ArticleThe American journal of tropical medicine and hygiene2015
Cryptosporidium muris: infectivity and illness in healthy adult volunteers.
Article in The American journal of tropical medicine and hygiene, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 47 citations in OpenAlex.
- Prevalence and genotype analysis of Cryptosporidium spp. in nine species of wild rodents in China.Parasite (Paris, France) · 2025Article
- Cryptosporidiosis in individuals with inflammatory bowel disease: a scoping review protocol.BMJ open · 2024Article
- Molecular characterization ofFrontiers in veterinary science · 2024Article
- Molecular Detection and Genotyping of Cryptosporidium spp. Isolates from Bats in Colombia.Acta parasitologica · 2023Article
- Microbiome-Metabolomics Analysis of the Impacts ofMicrobiology spectrum · 2023Article
- Detection and Molecular Characterization ofAnimals : an open access journal from MDPI · 2023Article
- Genetic diversity ofJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2022Article
- Intestinal apicomplexan parasitoses among a hospital-based population in Honduras, 2013-2019.Biomedica : revista del Instituto Nacional de Salud · 2021Article
- Article
- Genetic characterizations ofOne health (Amsterdam, Netherlands) · 2021Article
- An Update on ZoonoticAnimals : an open access journal from MDPI · 2021Review
- Opportunities and Challenges in Developing aACS infectious diseases · 2021Article
- Molecular Epidemiology of Human Cryptosporidiosis in Low- and Middle-Income Countries.Clinical microbiology reviews · 2021Review
- Molecular characterization of the waterborne pathogens Cryptosporidium spp., Giardia duodenalis, Enterocytozoon bieneusi, Cyclospora cayetanensis and Eimeria spp. in wastewater and sewage in Guangzhou, China.Parasites & vectors · 2021Article
- An annotated checklist of the eukaryotic parasites of humans, exclusive of fungi and algae.ZooKeys · 2021Article
- Article
- Diversity of Cryptosporidium spp. in wild rodents from the Canary Islands, Spain.Parasites & vectors · 2020Article
- Article
- Evolutionary genomics of anthroponosis in Cryptosporidium.Nature microbiology · 2019Article
- Prevalence and molecular characterization of Cryptosporidium spp. and Giardia duodenalis in deer in Henan and Jilin, China.Parasites & vectors · 2018Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Although Cryptosporidium parvum and C. hominis cause the majority of human cryptosporidiosis cases, other Cryptosporidium species are also capable of infecting humans, particularly when individuals are immunocompromised. Ten C. muris cases have been reported, primarily in human immunodeficiency virus (HIV) -positive patients with diarrhea. However, asymptomatic cases were reported in two HIV-negative children, and in another case, age and immune status were not described. This study examines the infectivity of C. muris in six healthy adults. Volunteers were challenged with 10(5) C. muris oocysts and monitored for 6 weeks for infection and/or illness. All six patients became infected. Two patients experienced a self-limited diarrheal illness. Total oocysts shed during the study ranged from 6.7 × 10(6) to 4.1 × 10(8), and the number was slightly higher in volunteers with diarrhea (2.8 × 10(8)) than asymptomatic shedders (4.4 × 10(7)). C. muris-infected subjects shed oocysts longer than occurred with other species studied in healthy volunteers. Three volunteers shed oocysts for 7 months. Physical examinations were normal, with no reported recurrence of diarrhea or other gastrointestinal complaints. Two persistent shedders were treated with nitazoxanide, and the infection was resolved. Thus, healthy adults are susceptible to C. muris, which can cause mild diarrhea and result in persistent, asymptomatic infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.