ArticleThe EMBO journal1989
Human IgG Fc receptor (hFcRII; CD32) exists as multiple isoforms in macrophages, lymphocytes and IgG-transporting placental epithelium.
Article in The EMBO journal, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 159 citations in OpenAlex.
- Plasma protein biomarkers ofFrontiers in cellular and infection microbiology · 2025Article
- Human Liver Macrophage Subsets Defined by CD32.Frontiers in immunology · 2020Article
- Antigenic drift originating from changes to the lateral surface of the neuraminidase head of influenza A virus.Nature microbiology · 2019Article
- The Rare Anaphylaxis-Associated FcγRIIa3 Exhibits Distinct Characteristics From the Canonical FcγRIIa1.Frontiers in immunology · 2018Article
- Polymorphisms and interspecies differences of the activating and inhibitory FcγRII of Macaca nemestrina influence the binding of human IgG subclasses.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Immunoglobulin g (IgG) expression in human umbilical cord endothelial cells.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2011Article
- FcgammaRIIB in autoimmunity and infection: evolutionary and therapeutic implications.Nature reviews. Immunology · 2010Review
- Immune thrombocytopenia in pregnancy.Hematology/oncology clinics of North America · 2009Review
- Signals mediated by FcgammaRIIA suppress the growth of B-lineage acute lymphoblastic leukemia cells.Leukemia · 2002Article
- Ligation of Fc receptor of macrophages stimulates protein kinase C and anti-leishmanial activity.Molecular and cellular biochemistry · 2000Article
- Functions of the Fc receptors for immunoglobulin G.Journal of clinical laboratory analysis · 2000Review
- Expression of placental alkaline phosphatase does not correlate with IgG binding, internalization and transcytosis.The Biochemical journal · 1997Article
- Mapping of bovine FcgammaR (FCGR) genes by sperm typing allows extended use of human map information.Mammalian genome : official journal of the International Mammalian Genome Society · 1997Article
- Syk interacts with tyrosine-phosphorylated proteins in human platelets activated by collagen and cross-linking of the Fc gamma-IIA receptor.The Biochemical journal · 1995Article
- Genetic diversity in human Fc receptor II for immunoglobulin G: Fc gamma receptor IIA ligand-binding polymorphism.Clinical and diagnostic laboratory immunology · 1994Article
- Protein tyrosine kinase activity is essential for Fc gamma receptor-mediated intracellular killing of Staphylococcus aureus by human monocytes.Infection and immunity · 1994Article
- A di-leucine motif mediates endocytosis and basolateral sorting of macrophage IgG Fc receptors in MDCK cells.The EMBO journal · 1994Article
- Ontogeny and distribution of Fc gamma receptors in the human placenta. Transport or immune surveillance?Journal of anatomy · 1994Article
- Fc receptor-mediated signal transduction.Journal of clinical immunology · 1994Review
- Distribution of Fc gamma receptors on trophoblast during human placental development: an immunohistochemical and immunoblotting study.Immunology · 1993Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We previously isolated cDNA clones from a human monocyte library that encoded one member of a family of low-affinity surface receptors for the Fc domain of IgG (hFcRII-A). To investigate possible structural and functional heterogeneity among these receptors, we have now isolated two additional cDNAs (hFcRII-B and hFcRII-C) from a human placental library, placenta being a good source of FcR-bearing macrophages and epithelial cells. Three cDNAs encoded related but distinct transmembrane glycoproteins containing two immunoglobulin-like domains; however, transfected cells produced receptors that were indistinguishable on the basis of ligand binding or reactivity with anti-hFcRII monoclonal antibodies. The sequences of hFcRII-A and -B were most closely related and were identical except for several amino acid substitutions and one small internal deletion. While the ectodomain of hFcRII-C was identical to hFcRII-B, its cytoplasmic tail was unrelated but highly homologous to the corresponding domain of the receptor isoform (mFcRII-B2) found in murine macrophages. Thus, human FcRII may be derived from at least two alternatively spliced genes. Northern blots revealed little difference in the pattern of expression of hFcRII isoforms among various myeloid and lymphoid cells or cell lines. However, the blots--as well as in situ hybridization and immunohistochemistry--demonstrated that hFcRII-C (along with a second monocyte marker, the c-fms encoded CSF-1 receptor) was expressed in placental syncytiotrophoblasts. Since syncytiotrophoblasts comprise the IgG-transporting epithelium of the placental villus, these findings suggest that FcR found in the immune system and in certain epithelia may be structurally or functionally related.
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