Evidence map›Paper›PMID 25309899›Full record

ArticleEndoplasmic reticulum stress in diseases2014

Protein Disulfide Isomerase Superfamily in Disease and the Regulation of Apoptosis.

C Grek, D M Townsend

Open access · bronzeAbstract read
In one paragraph

Article in Endoplasmic reticulum stress in diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 69 citations in OpenAlex.

  1. Article
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  8. Hidden Relationships betweenInternational journal of molecular sciences · 2022
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  12. GlutathioneThe Journal of pharmacology and experimental therapeutics · 2021
    Article
  13. Article
  14. DomesticatedGenes · 2020
    Article
  15. Review
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  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

C GrekDepartment of Cell and Molecular Pharmacology and Experimental Therapeutics.
D M TownsendDrug Discovery and Biomedical Sciences, Medical University of South Carolina, Charleston, SC 29425.
Medical University of South Carolina · US

Funding

SOUTH CAROLINA COBRE IN OXIDANTS, REDOX BALANCE AND STRESS SIGNALINGP20GM103542 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI TEW, KENNETH D. · 2012 to 2020
$20.2M
SOUTH CAROLINA COBRE IN OXIDANTS, REDOX BALANCE AND STRESS SIGNALINGP20RR024485 · NCRR · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI TEW, KENNETH D. · 2011 to 2011
$2.2M
PRECLINICAL DEVELOPMENT OF A GLUTATHIONE BASED CANCER DRUGR41CA117259 · NCI · CELLECTAR BIOSCIENCES, INC. · PI TEW, KENNETH D. · 2007 to 2007
$150k
RNS Mediated Regulation of Protein Disulfide Isomerase in Neuronal CellsR56ES017453 · NIEHS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI TOWNSEND, DANYELLE M. · 2010 to 2010
$108k
NCI NIH HHS R41 CA117259NCRR NIH HHS P20 RR024485NIEHS NIH HHS R56 ES017453NIGMS NIH HHS P20 GM103542
6 · The paper itself

Abstract

Cellular homeostasis requires the balance of a multitude of signaling cascades that are contingent upon the essential proteins being properly synthesized, folded and delivered to appropriate subcellular locations. In eukaryotic cells the endoplasmic reticulum (ER) is a specialized organelle that is the central site of synthesis and folding of secretory, membrane and a number of organelletargeted proteins. The integrity of protein folding is enabled by the presence of ATP, Ca

Indexed as

ApoptosisConformational diseaseERER stressMisfolded proteinsOxidative stressPDIRedoxUPR

Identifiers

PMID25309899
PMCPMC4192724
OpenAlexW2081379703

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.