Evidence map›Paper›PMID 25311333›Full record

ArticleThe journal of sexual medicine2015

Addressing sexual dysfunction after risk-reducing salpingo-oophorectomy: effects of a brief, psychosexual intervention.

Sharon L Bober, Christopher J Recklitis, Jennifer Bakan, Judy E Garber, Andrea F Patenaude

Open access · greenAbstract readEvaluation Study
In one paragraph

Article in The journal of sexual medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 4 pooled it
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 4 syntheses or guidelines pooled it, 76 citations in OpenAlex.

  1. Effectiveness of psychoeducation intervention among women with gynecological cancer: a systematic review and meta-analysis of randomized controlled trials.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
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  17. How does genetic testing influence anxiety, depression, and quality of life? A hereditary breast and ovarian cancer syndrome suspects trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021
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  19. Patient interest in the Lowdown on Down There: attendance at a vulvovaginal and sexual health workshop post-cancer treatment.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Sharon L BoberDana-Farber Cancer Institute, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
Christopher J Recklitis
Jennifer Bakan
Judy E Garber
Andrea F Patenaude
Dana-Farber Cancer Institute · USHarvard University · US

Funding

The High Cost of Risk Reduction: Addressing Sexual Dysfunction after OophorectomyR03CA153815 · NCI · DANA-FARBER CANCER INST · PI BOBER, SHARON L. · 2011 to 2012
$175k
NCI NIH HHS 1 R03 CA153815-01A1NCI NIH HHS R03 CA153815
6 · The paper itself

Abstract

introductionWomen at high risk for ovarian cancer due to BRCA1 or BRCA2 mutation or family history are recommended to undergo risk-reducing salpingo-oophorectomy (RRSO) after age 35 or completion of childbearing. This potentially life-saving surgery leads to premature menopause, frequently resulting in distressing and unaddressed sexual dysfunction.

aimTo pilot a novel sexual health intervention for women with BRCA1/2 mutations who previously underwent RRSO a using a single-arm trial. Feasibility and primary outcomes including sexual dysfunction and psychological distress were assessed.

methodsThis single-arm trial included a one-time, half-day educational session comprised of targeted sexual health education, body awareness and relaxation training, and mindfulness-based cognitive therapy strategies, followed by two sessions of tailored telephone counseling. Assessments were completed at baseline and 2 months postintervention.

main outcome measureStudy end points include feasibility and effectiveness as reported by the participant.

resultsThirty-seven women completed baseline and postintervention assessments. At baseline, participants had a mean age of 44.4 (standard deviation [SD] = 3.9) years and mean duration of 3.8 (SD = 2.7) years since RRSO. Overall sexual functioning (P = 0.018), as well as desire (P = 0.003), arousal (P = 0.003), satisfaction (P = 0.028), and pain (P = 0.018), improved significantly. There were significant reductions in somatization (P = 0.029) and anxiety scores (P < 0.001), and, overall, for the Global Severity Index (P < 0.001) of the Brief Symptom Inventory. Sexual self-efficacy and sexual knowledge also improved significantly from baseline to postintervention (both P < 0.001). Women were highly satisfied with the intervention content and reported utilizing new skills to manage sexual dysfunction.

conclusionsThis intervention integrates elements of cognitive behavioral therapy with sexual health education to address a much-neglected problem after RRSO. Results from this promising single-arm study provide preliminary data to move toward conducting a randomized, controlled trial.

Indexed as

Cognitive Behavioral TherapyDirective CounselingOvariectomyRisk Reduction BehaviorSalpingectomyAdultBRCA1 ProteinBRCA2 ProteinFeasibility StudiesFemaleGenetic Predisposition to DiseaseHumansMutationOvarian NeoplasmsPersonal SatisfactionPilot ProjectsBRCA1 ProteinBRCA1 protein, humanBRCA2 ProteinBRCA2 protein, humanQuality of Life and CancerRisk-Reducing Salpingo-Oophorectomy and Sexual DysfunctionSexual Health and Cancer

Identifiers

PMID25311333
PMCPMC4304978
OpenAlexW1546213422

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.