ArticleFrontiers in neurology2014
Altered FMRI connectivity dynamics in temporal lobe epilepsy might explain seizure semiology.
Article in Frontiers in neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04799795 (Objective EEG Bed Side Assessment of Impaired Conscious Awareness in Epilepsy), which is not on this map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Objective EEG Bed Side Assessment of Impaired Conscious Awareness in Epilepsy
Who cites it
33 citing papers in PubMed, 63 citations in OpenAlex.
- Commonalities and distinctions of static and dynamic functional connectivity density between left and right temporal lobe epilepsy.Scientific reports · 2026Article
- Graph Attention Networks for Detecting Epilepsy From EEG Signals Using Accessible Hardware in Low-Resource Settings.IEEE open journal of engineering in medicine and biology · 2026Article
- The potential of laminar functional MRI in refining the understanding of epilepsy in humans.Brain : a journal of neurology · 2025Review
- Motor and default mode network states of rest in frontal lobe epilepsy.Neuroimage. Reports · 2025Article
- Aberrant functional connectivity of amygdala subregions in temporal lobe epilepsy with ictal panic.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Aberrant white matter and subcortical gray matter functional network connectivity associated with static and dynamic characteristics in subjects with temporal lobe epilepsy.Frontiers in neuroscience · 2025Article
- Brain activation and connection across resting and motor-task states in patients with generalized tonic-clonic seizures.CNS neuroscience & therapeutics · 2024Article
- Metabolic connectivity as a predictor of surgical outcome in mesial temporal lobe epilepsy.Epilepsia open · 2024Article
- Camera-based Prospective Motion Correction in Paediatric Epilepsy Patients Enables EEG-fMRI Localization Even in High-motion States.Brain topography · 2023Article
- Review
- Hippocampal atrophy and quantitative EEG markers in mild cognitive impairment in temporal lobe epilepsy versus extra-temporal lobe epilepsy.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- More than just statics: Static and temporal dynamic changes in intrinsic brain activity in unilateral temporal lobe epilepsy.Frontiers in human neuroscience · 2022Article
- The neural foundation of associative memory: a dynamic functional connectivity study for right-handed young adults.Experimental brain research · 2021Article
- Quantitative assessment of structural and functional changes in temporal lobe epilepsy with hippocampal sclerosis.Quantitative imaging in medicine and surgery · 2021Article
- Decreased Intrinsic Neural Timescales in Mesial Temporal Lobe Epilepsy.Frontiers in human neuroscience · 2021Article
- Dynamical Mechanisms of Interictal Resting-State Functional Connectivity in Epilepsy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- A Novel Microwave Treatment for Sleep Disorders and Classification of Sleep Stages Using Multi-Scale Entropy.Entropy (Basel, Switzerland) · 2020Article
- Temporal lobe epilepsy alters spatio-temporal dynamics of the hippocampal functional network.NeuroImage. Clinical · 2020Article
- Pushing the Limits of EEG: Estimation of Large-Scale Functional Brain Networks and Their Dynamics Validated by Simultaneous fMRI.Frontiers in neuroscience · 2020Article
- Modulation of epileptic networks by transient interictal epileptic activity: A dynamic approach to simultaneous EEG-fMRI.NeuroImage. Clinical · 2020Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
Temporal lobe epilepsy (TLE) can be conceptualized as a network disease. The network can be characterized by inter-regional functional connectivity, i.e., blood oxygen level-dependent (BOLD) signal correlations between any two regions. However, functional connectivity is not constant over time, thus computing correlation at a given time and then at some later time could give different results (non-stationarity). We hypothesized (1) that non-stationarities can be induced by epilepsy (e.g., interictal epileptic activity) increasing local signal variance and that (2) these transient events contribute to fluctuations in connectivity leading to pathological functioning, i.e., TLE semiology. We analyzed fMRI data from 27 patients with TLE and 22 healthy controls focusing on EEG-confirmed wake epochs only to protect against sleep-induced connectivity changes. Testing hypothesis (1), we identified brain regions where the BOLD signal variance was significantly greater in TLE than in controls: the temporal pole - including the hippocampus. Taking the latter as the seed region and testing hypothesis (2), we calculated the time-varying inter-regional correlation values (dynamic functional connectivity) to other brain regions and found greater connectivity variance in the TLE than the control group mainly in the precuneus, the supplementary and sensorimotor, and the frontal cortices. We conclude that the highest BOLD signal variance in the hippocampi is highly suggestive of a specific epilepsy-related effect. The altered connectivity dynamics in TLE patients might help to explain the hallmark semiological features of dyscognitive seizures including impaired consciousness (precuneus, frontal cortex), sensory disturbance, and motor automatisms (sensorimotor cortices, supplementary motor cortex). Accounting for the non-stationarity and state-dependence of functional connectivity are a prerequisite in the search for potential connectivity-derived biomarkers in TLE.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.