ArticleLab on a chip2014
Miniaturized, multiplexed readout of droplet-based microfluidic assays using time-domain modulation.
Article in Lab on a chip, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Advances in Microfluidics Techniques for Rapid Detection of Pesticide Residues in Food.Foods (Basel, Switzerland) · 2023Review
- A Facile Strategy for Visualizing and Modulating Droplet-Based Microfluidics.Micromachines · 2019Article
- Mobile platform for rapid sub-picogram-per-milliliter, multiplexed, digital droplet detection of proteins.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Luminescent nanomaterials for droplet tracking in a microfluidic trapping array.Analytical and bioanalytical chemistry · 2019Article
- FluoroCellTrack: An algorithm for automated analysis of high-throughput droplet microfluidic data.PloS one · 2019Article
- High-Throughput Optofluidic Acquisition of Microdroplets in Microfluidic Systems.Micromachines · 2018Review
- Smartphone-enabled optofluidic exosome diagnostic for concussion recovery.Scientific reports · 2016Article
- Digital PCR using micropatterned superporous absorbent array chips.The Analyst · 2016Article
- Compact and modular multicolour fluorescence detector for droplet microfluidics.Lab on a chip · 2015Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors.
Funding
Abstract
Recent advances in microfluidics to generate and control picoliter emulsions of water in oil have enabled ultra-sensitive assays for small molecules, proteins, nucleic acids, and cells. Unfortunately, the conventional fluorescence detection used to measure the outcome of these droplet-based assays has not proven suited to match the time and space multiplexing capabilities of microfluidic systems. To address this challenge, we developed an in-flow fluorescence detection platform that enables multiple streams of droplets to be monitored using only a single photodetector and no lenses. The key innovation of our technology is the amplitude modulation of the signal from fluorescent droplets using distinct micro-patterned masks for each channel. By taking advantage of the high bandwidth of electronics, our technique enables the velocity-independent recovery of weak fluorescent signals (SNR ≪ 1) using only simple hardware, obviating the need for lasers, bulky detectors, and complex fluid control. We demonstrated a handheld-sized device that simultaneously monitors four independent channels with the capability to be scaled-up to more than sixteen, limited primarily by the droplet density.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.