Evidence map›Paper›PMID 25310650›Full record

ReviewInternational journal of molecular sciences2014

Molecular mechanisms of host cytoskeletal rearrangements by Shigella invasins.

Jun Hyuck Lee, HaJeung Park, Yong Ho Park

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.9field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. International journal of molecular sciences · 2024
    Review
  4. Article
  5. RACK1 promotesiScience · 2023
    Article
  6. Review
  7. Article
  8. Taming the Triskelion: Bacterial Manipulation of Clathrin.Microbiology and molecular biology reviews : MMBR · 2019
    Review
  9. The Role and Mechanism of Erythrocyte Invasion byFrontiers in cellular and infection microbiology · 2017
    Article
  10. PeerJ · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Jun Hyuck LeeDivision of Polar Life Sciences, Korea Polar Research Institute, Incheon 406-840, Korea. junhyucklee@kopri.re.kr.
HaJeung ParkThe Scripps Research Institute, Scripps Florida, 130 Scripps Way, Jupiter, FL 33458, USA. hajpark@scripps.edu.
Yong Ho ParkLaboratory of Veterinary Microbiology, College of Veterinary Medicine, Seoul National University, Seoul 151-742, Korea. yhp@snu.ac.kr.
Korea Polar Research Institute · KRScripps Research Institute · USSeoul National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pathogen-induced reorganization of the host cell cytoskeleton is a common strategy utilized in host cell invasion by many facultative intracellular bacteria, such as Shigella, Listeria, enteroinvasive E. coli and Salmonella. Shigella is an enteroinvasive intracellular pathogen that preferentially infects human epithelial cells and causes bacillary dysentery. Invasion of Shigella into intestinal epithelial cells requires extensive remodeling of the actin cytoskeleton with the aid of pathogenic effector proteins injected into the host cell by the activity of the type III secretion system. These so-called Shigella invasins, including IpaA, IpaC, IpgB1, IpgB2 and IpgD, modulate the actin-regulatory system in a concerted manner to guarantee efficient entry of the bacteria into host cells.

Indexed as

Host-Pathogen InteractionsAmino Acid SequenceAnimalsAntigens, BacterialBacterial ProteinsCytoskeletonDysentery, BacillaryHumansModels, MolecularMolecular Sequence DataShigellaAntigens, BacterialBacterial Proteins

Identifiers

PMID25310650
PMCPMC4227214
OpenAlexW2006224339

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.