Evidence map›Paper›PMID 25311448›Full record

Article... International Workshop on Pattern Recognition in NeuroImaging. International Workshop on Pattern Recognition in NeuroImaging2014

Multimodal diagnosis of epilepsy using conditional dependence and multiple imputation.

Wesley T Kerr, Eric S Hwang, Kaavya R Raman, Sarah E Barritt, Akash B Patel, Justine M Le, Jessica M Hori, Emily C Davis, Chelsea T Braesch, Emily A Janio and 8 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in ... International Workshop on Pattern Recognition in NeuroImaging. International Workshop on Pattern Recognition in NeuroImaging, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 1 institution in 1 country.

Wesley T KerrDept. of Biomathematics, David Geffen School of Medicine at the University of California, Los Angeles, Semel Institute, 760 Westwood Plaza, Suite 17-369, Los Angeles, California 90095, Telephone: (310) 986-3307 ; Dept. of Psychiatry, Neuropsychiatric Institute, David Geffen School of Medicine at the University of California, Los Angeles, Semel Institute, 760 Westwood Plaza, Suite 17-369, Los Angeles, California 90095.
Eric S HwangDept. of Psychiatry, Neuropsychiatric Institute, David Geffen School of Medicine at the University of California, Los Angeles, Semel Institute, 760 Westwood Plaza, Suite 17-369, Los Angeles, California 90095.
Kaavya R RamanDept. of Psychiatry, Neuropsychiatric Institute, David Geffen School of Medicine at the University of California, Los Angeles, Semel Institute, 760 Westwood Plaza, Suite 17-369, Los Angeles, California 90095.
Sarah E BarrittDept. of Psychiatry, Neuropsychiatric Institute, David Geffen School of Medicine at the University of California, Los Angeles, Semel Institute, 760 Westwood Plaza, Suite 17-369, Los Angeles, California 90095.
Akash B PatelDept. of Psychiatry, Neuropsychiatric Institute, David Geffen School of Medicine at the University of California, Los Angeles, Semel Institute, 760 Westwood Plaza, Suite 17-369, Los Angeles, California 90095.
Justine M LeDept. of Psychiatry, Neuropsychiatric Institute, David Geffen School of Medicine at the University of California, Los Angeles, Semel Institute, 760 Westwood Plaza, Suite 17-369, Los Angeles, California 90095.
Jessica M HoriDept. of Psychiatry, Neuropsychiatric Institute, David Geffen School of Medicine at the University of California, Los Angeles, Semel Institute, 760 Westwood Plaza, Suite 17-369, Los Angeles, California 90095.
Emily C DavisDept. of Psychiatry, Neuropsychiatric Institute, David Geffen School of Medicine at the University of California, Los Angeles, Semel Institute, 760 Westwood Plaza, Suite 17-369, Los Angeles, California 90095.
Chelsea T BraeschDept. of Psychiatry, Neuropsychiatric Institute, David Geffen School of Medicine at the University of California, Los Angeles, Semel Institute, 760 Westwood Plaza, Suite 17-369, Los Angeles, California 90095.
Emily A JanioDept. of Psychiatry, Neuropsychiatric Institute, David Geffen School of Medicine at the University of California, Los Angeles, Semel Institute, 760 Westwood Plaza, Suite 17-369, Los Angeles, California 90095.
Edward P LauDept. of Psychiatry, Neuropsychiatric Institute, David Geffen School of Medicine at the University of California, Los Angeles, Semel Institute, 760 Westwood Plaza, Suite 17-369, Los Angeles, California 90095.
Andrew Y ChoDept. of Psychiatry, Neuropsychiatric Institute, David Geffen School of Medicine at the University of California, Los Angeles, Semel Institute, 760 Westwood Plaza, Suite 17-369, Los Angeles, California 90095.
Ariana AndersonDept. of Psychiatry, Neuropsychiatric Institute, David Geffen School of Medicine at the University of California, Los Angeles, Semel Institute, 760 Westwood Plaza, Suite 17-369, Los Angeles, California 90095.
Daniel H S SilvermanDept. of Molecular & Medical Pharmacology, Ahmanson Translational Imaging Division, David Geffen School of Medicine at the University of California, Los Angeles, Semel Institute, 760 Westwood Plaza, Suite 17-369, Los Angeles, California 90095.
Noriko SalamonDept. of Radiology, David Geffen School of Medicine at the University of California, Los Angeles, Semel Institute, 760 Westwood Plaza, Suite 17-369, Los Angeles, California 90095.
Jerome EngelDept. of Neurology, David Geffen School of Medicine at the University of California, Los Angeles, Semel Institute, 760 Westwood Plaza, Suite 17-369, Los Angeles, California 90095.
John M SternDept. of Neurology, David Geffen School of Medicine at the University of California, Los Angeles, Semel Institute, 760 Westwood Plaza, Suite 17-369, Los Angeles, California 90095.
Mark S CohenDept. of Psychiatry, Neuropsychiatric Institute, David Geffen School of Medicine at the University of California, Los Angeles, Semel Institute, 760 Westwood Plaza, Suite 17-369, Los Angeles, California 90095 ; Dept. of Radiology, David Geffen School of Medicine at the University of California, Los Angeles, Semel Institute, 760 Westwood Plaza, Suite 17-369, Los Angeles, California 90095 ; Dept. of Neurology, David Geffen School of Medicine at the University of California, Los Angeles, Semel Institute, 760 Westwood Plaza, Suite 17-369, Los Angeles, California 90095 ; Dept. of Psychology, Biomedical Physics, Biomedical Engineering, California Nanosystems Institute, David Geffen School of Medicine at the University of California, Los Angeles, Semel Institute, 760 Westwood Plaza, Suite 17-369, Los Angeles, California 90095.
University of California, Los Angeles · US

Funding

UCLA-Caltech Medical Scientist Training ProgramT32GM008042 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI AJIJOLA, OLUJIMI A, DAWSON, DAVID WAYNE · 1985 to 2023
$29.9M
Systems in Integrative BiologyT32GM008185 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHOU, TOM · 1987 to 2022
$4.6M
Comprehensive Training in Neuroimaging Fundamentals and ApplicationsR90DA023422 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI COHEN, MARK STEVEN · 2006 to 2015
$1.7M
Real-Time Automated Detection of Craving States with fMRI and EEGR33DA026109 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI COHEN, MARK STEVEN · 2010 to 2012
$1.7M
Comprehensive Training in Neuroimaging Fundamentals and ApplicationsT90DA022768 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI COHEN, MARK STEVEN · 2006 to 2015
$1.5M
NIDA NIH HHS R33 DA026109NIDA NIH HHS R90 DA023422NIDA NIH HHS T90 DA022768NIGMS NIH HHS T32 GM008042NIGMS NIH HHS T32 GM008185
6 · The paper itself

Abstract

The definitive diagnosis of the type of epilepsy, if it exists, in medication-resistant seizure disorder is based on the efficient combination of clinical information, long-term video-electroencephalography (EEG) and neuroimaging. Diagnoses are reached by a consensus panel that combines these diverse modalities using clinical wisdom and experience. Here we compare two methods of multimodal computer-aided diagnosis, vector concatenation (VC) and conditional dependence (CD), using clinical archive data from 645 patients with medication-resistant seizure disorder, confirmed by video-EEG. CD models the clinical decision process, whereas VC allows for statistical modeling of cross-modality interactions. Due to the nature of clinical data, not all information was available in all patients. To overcome this, we multiply-imputed the missing data. Using a C4.5 decision tree, single modality classifiers achieved 53.1%, 51.5% and 51.1% average accuracy for MRI, clinical information and FDG-PET, respectively, for the discrimination between non-epileptic seizures, temporal lobe epilepsy, other focal epilepsies and generalized-onset epilepsy (vs. chance, p<0.01). Using VC, the average accuracy was significantly lower (39.2%). In contrast, the CD classifier that classified with MRI then clinical information achieved an average accuracy of 58.7% (vs. VC, p<0.01). The decrease in accuracy of VC compared to the MRI classifier illustrates how the addition of more informative features does not improve performance monotonically. The superiority of conditional dependence over vector concatenation suggests that the structure imposed by conditional dependence improved our ability to model the underlying diagnostic trends in the multimodality data.

Identifiers

PMID25311448
PMCPMC4188529
OpenAlexW2005156404

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.