Evidence map›Paper›PMID 25309643›Full record

ArticleStatistics surveys2013

Analyzing complex functional brain networks: Fusing statistics and network science to understand the brain

Sean L Simpson, F DuBois Bowman, Paul J Laurienti

Open access · diamondAbstract read
In one paragraph

Article in Statistics surveys, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 130 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Statistical Brain Network Analysis.Annual review of statistics and its application · 2024
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. R-Mixup: Riemannian Mixup for Biological Networks.KDD : proceedings. International Conference on Knowledge Discovery & Data Mining · 2023
    Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. A mixed-modeling framework for whole-brain dynamic network analysis.Network neuroscience (Cambridge, Mass.) · 2022
    Article
  16. Review
  17. A regression framework for brain network distance metrics.Network neuroscience (Cambridge, Mass.) · 2022
    Article
  18. Article
  19. Article
  20. Mixed Modeling Frameworks for Analyzing Whole-Brain Network Data.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Sean L SimpsonDepartment of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC.
F DuBois BowmanDepartment of Biostatistics and Bioinformatics, The Rollins School of Public Health, Emory University, Atlanta, GA.
Paul J LaurientiDepartment of Radiology, Wake Forest School of Medicine, Winston-Salem, NC.
Wake Forest University · US

Funding

Wake Forest Claude D. Pepper OAIC - RenewalP30AG021332 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Jamie Nicole Justice · 2002 to 2026
$36.4M
Analytic Methods for Determining Multimodal Biomarkers for Parkinson's DiseaseU18NS082143 · NINDS · EMORY UNIVERSITY · PI BOWMAN, F. DUBOIS · 2012 to 2014
$882k
Statistical Methods for Whole-Brain Connectivety NetworksK25EB012236 · NIBIB · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI SIMPSON, SEAN L · 2012 to 2016
$796k
NIA NIH HHS P30 AG021332NIBIB NIH HHS K25 EB012236NINDS NIH HHS U18 NS082143
6 · The paper itself

Abstract

Complex functional brain network analyses have exploded over the last decade, gaining traction due to their profound clinical implications. The application of network science (an interdisciplinary offshoot of graph theory) has facilitated these analyses and enabled examining the brain as an integrated system that produces complex behaviors. While the field of statistics has been integral in advancing activation analyses and some connectivity analyses in functional neuroimaging research, it has yet to play a commensurate role in complex network analyses. Fusing novel statistical methods with network-based functional neuroimage analysis will engender powerful analytical tools that will aid in our understanding of normal brain function as well as alterations due to various brain disorders. Here we survey widely used statistical and network science tools for analyzing fMRI network data and discuss the challenges faced in filling some of the remaining methodological gaps. When applied and interpreted correctly, the fusion of network scientific and statistical methods has a chance to revolutionize the understanding of brain function.

Indexed as

connectivityfMRIGraph theorynetwork modelneuroimagingsmall-world

Identifiers

PMID25309643
PMCPMC4189131
OpenAlexW2118446773

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.