ReviewFrontiers in physiology2014
Capturing structure and function in an embryonic heart with biophotonic tools.
Review in Frontiers in physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed.
- Image scanning microscopy based on multifocal metalens for sub-diffraction-limited imaging of brain organoids.Light, science & applications · 2025Article
- Accelerating photoacoustic microscopy by reconstructing undersampled images using diffusion models.Scientific reports · 2024Article
- Noninvasive Tracking of Embryonic Cardiac Dynamics and Development with Volumetric Optoacoustic Spectroscopy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Segmentation of beating embryonic heart structures from 4-D OCT images using deep learning.Biomedical optics express · 2023Article
- A method for investigating spatiotemporal growth patterns at cell and tissue levels during C-looping in the embryonic chick heart.iScience · 2022Article
- Folic acid prevents functional and structural heart defects induced by prenatal ethanol exposure.American journal of physiology. Heart and circulatory physiology · 2021Article
- Glutathione Protects the Developing Heart from Defects and Global DNA Hypomethylation Induced by Prenatal Alcohol Exposure.Alcoholism, clinical and experimental research · 2021Article
- Embryonic Mouse Cardiodynamic OCT Imaging.Journal of cardiovascular development and disease · 2020Review
- Validating the Paradigm That Biomechanical Forces Regulate Embryonic Cardiovascular Morphogenesis and Are Fundamental in the Etiology of Congenital Heart Disease.Journal of cardiovascular development and disease · 2020Review
- Label-free optical imaging in developmental biology [Invited].Biomedical optics express · 2020Review
- Speckle variance optical coherence tomography of blood flow in the beating mouse embryonic heart.Journal of biophotonics · 2017Article
- Dynamic imaging and quantitative analysis of cranial neural tube closure in the mouse embryo using optical coherence tomography.Biomedical optics express · 2017Article
- Cardiac neural crest ablation results in early endocardial cushion and hemodynamic flow abnormalities.American journal of physiology. Heart and circulatory physiology · 2016Article
- Ultrahigh-speed, phase-sensitive full-field interferometric confocal microscopy for quantitative microscale physiology.Biomedical optics express · 2016Article
- Four-dimensional live imaging of hemodynamics in mammalian embryonic heart with Doppler optical coherence tomography.Journal of biophotonics · 2016Article
- Probing the Electrophysiology of the Developing Heart.Journal of cardiovascular development and disease · 2016Review
- Direct four-dimensional structural and functional imaging of cardiovascular dynamics in mouse embryos with 1.5 MHz optical coherence tomography.Optics letters · 2015Article
- Editorial: Mechanotransduction and development of cardiovascular form and function.Frontiers in physiology · 2015Article
- Optical Coherence Tomography for Brain Imaging and Developmental Biology.IEEE journal of selected topics in quantum electronics : a publication of the IEEE Lasers and Electro-optics SocietyArticle
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Disturbed cardiac function at an early stage of development has been shown to correlate with cellular/molecular, structural as well as functional cardiac anomalies at later stages culminating in the congenital heart defects (CHDs) that present at birth. While our knowledge of cellular and molecular steps in cardiac development is growing rapidly, our understanding of the role of cardiovascular function in the embryo is still in an early phase. One reason for the scanty information in this area is that the tools to study early cardiac function are limited. Recently developed and adapted biophotonic tools may overcome some of the challenges of studying the tiny fragile beating heart. In this chapter, we describe and discuss our experience in developing and implementing biophotonic tools to study the role of function in heart development with emphasis on optical coherence tomography (OCT). OCT can be used for detailed structural and functional studies of the tubular and looping embryo heart under physiological conditions. The same heart can be rapidly and quantitatively phenotyped at early and again at later stages using OCT. When combined with other tools such as optical mapping (OM) and optical pacing (OP), OCT has the potential to reveal in spatial and temporal detail the biophysical changes that can impact mechanotransduction pathways. This information may provide better explanations for the etiology of the CHDs when interwoven with our understanding of morphogenesis and the molecular pathways that have been described to be involved. Future directions for advances in the creation and use of biophotonic tools are discussed.
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Registered trials
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