Evidence map›Paper›PMID 25309926›Full record

ArticleBioMed research international2014

18FDG, [18F]FLT, [18F]FAZA, and 11C-methionine are suitable tracers for the diagnosis and in vivo follow-up of the efficacy of chemotherapy by miniPET in both multidrug resistant and sensitive human gynecologic tumor xenografts.

György Trencsényi, Teréz Márián, Imre Lajtos, Zoltán Krasznai, László Balkay, Miklós Emri, Pál Mikecz, Katalin Goda, Gábor Szalóki, István Juhász and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
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  4. RepurposingJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2021
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  5. BioMed research international · 2020
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  6. Review
  7. An update on the role of PET/CT and PET/MRI in ovarian cancer.European journal of nuclear medicine and molecular imaging · 2017
    Review
  8. Assessment of Amino Acid/Drug Transporters for Renal Transport of [International journal of molecular sciences · 2016
    Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

György TrencsényiDepartment of Nuclear Medicine, University of Debrecen, P.O. Box 63, Nagyerdei Körút 98, Debrecen 4012, Hungary.
Teréz MáriánDepartment of Nuclear Medicine, University of Debrecen, P.O. Box 63, Nagyerdei Körút 98, Debrecen 4012, Hungary.
Imre LajtosDepartment of Nuclear Medicine, University of Debrecen, P.O. Box 63, Nagyerdei Körút 98, Debrecen 4012, Hungary.
Zoltán KrasznaiDepartment of Biophysics and Cell Biology, University of Debrecen, Nagyerdei Körút 98, Debrecen 4012, Hungary.
László BalkayDepartment of Nuclear Medicine, University of Debrecen, P.O. Box 63, Nagyerdei Körút 98, Debrecen 4012, Hungary.
Miklós EmriDepartment of Nuclear Medicine, University of Debrecen, P.O. Box 63, Nagyerdei Körút 98, Debrecen 4012, Hungary.
Pál MikeczDepartment of Nuclear Medicine, University of Debrecen, P.O. Box 63, Nagyerdei Körút 98, Debrecen 4012, Hungary.
Katalin GodaDepartment of Biophysics and Cell Biology, University of Debrecen, Nagyerdei Körút 98, Debrecen 4012, Hungary.
Gábor SzalókiDepartment of Biophysics and Cell Biology, University of Debrecen, Nagyerdei Körút 98, Debrecen 4012, Hungary.
István JuhászDepartment of Dermatology, University of Debrecen, Nagyerdei Körút 98, Debrecen 4012, Hungary ; Department of Surgery and Operative Techniques, Faculty of Dentistry, University of Debrecen, Nagyerdei Körút 98, Debrecen 4012, Hungary.
Enikő NémethDepartment of Nuclear Medicine, University of Debrecen, P.O. Box 63, Nagyerdei Körút 98, Debrecen 4012, Hungary.
Tünde MikloviczDepartment of Nuclear Medicine, University of Debrecen, P.O. Box 63, Nagyerdei Körút 98, Debrecen 4012, Hungary.
Gábor SzabóDepartment of Biophysics and Cell Biology, University of Debrecen, Nagyerdei Körút 98, Debrecen 4012, Hungary.
Zoárd T KrasznaiDepartment of Obstetrics and Gynecology, University of Debrecen, Nagyerdei Körút 98, Debrecen 4012, Hungary.
University of Debrecen · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Expression of multidrug pumps including P-glycoprotein (MDR1, ABCB1) in the plasma membrane of tumor cells often results in decreased intracellular accumulation of anticancer drugs causing serious impediment to successful chemotherapy. It has been shown earlier that combined treatment with UIC2 anti-Pgp monoclonal antibody (mAb) and cyclosporine A (CSA) is an effective way of blocking Pgp function. In the present work we investigated the suitability of four PET tumor diagnostic radiotracers including 2-[(18)F]fluoro-2-deoxy-D-glucose ((18)FDG), (11)C-methionine, 3'-deoxy-3'-[(18)F]fluorothymidine ((18)F-FLT), and [(18)F]fluoroazomycin-arabinofuranoside ((18)FAZA) for in vivo follow-up of the efficacy of chemotherapy in both Pgp positive (Pgp(+)) and negative (Pgp(-)) human tumor xenograft pairs raised in CB-17 SCID mice. Pgp(+) and Pgp(-) A2780AD/A2780 human ovarian carcinoma and KB-V1/KB-3-1 human epidermoid adenocarcinoma tumor xenografts were used to study the effect of the treatment with an anticancer drug doxorubicin combined with UIC2 and CSA. The combined treatment resulted in a significant decrease of both the tumor size and the accumulation of the tumor diagnostic tracers in the Pgp(+) tumors. Our results demonstrate that (18)FDG, (18)F-FLT, (18)FAZA, and (11)C-methionine are suitable PET tracers for the diagnosis and in vivo follow-up of the efficacy of tumor chemotherapy in both Pgp(+) and Pgp(-) human tumor xenografts by miniPET.

Indexed as

Drug Resistance, MultipleDrug Resistance, NeoplasmPositron-Emission TomographyRadiopharmaceuticalsXenograft Model Antitumor AssaysAnimalsATP Binding Cassette Transporter, Subfamily B, Member 1AutoradiographyCarbon RadioisotopesCell Line, TumorDideoxynucleosidesFemaleFlow CytometryFluorodeoxyglucose F18Follow-Up StudiesGenital Neoplasms, FemalealovudineATP Binding Cassette Transporter, Subfamily B, Member 1Carbon RadioisotopesDideoxynucleosidesfluoroazomycin arabinosideFluorodeoxyglucose F18MethionineNitroimidazolesRadiopharmaceuticals

Identifiers

PMID25309926
PMCPMC4182689
OpenAlexW1980489760

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.