Evidence map›Paper›PMID 25309621›Full record

ArticleNature photonics2014

High-throughput optical screening of cellular mechanotransduction.

Jonathan L Compton, Justin C Luo, Huan Ma, Elliot Botvinick, Vasan Venugopalan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature photonics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Laser-Induced Shockwave (LIS) to Study Neuronal CaFrontiers in bioengineering and biotechnology · 2021
    Article
  6. Article
  7. Dynamics and mechanisms of intracellular calcium waves elicited by tandem bubble-induced jetting flow.Proceedings of the National Academy of Sciences of the United States of America · 2018
    Article
  8. Review
  9. Article
  10. Article
  11. Article
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  14. Review
  15. Article
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  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jonathan L ComptonDepartment of Chemical Engineering and Materials Science, University of California, Irvine ; Laser Microbeam and Medical Program, Beckman Laser Institute, University of California, Irvine.
Justin C LuoLaser Microbeam and Medical Program, Beckman Laser Institute, University of California, Irvine ; Department of Biomedical Engineering, University of California, Irvine.
Huan MaDepartment of Chemical Engineering and Materials Science, University of California, Irvine ; Laser Microbeam and Medical Program, Beckman Laser Institute, University of California, Irvine.
Elliot BotvinickLaser Microbeam and Medical Program, Beckman Laser Institute, University of California, Irvine ; Department of Biomedical Engineering, University of California, Irvine ; Edwards Lifesciences Center for Advanced Cardiovascular Technology, University of California, Irvine.
Vasan VenugopalanDepartment of Chemical Engineering and Materials Science, University of California, Irvine ; Laser Microbeam and Medical Program, Beckman Laser Institute, University of California, Irvine ; Department of Biomedical Engineering, University of California, Irvine.

Funding

WOUND MIGRATION FORCE MONITORINGP41RR001192 · NCRR · UNIVERSITY OF CALIFORNIA-IRVINE · PI LYUBOVITSKY, JULIA · 1985 to 2011
$14.2M
Virtual Photonocs TechnologiesP41EB015890 · NIBIB · UNIVERSITY OF CALIFORNIA-IRVINE · PI DURKIN, ANTHONY J · 2012 to 2017
$7.0M
NCRR NIH HHS P41 RR001192NIBIB NIH HHS P41 EB015890
6 · The paper itself

Abstract

We introduce an optical platform for rapid, high-throughput screening of exogenous molecules that affect cellular mechanotransduction. Our method initiates mechanotransduction in adherent cells using single laser-microbeam generated micro-cavitation bubbles (μCBs) without requiring flow chambers or microfluidics. These μCBs expose adherent cells to a microTsunami, a transient microscale burst of hydrodynamic shear stress, which stimulates cells over areas approaching 1mm

Identifiers

PMID25309621
PMCPMC4189826

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.