ArticlePloS one2014
Detection of the G17V RHOA mutation in angioimmunoblastic T-cell lymphoma and related lymphomas using quantitative allele-specific PCR.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- Real-World Data on the p.Gly17Val RHOA Mutation in Diagnosing T Follicular Helper Cell Lymphomas.Cancer medicine · 2025Article
- How molecular advances may improve the diagnosis and management of PTCL patients.Frontiers in oncology · 2023Review
- Early detection of T-cell lymphoma with T follicular helper phenotype by RHOA mutation analysis.Haematologica · 2022Article
- Neoplasms of follicular helper T-cells: an insight into the pathobiology.American journal of blood research · 2022Review
- Mutation analysis links angioimmunoblastic T-cell lymphoma to clonal hematopoiesis and smoking.eLife · 2021Article
- Application of NanoString technologies in angioimmunoblastic T cell lymphoma.Genes & genomics · 2020Article
- Droplet digital polymerase chain reaction assay and peptide nucleic acid-locked nucleic acid clamp method for RHOA mutation detection in angioimmunoblastic T-cell lymphoma.Cancer science · 2018Article
- STAT5 inhibition induces TRAIL/DR4 dependent apoptosis in peripheral T-cell lymphoma.Oncotarget · 2018Article
- Review of the biologic and clinical significance of genetic mutations in angioimmunoblastic T-cell lymphoma.Cancer science · 2018Review
- [The second generation sequencing technology and its application in the field of hematologic malignancies].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2015Article
- New developments in the pathology of malignant lymphoma: a review of the literature published from October 2014-December 2014.Journal of hematopathology · 2015Review
- Concurrent Mutations in ATM and Genes Associated with Common γ Chain Signaling in Peripheral T Cell Lymphoma.PloS one · 2015Article
- G17V RHOA: Genetic evidence of GTP-unbound RHOA playing a role in tumorigenesis in T cells.Small GTPases · 2015Review
Corrections and comments
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Authors and funding
25 authors at 11 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Angioimmunoblastic T-cell lymphoma (AITL) and peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) are subtypes of T-cell lymphoma. Due to low tumor cell content and substantial reactive cell infiltration, these lymphomas are sometimes mistaken for other types of lymphomas or even non-neoplastic diseases. In addition, a significant proportion of PTCL-NOS cases reportedly exhibit features of AITL (AITL-like PTCL-NOS). Thus disagreement is common in distinguishing between AITL and PTCL-NOS. Using whole-exome and subsequent targeted sequencing, we recently identified G17V RHOA mutations in 60-70% of AITL and AITL-like PTCL-NOS cases but not in other hematologic cancers, including other T-cell malignancies. Here, we establish a sensitive detection method for the G17V RHOA mutation using a quantitative allele-specific polymerase chain reaction (qAS-PCR) assay. Mutated allele frequencies deduced from this approach were highly correlated with those determined by deep sequencing. This method could serve as a novel diagnostic tool for 60-70% of AITL and AITL-like PTCL-NOS.
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