Evidence map›Paper›PMID 25310910›Full record

ArticleEuropean journal of pharmacology2014

Role of mitogen-activated protein kinase phosphatase-1 in corticosteroid insensitivity of chronic oxidant lung injury.

Mariona Pinart, Farhana Hussain, Sima Shirali, Feng Li, Jie Zhu, Andrew R Clark, Alaina J Ammit, Kian Fan Chung

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of pharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Pathological Mechanism and Targeted Drugs of COPD.International journal of chronic obstructive pulmonary disease · 2022
    Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. Ozone exposure effect on systemic prostaglandin FProstaglandins, leukotrienes, and essential fatty acids · 2017
    Article
  8. Review
  9. Article
  10. Understanding how long-acting βBritish journal of pharmacology · 2016
    Review
  11. Inflammasome, IL-1 and inflammation in ozone-induced lung injury.American journal of clinical and experimental immunology · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Mariona PinartExperimental Studies Unit, Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, UK.
Farhana HussainExperimental Studies Unit, Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, UK.
Sima ShiraliExperimental Studies Unit, Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, UK.
Feng LiExperimental Studies Unit, Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, UK.
Jie ZhuExperimental Studies Unit, Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, UK.
Andrew R ClarkKennedy Institute of Rheumatology Division, Imperial College London, London, UK.
Alaina J AmmitRespiratory Research Group, Faculty of Pharmacy, University of Sydney, NSW, Australia.
Kian Fan ChungExperimental Studies Unit, Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, UK. Electronic address: f.chung@imperial.ac.uk.
Imperial College London · GBUniversity of Sydney · AU

Funding

Versus Arthritis 19614Wellcome TrustWellcome Trust 083905
6 · The paper itself

Abstract

Oxidative stress plays an important role in the pathogenesis of chronic obstructive pulmonary disease (COPD) and in the induction of corticosteroid (CS) insensitivity. Chronic ozone exposure leads to a model of COPD with lung inflammation and emphysema. Mitogen-activated protein kinase phosphatase-1 (MKP-1) may underlie CS insensitivity in COPD. We determined the role played by MKP-1 by studying the effect of corticosteroids in wild-type C57/BL6J and MKP-1(-/-) mice after chronic ozone exposure. Mice were exposed to ozone (3 ppm, 3 h) 12 times over 6 weeks. Dexamethasone (0.1 or 2 mg/kg; intraperitoneally) was administered before each exposure. Mice were studied 24 h after final exposure. In ozone-exposed C57/BL6J mice, bronchial hyperresponsiveness (BHR) was not inhibited by both doses of dexamethasone, but in MKP-1(-/-) mice, there was a small inhibition by high dose dexamethasone (2 mg/kg). There was an increase in mean linear intercept after chronic ozone exposure in both strains which was CS-insensitive. There was lesser inflammation after low dose of dexamethasone in MKP-1(-/-) mice compared to C57/Bl6J mice. Epithelial and collagen areas were modulated in ozone-exposed MKP-1(-/-) mice treated with dexamethasone compared to C57/Bl6J mice. MKP-1 regulated the expression of MMP-12, IL-13 and KC induced by ozone but did not alter dexamethasone׳s effects. Bronchial hyperresponsiveness, lung inflammation and emphySEMa after chronic exposure are CS-insensitive, and the contribution of MKP-1 to CS sensitivity in this model was negligible.

Indexed as

Adrenal Cortex HormonesAnimalsBronchial HyperreactivityDexamethasoneDual Specificity Phosphatase 1InflammationInterleukin-13Lung InjuryMaleMatrix Metalloproteinase 12MiceMice, Inbred C57BLOxidantsOxidative StressOzonePulmonary Disease, Chronic ObstructiveAdrenal Cortex HormonesDexamethasoneDual Specificity Phosphatase 1Dusp1 protein, mouseInterleukin-13Matrix Metalloproteinase 12OxidantsOzoneBronchial hyperresponsivenessEmphysemaLung inflammationMitogen-activated protein kinase phosphatase 1 (MKP-1)Ozone exposure

Identifiers

PMID25310910
PMCPMC4266539
OpenAlexW2136546316

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.