Evidence map›Paper›PMID 25309682›Full record

ArticleTechnology and innovation2014

QUANTITATIVE MORPHOLOGICAL AND MOLECULAR PATHOLOGY OF THE HUMAN THYMUS CORRELATE WITH INFANT CAUSE OF DEATH.

Mark C Lloyd, Nancy Burke, Fatemeh Kalantarpour, Melissa I Niesen, Aaron Hall, Keith Pennypacker, Bruce Citron, Chaim G Pick, Vernard Adams, Mahasweta Das and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Technology and innovation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 93% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Mark C LloydAnalytic Microscopy Core, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Nancy BurkeAnalytic Microscopy Core, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Fatemeh KalantarpourDepartment of Oncological Sciences, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Melissa I NiesenDepartment of Molecular Medicine, University of South Florida, Tampa, FL, USA.
Aaron HallDepartment of Molecular Pharmacology and Physiology, University of South Florida, Tampa, FL, USA.
Keith PennypackerDepartment of Molecular Pharmacology and Physiology, University of South Florida, Tampa, FL, USA.
Bruce CitronDepartment of Molecular Medicine, University of South Florida, Tampa, FL, USA ; Laboratory of Molecular Biology, Bay Pines VA Healthcare System, Bay Pines, FL, USA.
Chaim G PickDepartment of Anatomy and Anthropology, Tel Aviv University, Tel Aviv, Israel.
Vernard AdamsMedical Examiner Department, Hillsborough County Government, Tampa, FL, USA ; Department of Pathology and Cell Biology, University of South Florida, Tampa, FL, USA.
Mahasweta DasDepartment of Internal Medicine, University of South Florida, Tampa, FL, USA.
Shyam MohapatraDepartment of Internal Medicine, University of South Florida, Tampa, FL, USA.
Hernani CualingDepartment of Pathology and Cell Biology, University of South Florida, Tampa, FL, USA ; IHCFLOW, Inc., Lutz, FL, USA.
George BlanckDepartment of Oncological Sciences, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA ; Department of Molecular Medicine, University of South Florida, Tampa, FL, USA.
University of South Florida · USMoffitt Cancer Center · USTel Aviv University · IL

Funding

TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI KENNETH Lynn WRIGHT · 1998 to 2026
$93.5M
Anti-oxidant Promoting Cytokine LIF Enhances Neural Cell Survival During IschemiaR21NS078517 · NINDS · UNIVERSITY OF SOUTH FLORIDA · PI PENNYPACKER, KEITH R · 2012 to 2013
$403k
NCI NIH HHS P30 CA076292NINDS NIH HHS R21 NS078517
6 · The paper itself

Abstract

The objective of this study was to investigate and quantify the morphological and molecular changes in the thymus for common causes of human infant death. Thymic architecture and molecular changes apparent in human infant head trauma victims were assessed by microscopy and quantified by image analysis of digital whole slide images. Thymuses from victims of SIDS and suffocated infants displaying normal thymus architecture were used for comparison. Molecular expression of proliferation and serotonin receptor and transporter protein markers was evaluated. Duplicate morphological and molecular studies of rodent thymuses were completed with both mouse and rat models. Quantification of novel parameters of digital images of thymuses from human infants suffering mortal head trauma revealed a disruption of the corticomedullary organization of the thymus, particularly involving dissolution of the corticomedullary border. A similar result was obtained for related mouse and rat models. The human thymuses from head trauma cases also displayed a higher percentage of Ki-67-positive thymocytes. Finally, we determined that thymus expression of the human serotonin receptor, and the serotonin transporter, occur almost exclusively in the thymic medulla. Head trauma leads to a disruption of the thymic, corticomedullary border, and molecular expression patterns in a robust and quantifiable manner.

Indexed as

Head traumaInfantQuantitative pathologySerotoninSerotonin receptorT-cellsThymus gland

Identifiers

PMID25309682
PMCPMC4192662
OpenAlexW1989421216

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.