ReviewFrontiers in physiology2014
Skeletal muscle myofilament adaptations to aging, disease, and disuse and their effects on whole muscle performance in older adult humans.
Review in Frontiers in physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01190046 (Muscle Disuse and Contractile Dysfunction in the Elderly), which is not on this map. Cited by 47 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Muscle Disuse and Contractile Dysfunction in the Elderly
Who cites it
47 citing papers in PubMed, 78 citations in OpenAlex.
- Sustaining neuromuscular activation after total knee arthroplasty preserves skeletal muscle fiber size, contractility, and innervation in older adults.Experimental gerontology · 2025Trial
- Triceps surae muscle-subtendon interaction differs between young and older adults.Connective tissue research · 2020Trial
- Association between TMG-derived contractile muscle parameters and MRI-based muscle structure in sarcopenia.BMC musculoskeletal disorders · 2026Article
- A Comparison of the Force-Velocity Relationship of Bonobo and Human Muscle Fibers.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2025Article
- Impact of Physical Activity Level on Whole-Body and Muscle-Cell Function in Older Adults.Annals of geriatric medicine and research · 2025Article
- Mass Spectrometry-Based Multiomics Identifies Metabolic Signatures of Sarcopenia in Rhesus Monkey Skeletal Muscle.Journal of proteome research · 2024Article
- The inorganic NItrate and eXercise performance in Heart Failure (iNIX-HF) phase II clinical trial: Rationale and study design.Contemporary clinical trials communications · 2023Article
- Quadriceps Strength, Postural Stability, and Pain Mediation in Bilateral Knee Osteoarthritis: A Comparative Analysis with Healthy Controls.Diagnostics (Basel, Switzerland) · 2023Article
- Bile Acids Alter the Autophagy and Mitogenesis in Skeletal Muscle Cells.Advances in experimental medicine and biology · 2023Article
- Reference Equation of a New Incremental Step Test to Assess Exercise Capacity in the Portuguese Adult Population.Journal of clinical medicine · 2022Article
- Macrophage immunomodulation accelerates skeletal muscle functional recovery in aged mice following disuse atrophy.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- Potential mechanisms involved in regulating muscle protein turnover after acute exercise: A brief review.Frontiers in physiology · 2022Review
- Exercise Physiology Impairments of Patients With Amyotrophic Lateral Sclerosis: Cardiopulmonary Exercise Testing Findings.Frontiers in physiology · 2022Article
- Article
- Age-related increase in muscle stiffness is muscle length dependent and associated with muscle force in senior females.BMC musculoskeletal disorders · 2021Article
- The effects of triceps surae muscle stimulation on localized Achilles subtendon tissue displacements.The Journal of experimental biology · 2021Article
- Normative Values for the Unsupported Upper Limb Exercise Test and 6-Minute Pegboard and Ring Test in Healthy Canadian Adults.Physiotherapy Canada. Physiotherapie Canada · 2020Article
- Clinician's Commentary on Lima et al.Physiotherapy Canada. Physiotherapie Canada · 2020Article
- Remodeling the Skeletal Muscle Extracellular Matrix in Older Age-Effects of Acute Exercise Stimuli on Gene Expression.International journal of molecular sciences · 2020Article
- CaAmerican journal of physiology. Cell physiology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Skeletal muscle contractile function declines with aging, disease, and disuse. In vivo muscle contractile function depends on a variety of factors, but force, contractile velocity and power generating capacity ultimately derive from the summed contribution of single muscle fibers. The contractile performance of these fibers are, in turn, dependent upon the isoform and function of myofilament proteins they express, with myosin protein expression and its mechanical and kinetic characteristics playing a predominant role. Alterations in myofilament protein biology, therefore, may contribute to the development of functional limitations and disability in these conditions. Recent studies suggest that these conditions are associated with altered single fiber performance due to decreased expression of myofilament proteins and/or changes in myosin-actin cross-bridge interactions. Furthermore, cellular and myofilament-level adaptations are related to diminished whole muscle and whole body performance. Notably, the effect of these various conditions on myofilament and single fiber function tends to be larger in older women compared to older men, which may partially contribute to their higher rates of disability. To maintain functionality and provide the most appropriate and effective countermeasures to aging, disease, and disuse in both sexes, a more thorough understanding is needed of the contribution of myofilament adaptations to functional disability in older men and women and their contribution to tissue level function and mobility impairment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.