdrawal, but increased anti-social aggression in females. In females LTL was furthermore associated with Vitamin D levels. This study demonstrates a relationship of low vitamin D levels with increased cellular aging in females. It is also the first study to demonstrate potential sex-specific profiles among schizophrenia cases with hypovitaminosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.