ArticlePloS one2014
Female reproductive decline is determined by remaining ovarian reserve and age.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Article
- Aging disrupts spatiotemporal coordination in the cycling murine ovary.Nature aging · 2026Article
- Perinatal complications and time to subsequent pregnancy after open, laparoscopic, and hysteroscopic myomectomy: a retrospective cohort study.BMC pregnancy and childbirth · 2026Article
- Likelihood of childbirth in women with one versus two ovaries: a Swedish population-based study of women treated with unilateral oophorectomy for benign indications.Human reproduction open · 2026Article
- Timing and duration of calorie restriction determine its impact on ovarian aging in female mice.npj aging · 2025Article
- HEP14-activated PKC-ERK1/2 pathway boosts HEP14-empowered hADSCs for ovarian regeneration and functional restoration.Communications biology · 2025Article
- Aging Alters mRNA Processing in the Mouse Ovary.Cells · 2025Article
- Ovarian tissue cryopreservation for fertility preservation: a two-decade single-center experience with 451 children and adolescents.Reproductive biology and endocrinology : RB&E · 2025Article
- Unilateral Oophorectomy and Age at Natural Menopause: A Longitudinal Community-Based Cohort Study.BJOG : an international journal of obstetrics and gynaecology · 2025Article
- Article
- Recombinant anti-Mullerian hormone treatment attenuates primordial follicle loss after ovarian cryopreservation and transplantation.Journal of assisted reproduction and genetics · 2023Article
- Effects of Tartrazine on Some Sexual Maturation Parameters in Immature Female Wistar Rats.International journal of environmental research and public health · 2022Article
- Female Reproductive and Gynecologic Considerations in Chronic Kidney Disease: Adolescence and Young Adulthood.Kidney international reports · 2022Review
- Fertility Preservation: How to Preserve Ovarian Function in Children, Adolescents and Adults.Journal of clinical medicine · 2021Review
- Breast Cancer Risk Factors and Circulating Anti-Müllerian Hormone Concentration in Healthy Premenopausal Women.The Journal of clinical endocrinology and metabolism · 2021Article
- Whole Ovary Immunofluorescence, Clearing, and Multiphoton Microscopy for Quantitative 3D Analysis of the Developing Ovarian Reserve in Mouse.Journal of visualized experiments : JoVE · 2021Article
- Biological Impact of Unilateral Oophorectomy: Does the Number of Ovaries Really Matter?Geburtshilfe und Frauenheilkunde · 2021Article
- Delay in IVF treatment up to 180 days does not affect pregnancy outcomes in women with diminished ovarian reserve.Human reproduction (Oxford, England) · 2020Article
- Ability of human umbilical cord mesenchymal stem cells to repair chemotherapy-induced premature ovarian failure.World journal of stem cells · 2020Article
- State of the Art in Fertility Preservation for Female Patients Prior to Oncologic Therapies.Medicina (Kaunas, Lithuania) · 2020Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The early decline and loss of female fertility in humans and other species represents an evolutionary paradox. Despite being born with a vast stock of oocytes, females encounter an exhaustion of ovarian reserve and sterility half way through their natural lives. Female reproductive ageing has been proposed to proceed as an ongoing decline in ovarian reserve, determined by remaining ovarian follicle number. However, despite extensive modelling, the respective contributions of intra-, inter-, and extra-ovarian signalling have not been fully characterised. It remains unclear whether reproductive ageing progresses simply as a pre-determined function of remaining ovarian follicles, or as an age-dependent process in humans. Here, we have analysed ovarian response to hormonal stimulation in women who have undergone surgical removal of a single ovary, in order to investigate the relative contributions of intra-, inter, and extra-ovarian signalling on reproductive ageing. Our data show that in unilaterally oophorectomised women, ovarian response to follicle stimulating hormone (FSH) declines beyond levels predicted by a total ovarian follicle pool model of reproductive ageing. Maintenance of ovarian function later in reproductive life, despite the removal of half of the total ovarian reserve, suggests a role for an extra-ovarian age-dependent regulation of reproductive decline. This highlights the need for further work to identify signalling factors that communicate age-related signals between the soma and the germline.
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