ReviewPediatric research2015
Obesity-associated biomarkers and executive function in children.
Review in Pediatric research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04719052 (Mediterranean Enriched Diet for Tackling Youth Obesity), which is not on this map. Cited by 53 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Mediterranean Enriched Diet for Tackling Youth Obesity
Who cites it
53 citing papers in PubMed, 123 citations in OpenAlex.
- Healthy Foundations Study: a randomised controlled trial to evaluate biological embedding of early-life experiences.BMJ open · 2018Trial
- Home-based neuro-cardiac rehabilitation in congenital heart disease: the QUALINEURO-REHAB trial study protocol.BMJ open · 2026Article
- Obesity and Cognitive Function: Leptin Role Through Blood-Brain Barrier and Hippocampus.Molecular neurobiology · 2025Review
- Volumetric brain alterations associated with a high-fat, high-fructose obesogenic diet: Insights from cross-sectional and longitudinal MRI in mice.Biochemical and biophysical research communications · 2025Article
- Association of plasma Irisin levels with executive function in children: the role of weight status.Journal of endocrinological investigation · 2025Article
- Novel brain biomarkers of obesity in young adult women based on statistical measurements of white matter tracts.PloS one · 2025Article
- Predictors of neurodevelopment outcomes among children under 5 years old in Nairobi informal settlements.Frontiers in neuroscience · 2025Article
- Dual Regulation Mechanism of Obesity: DNA Methylation and Intestinal Flora.Biomedicines · 2024Review
- Breastfeeding, Walking Onset, and Abdominal Obesity Are Determinants of Physical Fitness among Latin American and Spanish Schoolchildren: A Cross-Cultural Study.Epidemiologia (Basel, Switzerland) · 2024Article
- Paediatric obesity and metabolic syndrome associations with cognition and the brain in youth: Current evidence and future directions.Pediatric obesity · 2023Review
- Children with lower ratings of executive functions have a greater response to the portion size effect.Appetite · 2023Article
- Is good dietary diversity a predictor of academic success?Acta bio-medica : Atenei Parmensis · 2023Article
- Prenatal environmental exposures associated with sex differences in childhood obesity and neurodevelopment.BMC medicine · 2023Article
- Overweight/obesity and socio-demographic disparities in children's motor and cognitive function.Frontiers in psychology · 2023Article
- Adherence to Screen Time and Physical Activity Guidelines is Associated with Executive Function in US Toddlers Participating in the STRONG Kids 2 Birth Cohort Study.The Journal of pediatrics · 2023Observational
- Metabolism and memory: α-synuclein level in children with obesity and children with type 1 diabetes; relation to glucotoxicity, lipotoxicity and executive functions.International journal of obesity (2005) · 2022Article
- The Association between Stress and Children's Weight Status: A School-Based, Epidemiological Study.Children (Basel, Switzerland) · 2022Article
- Identification of neurodevelopmental transition patterns from infancy to early childhood and risk factors predicting descending transition.Scientific reports · 2022Article
- Normal Weight 6-12 Years Boys Demonstrate Better Cognitive Function and Aerobic Fitness Compared to Overweight Peers.Medicina (Kaunas, Lithuania) · 2022Article
- Longitudinal Associations Between Trauma Exposure and Executive Functions in Children: Findings from a Dutch Birth Cohort Study.Research on child and adolescent psychopathology · 2022Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
There is a growing focus on links between obesity and cognitive decline in adulthood, including Alzheimer's disease. It is also increasingly recognized that obesity in youth is associated with poorer cognitive function, specifically executive functioning skills such as inhibitory control and working memory, which are critical for academic achievement. Emerging literature provides evidence for possible biological mechanisms driven by obesity; obesity-associated biomarkers such as adipokines, obesity-associated inflammatory cytokines, and obesity-associated gut hormones have been associated with learning, memory, and general cognitive function. To date, examination of obesity-associated biology with brain function has primarily occurred in animal models. The few studies examining such biologically mediated pathways in adult humans have corroborated the animal data, but this body of work has gone relatively unrecognized by the pediatric literature. Despite the fact that differences in these biomarkers have been found in association with obesity in children, the possibility that obesity-related biology could affect brain development in children has not been actively considered. We review obesity-associated biomarkers that have shown associations with neurocognitive skills, specifically executive functioning skills, which have far-reaching implications for child development. Understanding such gut-brain associations early in the lifespan may yield unique intervention implications.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.