ArticlePloS one2014
Chikungunya viral fitness measures within the vector and subsequent transmission potential.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Recent advances in antiviral drugs for Chikungunya virus (CHIKV): Targets, mechanisms, and development strategies.Acta pharmaceutica Sinica. B · 2026Review
- Estimating the transmissibility of the 2025 chikungunya fever outbreak in Foshan, China: a modelling study.Infectious diseases of poverty · 2025Article
- Intra-vector infection dynamics challenge how to model the extrinsic incubation period for major arboviruses: dengue, Zika, and chikungunya.PLoS computational biology · 2025Article
- Temperature affects viral kinetics and vectorial capacity of Aedes aegypti mosquitoes co-infected with Mayaro and Dengue viruses.Parasites & vectors · 2024Article
- Identifying Knowledge Gaps through the Systematic Review of Temperature-Driven Variability in the Competence ofPathogens (Basel, Switzerland) · 2023Article
- A minimum data standard for vector competence experiments.Scientific data · 2022Article
- Estimating chikungunya virus transmission parameters and vector control effectiveness highlights key factors to mitigate arboviral disease outbreaks.PLoS neglected tropical diseases · 2022Article
- Impact of Irradiation on Vector Competence ofFrontiers in bioengineering and biotechnology · 2022Article
- Past and future epidemic potential of chikungunya virus in Australia.PLoS neglected tropical diseases · 2021Article
- Article
- Identifying the fitness costs of a pyrethroid-resistant genotype in the major arboviral vector Aedes aegypti.Parasites & vectors · 2020Article
- Increased temperatures reduce the vectorial capacity ofEmerging microbes & infections · 2020Article
- Chikungunya Virus Transmission at Low Temperature byPathogens (Basel, Switzerland) · 2019Article
- Local and regional dynamics of chikungunya virus transmission in Colombia: the role of mismatched spatial heterogeneity.BMC medicine · 2018Article
- Temperature drives Zika virus transmission: evidence from empirical and mathematical models.Proceedings. Biological sciences · 2018Article
- Examining the potential for South American arboviruses to spread beyond the New World.Current clinical microbiology reports · 2017Article
- Assessment of the Probability of Autochthonous Transmission of Chikungunya Virus in Canada under Recent and Projected Climate Change.Environmental health perspectives · 2017Article
- Defining the Risk of Zika and Chikungunya Virus Transmission in Human Population Centers of the Eastern United States.PLoS neglected tropical diseases · 2017Article
- Bridging the Gap Between Experimental Data and Model Parameterization for Chikungunya Virus Transmission Predictions.The Journal of infectious diseases · 2016Article
- Co-distribution and co-infection of chikungunya and dengue viruses.BMC infectious diseases · 2016Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Given the recent emergence of chikungunya in the Americas, the accuracy of forecasting and prediction of chikungunya transmission potential in the U.S. requires urgent assessment. The La Reunion-associated sub-lineage of chikungunya (with a valine substitution in the envelope protein) was shown to increase viral fitness in the secondary vector, Ae. albopictus. Subsequently, a majority of experimental and modeling efforts focused on this combination of a sub-lineage of the East-Central-South African genotype (ECSA-V)-Ae. albopictus, despite the Asian genotype being the etiologic agent of recent chikungunya outbreaks world-wide. We explore a collection of data to investigate relative transmission efficiencies of the three major genotypes/sub-lineages of chikungunya and found difference in the extrinsic incubation periods to be largely overstated. However, there is strong evidence supporting the role of Ae. albopictus in the expansion of chikungunya that our R0 calculations cannot attribute to fitness increases in one vector over another. This suggests other ecological factors associated with the Ae. albopictus-ECSA-V cycle may drive transmission intensity differences. With the apparent bias in literature, however, we are less prepared to evaluate transmission where Ae. aegypti plays a significant role. Holistic investigations of CHIKV transmission cycle(s) will allow for more complete assessment of transmission risk in areas affected by either or both competent vectors.
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