Trial reportThe American journal of tropical medicine and hygiene2014
Impact of a spatial repellent on malaria incidence in two villages in Sumba, Indonesia.
3 registry-linked trialsOpen access · bronzeAbstract readRandomized Controlled Trial
In one paragraph
Trial report in The American journal of tropical medicine and hygiene, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 61 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 4 pooled it
6.4field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Cluster Randomized Trial of the Efficacy of a Spatial Repellent (the Envelope) on Plasmodium Falciparum Malaria Incidence as Measured by Time to First Infection in Western Kenya
Spatial Repellent Products for Control of Vector Borne Diseases
A Cluster Randomized, Placebo Control Trial to Evaluate the Efficacy of a Spatial Repellent (Mosquito ShieldTM) Against Aedes-borne Virus Infection Among Children ≥ 4-16 Years of Age in the Gampaha District, Sri Lanka
Who cites it
61 citing papers in PubMed, 4 syntheses or guidelines pooled it, 112 citations in OpenAlex.
- Efficacy of volatile pyrethroid spatial repellents to reduce exposure to mosquito and sand fly vectors and human infection risk: a systematic review and meta-analysis.Parasites & vectors · 2026Pooled it
- Volatile pyrethroid spatial repellents for preventing mosquito bites: a systematic review and meta-analysis.EBioMedicine · 2025Pooled it
- Reducing mosquito-borne disease transmission to humans: A systematic review of cluster randomised controlled studies that assess interventions other than non-targeted insecticide.PLoS neglected tropical diseases · 2021Pooled it
- Mosquito repellents for malaria prevention.The Cochrane database of systematic reviews · 2018Pooled it
- Efficacy of a spatial repellent for control ofProceedings of the National Academy of Sciences of the United States of America · 2022Trial
- Impact of a spatial repellent product on Anopheles and non-Anopheles mosquitoes in Sumba, Indonesia.Malaria journal · 2022Trial
- Efficacy of a Spatial Repellent for Control of Malaria in Indonesia: A Cluster-Randomized Controlled Trial.The American journal of tropical medicine and hygiene · 2020Trial
- Article
- Knowledge, attitudes, and practices related to spatial repellent for mosquito control and malaria risk perception in East Sumba, Indonesia.PLOS global public health · 2026Article
- Community perceptions and acceptance of ivermectin for malaria control on Sumba Island, Indonesia.PloS one · 2026Article
- Molecular markers of reduced behavioral sensitivity to transfluthrin in Anopheles gambiae s.s. from Western Kenya.BMC genomics · 2025Article
- Article
- Gaps in protection to Anopheles exposure in high malaria endemic regencies of Papua Province, Indonesia.PloS one · 2025Article
- Article
- Addressing challenges in vector control: a review of current strategies and the imperative for novel tools in India's combat against vector-borne diseases.BMJ public health · 2024Review
- Impact of a spatial repellent intervention on Anopheles kdr insecticide resistance allele in Sumba, Indonesia.Malaria journal · 2024Article
- Case Series of Primaquine-Induced Haemolytic Events in Controlled Trials with G6PD Screening.Pathogens (Basel, Switzerland) · 2023Article
- Article
- Spatial repellents: The current roadmap to global recommendation of spatial repellents for public health use.Current research in parasitology & vector-borne diseases · 2023Article
- Human and vector behaviors determine exposure to Anopheles in Namibia.Parasites & vectors · 2022Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 1 institution in 1 country.
Din SyafruddinEijkman Institute for Molecular Biology, Jakarta, Indonesia; Department of Parasitology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Public Health and Malaria Control, International SOS, Kuala Kencana, Papua Indonesia; Department of Entomology, Faculty of Agriculture, Kasetsart University, Bangkok 10900, Thailand; Department of Epidemiology, Faculty of Public Health, Hasanuddin University, Makassar, Indonesia; Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia; The Sumba Foundation, Bali, Indonesia; Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland; Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana; Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom din@eijkman.go.id.
Michael J BangsEijkman Institute for Molecular Biology, Jakarta, Indonesia; Department of Parasitology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Public Health and Malaria Control, International SOS, Kuala Kencana, Papua Indonesia; Department of Entomology, Faculty of Agriculture, Kasetsart University, Bangkok 10900, Thailand; Department of Epidemiology, Faculty of Public Health, Hasanuddin University, Makassar, Indonesia; Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia; The Sumba Foundation, Bali, Indonesia; Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland; Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana; Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Dian SidikEijkman Institute for Molecular Biology, Jakarta, Indonesia; Department of Parasitology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Public Health and Malaria Control, International SOS, Kuala Kencana, Papua Indonesia; Department of Entomology, Faculty of Agriculture, Kasetsart University, Bangkok 10900, Thailand; Department of Epidemiology, Faculty of Public Health, Hasanuddin University, Makassar, Indonesia; Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia; The Sumba Foundation, Bali, Indonesia; Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland; Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana; Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Iqbal ElyazarEijkman Institute for Molecular Biology, Jakarta, Indonesia; Department of Parasitology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Public Health and Malaria Control, International SOS, Kuala Kencana, Papua Indonesia; Department of Entomology, Faculty of Agriculture, Kasetsart University, Bangkok 10900, Thailand; Department of Epidemiology, Faculty of Public Health, Hasanuddin University, Makassar, Indonesia; Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia; The Sumba Foundation, Bali, Indonesia; Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland; Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana; Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Puji B S AsihEijkman Institute for Molecular Biology, Jakarta, Indonesia; Department of Parasitology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Public Health and Malaria Control, International SOS, Kuala Kencana, Papua Indonesia; Department of Entomology, Faculty of Agriculture, Kasetsart University, Bangkok 10900, Thailand; Department of Epidemiology, Faculty of Public Health, Hasanuddin University, Makassar, Indonesia; Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia; The Sumba Foundation, Bali, Indonesia; Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland; Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana; Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Krisin ChanEijkman Institute for Molecular Biology, Jakarta, Indonesia; Department of Parasitology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Public Health and Malaria Control, International SOS, Kuala Kencana, Papua Indonesia; Department of Entomology, Faculty of Agriculture, Kasetsart University, Bangkok 10900, Thailand; Department of Epidemiology, Faculty of Public Health, Hasanuddin University, Makassar, Indonesia; Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia; The Sumba Foundation, Bali, Indonesia; Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland; Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana; Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Siti NurleilaEijkman Institute for Molecular Biology, Jakarta, Indonesia; Department of Parasitology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Public Health and Malaria Control, International SOS, Kuala Kencana, Papua Indonesia; Department of Entomology, Faculty of Agriculture, Kasetsart University, Bangkok 10900, Thailand; Department of Epidemiology, Faculty of Public Health, Hasanuddin University, Makassar, Indonesia; Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia; The Sumba Foundation, Bali, Indonesia; Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland; Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana; Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Christian NixonEijkman Institute for Molecular Biology, Jakarta, Indonesia; Department of Parasitology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Public Health and Malaria Control, International SOS, Kuala Kencana, Papua Indonesia; Department of Entomology, Faculty of Agriculture, Kasetsart University, Bangkok 10900, Thailand; Department of Epidemiology, Faculty of Public Health, Hasanuddin University, Makassar, Indonesia; Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia; The Sumba Foundation, Bali, Indonesia; Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland; Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana; Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Joko HendartoEijkman Institute for Molecular Biology, Jakarta, Indonesia; Department of Parasitology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Public Health and Malaria Control, International SOS, Kuala Kencana, Papua Indonesia; Department of Entomology, Faculty of Agriculture, Kasetsart University, Bangkok 10900, Thailand; Department of Epidemiology, Faculty of Public Health, Hasanuddin University, Makassar, Indonesia; Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia; The Sumba Foundation, Bali, Indonesia; Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland; Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana; Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Isra WahidEijkman Institute for Molecular Biology, Jakarta, Indonesia; Department of Parasitology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Public Health and Malaria Control, International SOS, Kuala Kencana, Papua Indonesia; Department of Entomology, Faculty of Agriculture, Kasetsart University, Bangkok 10900, Thailand; Department of Epidemiology, Faculty of Public Health, Hasanuddin University, Makassar, Indonesia; Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia; The Sumba Foundation, Bali, Indonesia; Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland; Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana; Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Hasanuddin IshakEijkman Institute for Molecular Biology, Jakarta, Indonesia; Department of Parasitology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Public Health and Malaria Control, International SOS, Kuala Kencana, Papua Indonesia; Department of Entomology, Faculty of Agriculture, Kasetsart University, Bangkok 10900, Thailand; Department of Epidemiology, Faculty of Public Health, Hasanuddin University, Makassar, Indonesia; Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia; The Sumba Foundation, Bali, Indonesia; Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland; Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana; Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Claus BøghEijkman Institute for Molecular Biology, Jakarta, Indonesia; Department of Parasitology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Public Health and Malaria Control, International SOS, Kuala Kencana, Papua Indonesia; Department of Entomology, Faculty of Agriculture, Kasetsart University, Bangkok 10900, Thailand; Department of Epidemiology, Faculty of Public Health, Hasanuddin University, Makassar, Indonesia; Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia; The Sumba Foundation, Bali, Indonesia; Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland; Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana; Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
John P GriecoEijkman Institute for Molecular Biology, Jakarta, Indonesia; Department of Parasitology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Public Health and Malaria Control, International SOS, Kuala Kencana, Papua Indonesia; Department of Entomology, Faculty of Agriculture, Kasetsart University, Bangkok 10900, Thailand; Department of Epidemiology, Faculty of Public Health, Hasanuddin University, Makassar, Indonesia; Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia; The Sumba Foundation, Bali, Indonesia; Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland; Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana; Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Nicole L AcheeEijkman Institute for Molecular Biology, Jakarta, Indonesia; Department of Parasitology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Public Health and Malaria Control, International SOS, Kuala Kencana, Papua Indonesia; Department of Entomology, Faculty of Agriculture, Kasetsart University, Bangkok 10900, Thailand; Department of Epidemiology, Faculty of Public Health, Hasanuddin University, Makassar, Indonesia; Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia; The Sumba Foundation, Bali, Indonesia; Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland; Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana; Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
J Kevin BairdEijkman Institute for Molecular Biology, Jakarta, Indonesia; Department of Parasitology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Public Health and Malaria Control, International SOS, Kuala Kencana, Papua Indonesia; Department of Entomology, Faculty of Agriculture, Kasetsart University, Bangkok 10900, Thailand; Department of Epidemiology, Faculty of Public Health, Hasanuddin University, Makassar, Indonesia; Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia; The Sumba Foundation, Bali, Indonesia; Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland; Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana; Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Hasanuddin University · ID
Funding
Wellcome TrustWellcome Trust B9RJIXO
Abstract
A randomized, double-blinded, placebo-controlled study was conducted to examine the effect of spatial repellent (SR) in households at risk of malaria in Indonesia. Following presumptive radical cure for malaria in 180 adult men representing sentinels of new infection in four clusters within two villages, all households were given either metofluthrin or placebo mosquito coils. Weekly blood smear screening and human-landing mosquito catches were done throughout the 6 months intervention. Malaria infections occurred in 61 subjects living in placebo households and 31 subjects living in SR coil households, suggesting a 52% protective effect of SR. Likewise, anopheles indoor human landing rates were 32% lower in homes receiving SR coils. Differences in the malaria attack rate between SR- and placebo-treated homes was significant when not accounting for the effects of clustering. When the analysis was adjusted for intra-cluster correlation, the differences between SR- and placebo-treated homes were not statistically significant. The findings provide evidence of SR public health benefit and support a larger trial statistically powered to detect those effects.
Indexed as
Insect RepellentsCohort StudiesDouble-Blind MethodHumansIndonesiaMalariaPlacebosInsect RepellentsPlacebos
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.