Evidence map›Paper›PMID 25309933›Full record

ArticleJournal of immunology research2014

Association of Helicobacter pylori and iNOS production by macrophages and lymphocytes in the gastric mucosa in chronic gastritis.

Lilia A Cherdantseva, Oksana V Potapova, Tatyana V Sharkova, Yana Yu Belyaeva, Vyacheslav A Shkurupiy

Open access · goldAbstract read
In one paragraph

Article in Journal of immunology research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Mitochondrial Stress inAntioxidants (Basel, Switzerland) · 2026
    Review
  3. Strategies ofFrontiers in cellular and infection microbiology · 2024
    Review
  4. GastricInternational journal of molecular sciences · 2021
    Article
  5. Eradication ofFrontiers in microbiology · 2021
    Review
  6. An Overview of Helicobacter pylori Infection.Methods in molecular biology (Clifton, N.J.) · 2021
    Review
  7. Article
  8. Article
  9. Article
  10. Frontiers in microbiology · 2018
    Review
  11. Article
  12. Cooperation of Gastric Mononuclear Phagocytes withJournal of immunology (Baltimore, Md. : 1950) · 2017
    Article
  13. Review
  14. Article
  15. The Metabonomic Studies of Tongue Coating in H. pylori Positive Chronic Gastritis Patients.Evidence-based complementary and alternative medicine : eCAM · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Lilia A CherdantsevaFSBI Research Center of Clinical and Experimental Medicine, SB RAMS, Timakova Street 2, Novosibirsk 630117, Russia.
Oksana V PotapovaFSBI Research Center of Clinical and Experimental Medicine, SB RAMS, Timakova Street 2, Novosibirsk 630117, Russia.
Tatyana V SharkovaFSBI Research Center of Clinical and Experimental Medicine, SB RAMS, Timakova Street 2, Novosibirsk 630117, Russia.
Yana Yu BelyaevaFSBI Research Center of Clinical and Experimental Medicine, SB RAMS, Timakova Street 2, Novosibirsk 630117, Russia.ORCID 0000-0002-6544-5778
Vyacheslav A ShkurupiyFSBI Research Center of Clinical and Experimental Medicine, SB RAMS, Timakova Street 2, Novosibirsk 630117, Russia.ORCID 0000-0002-5078-4216
Scientific Research Institute of Experimental and Clinical Medicine · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Helicobacter pylori is one of the most common causes of chronic gastritis. With the development of the disease cellular inflammatory infiltrates composed of lymphocytes, plasma cells, and macrophages are formed in epithelium and lamina propria of the stomach. These cells are capable of secreting a number of active substances, including inducible nitric oxide synthase (iNOS). We examined the relationship between H. pylori and secretion of iNOS by cells of inflammatory infiltrates in chronic gastritis by light microscopy and immunohistochemistry. The data obtained indicate that stimulation of H. pylori immune system cells of the host organism during development of chronic gastritis causes increase in number of macrophages and lymphocytes in the inflammatory infiltrate of the gastric mucosa. This is accompanied with increased expression of inducible NO-synthase with excess free radicals in the tissues, which leads to secondary alterations and exacerbates the inflammation with impaired regeneration processes.

Indexed as

Cell CountChronic DiseaseGastric MucosaGastritisHelicobacter InfectionsHelicobacter pyloriHost-Pathogen InteractionsHumansImmunohistochemistryLymphocytesMacrophagesMiddle AgedNitric Oxide Synthase Type IINitric Oxide Synthase Type II

Identifiers

PMID25309933
PMCPMC4189519
OpenAlexW1994371028

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.