Evidence map›Paper›PMID 25309927›Full record

ArticleBioMed research international2014

Niosomes of ascorbic acid and α-tocopherol in the cerebral ischemia-reperfusion model in male rats.

Jaleh Varshosaz, Somayeh Taymouri, Abbas Pardakhty, Majid Asadi-Shekaari, Abodolreza Babaee

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Assessment of the antidiabetic potential of extract and novel phytoniosomes formulation of Tradescantia pallida leaves in the alloxan-induced diabetic mouse model.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2023
    Article
  12. Article
  13. Recent advances in nanocarriers for nutrient delivery.Drug delivery and translational research · 2022
    Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Phytoniosome: a Novel Drug Delivery for Myrtle Extract.Iranian journal of pharmaceutical research : IJPR · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jaleh VarshosazDepartment of Pharmaceutics, School of Pharmacy and Novel Drug Delivery Systems Research Centre, Isfahan University of Medical Sciences, P.O. Box 81745-359, Isfahan, Iran.
Somayeh TaymouriPharmaceutics Research Center, Neuropharmacology Institute, Kerman University of Medical Sciences, P.O. Box 76175-493, Kerman, Iran.
Abbas PardakhtyPharmaceutics Research Center, Neuropharmacology Institute, Kerman University of Medical Sciences, P.O. Box 76175-493, Kerman, Iran.
Majid Asadi-ShekaariNeuroscience Research Center, Neuropharmacology Institute, Kerman University of Medical Sciences, Kerman 7619813159, Iran.
Abodolreza BabaeeAnatomical Sciences Department, Afzali Pour Medical Faculty, Kerman University of Medical Sciences, P.O. Box 76175-493, Kerman, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The objective of the present study was to prepare a stable iv injectable formulation of ascorbic acid and α-tocopherol in preventing the cerebral ischemia. Different niosomal formulations were prepared by Span and Tween mixed with cholesterol. The physicochemical characteristics of niosomal formulations were evaluated in vitro. For in vivo evaluation, the rats were made ischemic by middle cerebral artery occlusion model for 30 min and the selected formulation was used for determining its neuroprotective effect against cerebral ischemia. Neuronal damage was evaluated by optical microscopy and transmission electron microscopy. The encapsulation efficiency of ascorbic acid was increased to more than 84% by remote loading method. The cholesterol content of the niosomes, the hydrophilicity potential of the encapsulated compounds, and the preparation method of niosomes were the main factors affecting the mean volume diameter of the prepared vesicles. High physical stability of the niosomes prepared from Span 40 and Span 60 was demonstrated due to negligible size change of vesicles during 6 months storage at 4-8(°)C. In vivo studies showed that ST60/Chol 35 : 35 : 30 niosomes had more neuroprotective effects against cerebral ischemic injuries in male rats than free ascorbic acid.

Indexed as

alpha-TocopherolAnimalsAscorbic AcidBrain IschemiaCerebral CortexChemistry, PharmaceuticalDisease Models, AnimalInfarction, Middle Cerebral ArteryLiposomesMaleNeuronsParticle SizeRats, WistarReperfusion Injuryalpha-TocopherolAscorbic AcidLiposomes

Identifiers

PMID25309927
PMCPMC4163366

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.