ArticleJournal of clinical pathology1989
Detection of T cells in paraffin wax embedded tissue using antibodies against a peptide sequence from the CD3 antigen.
Article in Journal of clinical pathology, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed, 184 citations in OpenAlex.
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- Liposome-mediated CFTR gene transfer to the nasal epithelium of patients with cystic fibrosis.Nature medicine · 1995Trial
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- Histone H1.2 promotes hepatocarcinogenesis by regulating signal transducer and activator of transcription 3 signaling.Cancer science · 2022Article
- Review
- Immune Cell Infiltration and the Expression of PD-1 and PD-L1 in Primary PDGFRA-Mutant Gastrointestinal Stromal Tumors.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2021Article
- Subarachnoid Hemorrhage Induces Dynamic Immune Cell Reactions in the Choroid Plexus.Frontiers in cellular neuroscience · 2020Article
- Epitope recognition in the human-pig comparison model on fixed and embedded material.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2015Article
- Immune cells in primary and metastatic gastrointestinal stromal tumors (GIST).International journal of clinical and experimental pathology · 2014Article
- Primary diffuse large B-cell lymphoma in the anterior hard palate: A rare case report with review of literature.Journal of oral and maxillofacial pathology : JOMFP · 2014Article
- Distribution, organization and innervation of gastric MALT in conventional piglet.Journal of anatomy · 2011Article
- Primary diffuse large B-cell lymphoma of the oral cavity: germinal center classification.Head and neck pathology · 2010Article
- Defects in actin dynamics lead to an autoinflammatory condition through the upregulation of CXCL5.PloS one · 2008Article
- TGF-beta1 suppresses T cell infiltration and VP2 puff B mutation enhances apoptosis in acute polioencephalitis induced by Theiler's virus.Journal of neuroimmunology · 2007Article
- Sequential polymicrobial infections lead to CNS inflammatory disease: possible involvement of bystander activation in heterologous immunity.Journal of neuroimmunology · 2007Article
- Identification of major cell types in paraffin sections of bovine tissues.BMC veterinary research · 2006Article
- Massive apoptosis in lymphoid organs in animal models for primary and secondary progressive multiple sclerosis.The American journal of pathology · 2005Article
- Axonal injury heralds virus-induced demyelination.The American journal of pathology · 2003Article
- Histological and immunohistological investigation of the lymphoid tissue in normal and mycobacteria-affected specimens of the Rufous Hare-wallaby (Lagorchestes hirsutus).Journal of anatomy · 2003Article
- Immunohistochemistry of the lymphoid tissues of the tammar wallaby, Macropus eugenii.Journal of anatomy · 2002Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Rabbit polyclonal antibodies were raised against a proline rich, peptide sequence, comprising 13 amino acids, in the cytoplasmic domain of the CD3 epsilon chain. Immunoprecipitation experiments showed that this antibody preparation recognised the CD3 antigen on human T lymphoblasts. The antibody stained normal T cells strongly in tissue sections which had been fixed in formalin or Bouin's solution and embedded in paraffin wax. Its reactivity with T cell lymphoma, when evaluated on a series of 96 previously phenotyped cases, closely agreed with the results obtained on cryostat sections. These results indicate that the specific detection of T cells in routinely processed tissue biopsy specimens is now technically feasible on a wide scale in diagnostic laboratories using CD3 peptide antibodies, and they also suggest that in future the use of anti-peptide antibodies may detect other lineage specific antigenic markers in paraffin wax sections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.