ArticleEvolution; international journal of organic evolution2014
Properties of selected mutations and genotypic landscapes under Fisher's geometric model.
Article in Evolution; international journal of organic evolution, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed.
- Origins and breadth of pairwise epistasis in an α-helix of β-lactamase TEM-1.Nature communications · 2026Article
- D-LIM: A neural network for interpretable gene-gene interactions.PLoS computational biology · 2026Article
- Lethal mutagenesis and the transient within-host dynamics of viral adaptation.Virus evolution · 2025Article
- The importance of epistasis in the evolution of viral pathogens.Virus evolution · 2025Review
- Fisher's Geometric Model as a Tool to Study Speciation.Cold Spring Harbor perspectives in biology · 2024Review
- Unpredictability of the Fitness Effects of Antimicrobial Resistance Mutations Across Environments in Escherichia coli.Molecular biology and evolution · 2024Article
- Changing fitness effects of mutations through long-term bacterial evolution.Science (New York, N.Y.) · 2024Article
- Environmental modulation of global epistasis in a drug resistance fitness landscape.Nature communications · 2023Article
- Evolutionary rescue on genotypic fitness landscapes.Journal of the Royal Society, Interface · 2023Article
- A null model for the distribution of fitness effects of mutations.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Epistasis decreases with increasing antibiotic pressure but not temperature.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Article
- Global epistasis on fitness landscapes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Fitness of evolving bacterial populations is contingent on deep and shallow history but only shallow history creates predictable patterns.Proceedings. Biological sciences · 2022Article
- On the incongruence of genotype-phenotype and fitness landscapes.PLoS computational biology · 2022Article
- Bacterial fitness landscapes stratify based on proteome allocation associated with discrete aero-types.PLoS computational biology · 2021Article
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- Idiosyncratic epistasis creates universals in mutational effects and evolutionary trajectories.Nature ecology & evolution · 2020Article
- Extreme Antagonism Arising from Gene-Environment Interactions.Biophysical journal · 2020Article
- Flux, toxicity, and expression costs generate complex genetic interactions in a metabolic pathway.Science advances · 2020Article
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4 authors.
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Abstract
The fitness landscape-the mapping between genotypes and fitness-determines properties of the process of adaptation. Several small genotypic fitness landscapes have recently been built by selecting a handful of beneficial mutations and measuring fitness of all combinations of these mutations. Here, we generate several testable predictions for the properties of these small genotypic landscapes under Fisher's geometric model of adaptation. When the ancestral strain is far from the fitness optimum, we analytically compute the fitness effect of selected mutations and their epistatic interactions. Epistasis may be negative or positive on average depending on the distance of the ancestral genotype to the optimum and whether mutations were independently selected, or coselected in an adaptive walk. Simulations show that genotypic landscapes built from Fisher's model are very close to an additive landscape when the ancestral strain is far from the optimum. However, when it is close to the optimum, a large diversity of landscape with substantial roughness and sign epistasis emerged. Strikingly, small genotypic landscapes built from several replicate adaptive walks on the same underlying landscape were highly variable, suggesting that several realizations of small genotypic landscapes are needed to gain information about the underlying architecture of the fitness landscape.
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