ArticleThe EMBO journal1989
Alternating purine-pyrimidine tracts may promote chromosomal translocations seen in a variety of human lymphoid tumours.
Article in The EMBO journal, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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53 citing papers in PubMed, 156 citations in OpenAlex.
- The remodeling of Z-DNA in the mammalian germ line.Biochemical Society transactions · 2022Article
- Activation of recombinational repair in Ewing sarcoma cells carrying EWS-FLI1 fusion gene by chromosome translocation.Scientific reports · 2022Article
- Viral-mediated activation and inhibition of programmed cell death.PLoS pathogens · 2022Review
- Z-DNA is remodelled by ZBTB43 in prospermatogonia to safeguard the germline genome and epigenome.Nature cell biology · 2022Article
- Zscan4 binds nucleosomal microsatellite DNA and protects mouse two-cell embryos from DNA damage.Science advances · 2020Article
- Article
- DNA secondary structure at chromosomal fragile sites in human disease.Current genomics · 2015Article
- The LMO2 -25 Region Harbours GATA2-Dependent Myeloid Enhancer and RUNX-Dependent T-Lymphoid Repressor Activity.PloS one · 2015Article
- Impact of alternative DNA structures on DNA damage, DNA repair, and genetic instability.DNA repair · 2014Review
- Searching for non-B DNA-forming motifs using nBMST (non-B DNA motif search tool).Current protocols in human genetics · 2012Article
- Methods to determine DNA structural alterations and genetic instability.Methods (San Diego, Calif.) · 2009Review
- Target DNA structure plays a critical role in RAG transposition.PLoS biology · 2006Article
- Causes of oncogenic chromosomal translocation.Trends in genetics : TIG · 2006Review
- Heterogeneous duplications in patients with Pelizaeus-Merzbacher disease suggest a mechanism of coupled homologous and nonhomologous recombination.American journal of human genetics · 2005Article
- Article
- Reciprocal translocations in Saccharomyces cerevisiae formed by nonhomologous end joining.Genetics · 2004Article
- Pax3-FKHR knock-in mice show developmental aberrations but do not develop tumors.Molecular and cellular biology · 2002Article
- Diversity of genomic breakpoints in TFG-ALK translocations in anaplastic large cell lymphomas: identification of a new TFG-ALK(XL) chimeric gene with transforming activity.The American journal of pathology · 2002Article
- V-SINEs: a new superfamily of vertebrate SINEs that are widespread in vertebrate genomes and retain a strongly conserved segment within each repetitive unit.Genome research · 2002Article
- Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chromosomal abnormalities which are prevalent in human lymphoid tumours are believed to be involved in tumour pathogenesis and their formation may be the result of erroneous activity by the V-D-J recombinase. Frequently, recombinase accessibility is provided by prior transcription of the chromosomal regions involved. However, this may not always be so and in those cases DNA structural features must be involved. Here we examine the breakpoints of three different tumour-specific translocations in the proximity of which we can detect no transcription; two of the translocations involve regions of chromosome 11, (t[11;14] [p13;q11] and t[11;14] [q13;q32]), and the third is a newly described translocation, t[7;10] [q35;q24], involving the T cell receptor beta-gene on chromosome 7. In each case, a purine--pyrimidine tract (potential Z-DNA) occurs near the translocation breakpoints. Four independent tumours with translocation t[11;14] [p13;q11] reveal a 2 kb breakpoint cluster region at 11p13 with an adjacent potential Z-DNA region of 62 bp in length; the analogous purine--pyrimidine tract at 10q24 is 32 bp long. The purine--pyrimidine tract at the 11q13 chromosome breakpoint, however, is very large as it covers approximately 800 bp. The position, surrounding sequence and potential Z-DNA tract of the human 11p13 TALLber is conserved in rodents. These results suggest that the purine--pyrimidine tracts, presumably in the Z-DNA form, can influence chromatin structure giving access for recombinase-mediated translocations. Such putative alterations of chromatin organization are supported by the observation of DNase I hypersensitive sites near to translocation breakpoints on 10q24 and 11p13.
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