ArticleMolecular psychiatry2015
Vascular hippocampal plasticity after aerobic exercise in older adults.
Article in Molecular psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 205 papers, 12 of them syntheses that pooled it.
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Who cites it
205 citing papers in PubMed, 12 syntheses or guidelines pooled it, 372 citations in OpenAlex.
- Aerobic exercise training effects on hippocampal volume in healthy older individuals: a meta-analysis of randomized controlled trials.GeroScience · 2024Pooled it
- Effects of an exercise intervention on maternal depression, anxiety, and fatigue: a systematic review and meta-analysis.Frontiers in psychology · 2024Pooled it
- Rationale for a Multi-Factorial Approach for the Reversal of Cognitive Decline in Alzheimer's Disease and MCI: A Review.International journal of molecular sciences · 2023Pooled it
- Dance activity interventions targeting cognitive functioning in older adults with mild cognitive impairment: A meta-analysis.Frontiers in psychology · 2022Pooled it
- Physical exercise interventions for perinatal depression symptoms in women: A systematic review and meta-analysis.Frontiers in psychology · 2022Pooled it
- Effect of Physical Exercise on Cognitive Function of Alzheimer's Disease Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trial.Frontiers in psychiatry · 2022Pooled it
- A Critical Systematic Review of Current Evidence on the Effects of Physical Exercise on Whole/Regional Grey Matter Brain Volume in Populations at Risk of Neurodegeneration.Sports medicine (Auckland, N.Z.) · 2021Pooled it
- Exercise interventions preserve hippocampal volume: A meta-analysis.Hippocampus · 2021Pooled it
- Pooled it
- Cerebral changes improved by physical activity during cognitive decline: A systematic review on MRI studies.NeuroImage. Clinical · 2019Pooled it
- Variability of physiological brain perfusion in healthy subjects - A systematic review of modifiers. Considerations for multi-center ASL studies.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2018Pooled it
- Exercise effects on depression: Possible neural mechanisms.General hospital psychiatry · 2017Pooled it
- Long-Term Effects of a 5-Year Randomized Controlled Exercise Trial on Brain Volumes and Cognitive Function in Older Adults: A 4-Year Post-Intervention Follow-Up Study.Sports medicine (Auckland, N.Z.) · 2026Trial
- Trial
- Oxiracetam and physical activity in preventing cognitive decline after stroke: A multicenter, randomized controlled trial.European stroke journal · 2026Trial
- Working memory improvements following supramaximal high-intensity interval training predicted by increased prefrontal cortex activation and leg strength gains.Cerebral cortex (New York, N.Y. : 1991) · 2025Trial
- Cardiovascular risk factors are associated with lower posterior-medial network functional connectivity in older adults.Alzheimer's research & therapy · 2025Trial
- Exercise effects on brain health and learning from minutes to months: The brain EXTEND trial.Contemporary clinical trials · 2024Trial
- The effects of moderate-intensity aerobic exercise on cognitive function in individuals with stroke-induced mild cognitive impairment: a randomized controlled pilot study.Journal of rehabilitation medicine · 2024Trial
- Long-Term Improvement in Hippocampal-Dependent Learning Ability in Healthy, Aged Individuals Following High Intensity Interval Training.Aging and disease · 2024Trial
145 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 3 countries.
Funding
Abstract
Aerobic exercise in young adults can induce vascular plasticity in the hippocampus, a critical region for recall and recognition memory. In a mechanistic proof-of-concept intervention over 3 months, we investigated whether healthy older adults (60-77 years) also show such plasticity. Regional cerebral blood flow (rCBF) and volume (rCBV) were measured with gadolinium-based perfusion imaging (3 Tesla magnetic resonance image (MRI)). Hippocampal volumes were assessed by high-resolution 7 Tesla MRI. Fitness improvement correlated with changes in hippocampal perfusion and hippocampal head volume. Perfusion tended to increase in younger, but to decrease in older individuals. The changes in fitness, hippocampal perfusion and volume were positively related to changes in recognition memory and early recall for complex spatial objects. Path analyses indicated that fitness-related changes in complex object recognition were modulated by hippocampal perfusion. These findings indicate a preserved capacity of the aging human hippocampus for functionally relevant vascular plasticity, which decreases with progressing age.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.