Evidence map›Paper›PMID 25311229›Full record

ReviewNature reviews. Cardiology2015

Coronary microvascular dysfunction: mechanisms and functional assessment.

Paolo G Camici, Giulia d'Amati, Ornella Rimoldi

2 registry-linked trialsAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Cardiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 250 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
250citing papers in PubMed, 5 pooled it
21.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03249272 phase4terminatednot on this mapstarted 2017, after this paper: background citation

Microvascular Dysfunction in Nonischemic Cardiomyopathy: Insights From CMR Assessment of Coronary Flow Reserve

TypeinterventionalSponsorDuke UniversityRan2017 to 2019Enrolled31ConditionsHypertrophic Cardiomyopathy, Non-ischemic Dilated Cardiomyopathy, Microvascular Ischaemia of MyocardiumArmsRegadenoson, Adenosine
NCT05760157 unknown statusnot on this mapstarted 2023, after this paper: background citation

To Establish a Multimodal Dynamic Risk Assessment System of Heart Failure in Patients With Myocardial Infarction Based on Coronary Microcirculation.

TypeobservationalSponsorJian LiuRan2023 to 2025Enrolled567ConditionsHeart Failure, Acute Myocardial InfarctionArmsPossible risk factors of heart failure
3 · Its place in the literature

Who cites it

250 citing papers in PubMed, 5 syntheses or guidelines pooled it, 484 citations in OpenAlex.

  1. Pooled it
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  6. Reproducibility of bolus versus continuous thermodilution for assessment of coronary microvascular function in patients with ANOCA.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2023
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  17. Coronary microvascular dysfunction: a narrative review.Cardiovascular diagnosis and therapy · 2026
    Review
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190 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Paolo G CamiciVita Salute University and Scientific Institute San Raffaele, Via Olgettina, 58, 20132 Milano, Italy.
Giulia d'AmatiDepartment of Radiology, Oncology and Pathology, "Sapienza" Università di Roma, Policlinico Umberto I, Viale Regina Elena, 324, 00161 Rome, Italy.
Ornella RimoldiCNR IBFM, Via Fratelli Cervi, 93, 20090 Segrate (MI), Italy.
Institute of Molecular Bioimaging and Physiology · ITPoliclinico Umberto I · ITVita-Salute San Raffaele University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obstructive disease of the epicardial coronary arteries was recognized as the cause of angina pectoris >2 centuries ago, and sudden thrombotic occlusion of an epicardial coronary artery has been established as the cause of acute myocardial infarction for >100 years. In the past 2 decades, dysfunction of the coronary microvasculature emerged as an additional mechanism of myocardial ischaemia that bears important prognostic implications. The coronary microvasculature (vessels <300 μm in diameter) cannot be directly imaged in vivo, but a number of invasive and noninvasive techniques, each with relative advantages and pitfalls, can be used to assess parameters that depend directly on coronary microvascular function. These methods include invasive or noninvasive measurement of Doppler-derived coronary blood flow velocity reserve, assessment of myocardial blood flow and flow reserve using noninvasive imaging, and calculation of microcirculatory resistance indexes during coronary catheterization. These advanced techniques for assessment of the coronary microvasculature have provided novel insights into the pathophysiological role of coronary microvascular dysfunction in the development of myocardial ischaemia in different clinical conditions.

Indexed as

Blood Flow VelocityCoronary CirculationCoronary VesselsEchocardiography, DopplerHumansMagnetic Resonance ImagingMicrocirculationPositron-Emission TomographyTomography, X-Ray Computed

Identifiers

PMID25311229
OpenAlexW2012434367

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.