ArticleBioMed research international2014
Collagen-glycosaminoglycan matrix implantation promotes angiogenesis following surgical brain trauma.
Article in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- Therapeutic Effect of Decellularized Extracellular Matrix from Fish Skin for Accelerating Skin Regeneration.Marine drugs · 2024Article
- Glycosaminoglycans Modulate the Angiogenic Ability of Type I Collagen-Based Scaffolds by Acting on Vascular Network Remodeling and Maturation.Bioengineering (Basel, Switzerland) · 2024Article
- Establishment of an Immunocompetent Metastasis Rat Model with Hepatocyte Cancer Stem Cells.Cancers · 2020Article
- Possible role of EphA4 and VEGFR2 interactions in neural stem and progenitor cell differentiation.Experimental and therapeutic medicine · 2020Article
- Effects of Collagen Hydrolysates on Human Brain Structure and Cognitive Function: A Pilot Clinical Study.Nutrients · 2019Article
- Intra-cerebral implantation of a variety of collagenous scaffolds with nervous embryonic cells.Experimental and therapeutic medicine · 2019Article
- Surgically-induced brain injury: where are we now?Chinese neurosurgical journal · 2019Review
- Neuroprotective Effects of Collagen-Glycosaminoglycan Matrix Implantation following Surgical Brain Injury.Mediators of inflammation · 2019Article
- Differential degradation rate and underlying mechanism of a collagen/chitosan complex in subcutis, spinal cord and brain tissues of rat.Journal of materials science. Materials in medicine · 2018Article
- Magnetic resonance imaging-three-dimensional printing technology fabricates customized scaffolds for brain tissue engineering.Neural regeneration research · 2017Article
- Recombinant Slit2 attenuates neuroinflammation after surgical brain injury by inhibiting peripheral immune cell infiltration via Robo1-srGAP1 pathway in a rat model.Neurobiology of disease · 2016Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Surgical brain injury (SBI) is unavoidable during many neurosurgical procedures intrinsically linked to postoperative neurological deficits. We have previously demonstrated that implantation of collagen glycosaminoglycan (CG) following surgical brain injury could significantly promote functional recovery and neurogenesis. In this study we further hypothesized that this scaffold may provide a microenvironment by promoting angiogenesis to favor neurogenesis and subsequent functional recovery. Using the rodent model of surgical brain injury as we previously established, we divided Sprague-Dawley male rats (weighting 300-350 g) into three groups: (1) sham (2) surgical injury with a lesion (L), and (3) L with CG matrix implantation (L + CG). Our results demonstrated that L + CG group showed a statistically significant increase in the density of vascular endothelial cells and blood vessels over time. In addition, tissue concentrations of angiogenic growth factors (such as VEGF, FGF2, and PDGF) significantly increased in L + CG group. These results suggest that implantation of a CG scaffold can promote vascularization accompanied by neurogenesis. This opens prospects for use of CG scaffolds in conditions such as brain injury including trauma and ischemia.
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