ArticleFrontiers in physiology2014
Cerebral hemodynamics during graded Valsalva maneuvers.
Article in Frontiers in physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 46 citations in OpenAlex.
- Comparative Effects of Abdominal Bracing and Valsalva Maneuver on Cerebral and Peripheral Hemodynamics in Healthy Adults: A Randomized Crossover Study.Medicina (Kaunas, Lithuania) · 2025Trial
- Resistance exercise with combined Valsalva manoeuvre acutely increases carotid-femoral pulse wave velocity in healthy untrained individuals.European journal of applied physiology · 2026Article
- Concomitant Dysregulation of Cerebral Vasoreactivity and Arterial Blood Pressure Is Closely Related in Patients with Carotid Stenosis.Life (Basel, Switzerland) · 2026Article
- Trigger Factors of Primary Cerebral Hemorrhage Onset: A Case-Crossover Study.Health science reports · 2025Article
- Impact of mode of delivery on maternal and fetal outcomes in pregnant patients with heart failure or pulmonary hypertension.American journal of preventive cardiology · 2025Article
- Dizziness and spatial disorientation in patients with transient global amnesia: clinical and vestibular correlates.Journal of neurology · 2025Article
- A Novel Approach to Non-Invasive Intracranial Pressure Wave Monitoring: A Pilot Healthy Brain Study.Sensors (Basel, Switzerland) · 2025Article
- Effects of resistance exercise intensity on cerebral blood flow and cerebrovascular reactivity in healthy young males: A pilot study.Physiological reports · 2025Article
- Diffuse optical tomography system for acute traumatic brain injury in the intensive care unit: a prospective study on healthy volunteers.Journal of biomedical optics · 2025Article
- Autoregulatory dysfunction in adult Moyamoya disease with cerebral hyperperfusion syndrome after bypass surgery.Scientific reports · 2024Article
- Lower dynamic cerebral autoregulation following acute bout of low-volume high-intensity interval exercise in chronic stroke compared to healthy adults.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- The Impact of Valsalva Manoeuvres and Exercise on Intracranial Pressure and Cerebrovascular Dynamics in Idiopathic Intracranial Hypertension.Neuro-ophthalmology (Aeolus Press) · 2024Article
- Quantification of dynamic cerebral autoregulation: welcome to the jungle!Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2023Review
- Increased brain microvascular hemoglobin concentrations in children with cerebral malaria.Science translational medicine · 2023Article
- Fast time-domain diffuse correlation spectroscopy with superconducting nanowire single-photon detector: system validation and in vivo results.Scientific reports · 2023Article
- Transfer function analysis of dynamic cerebral autoregulation: A CARNet white paper 2022 update.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Review
- Cerebral autoregulation across the menstrual cycle in eumenorrheic women.Physiological reports · 2022Article
- Cerebrovascular response to an acute bout of low-volume high-intensity interval exercise and recovery in young healthy adults.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- The Acute Cardiorespiratory and Cerebrovascular Response to Resistance Exercise.Sports medicine - open · 2021Review
- Cardiovascular fingolimod effects on rapid baroreceptor unloading are counterbalanced by baroreflex resetting.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Valsalva maneuver (VM) produces large and abrupt changes in mean arterial pressure (MAP) that challenge cerebral blood flow and oxygenation. We examined the effect of VM intensity on middle cerebral artery blood velocity (MCAv) and cortical oxygenation responses during (phases I-III) and following (phase IV) a VM. Healthy participants (n = 20 mean ± SD: 27 ± 7 years) completed 30 and 90% of their maximal VM mouth pressure for 10 s (order randomized) whilst standing. Beat-to-beat MCAv, cerebral oxygenation (NIRS) and MAP across the different phases of the VM are reported as the difference from standing baseline. There were significant interaction (phase (*) intensity) effects for MCAv, total oxygenation index (TOI) and MAP (all P < 0.01). MCAv decreased during phases II and III (P < 0.01), with the greatest decrease during phase III (-5 ± 8 and -19 ± 15 cm·s(-1) for 30 and 90% VM, respectively). This pattern was also evident in TOI (phase III: -1 ± 1 and -5 ± 4%, both P < 0.05). Phase IV increased MCAv (22 ± 15 and 34 ± 23 cm·s(-1)), MAP (15 ± 14 and 24 ± 17 mm Hg) and TOI (5 ± 6 and 7 ± 5%) relative to baseline (all P < 0.05). Cerebral autoregulation, indexed, as the %MCAv/%MAP ratio, showed a phase effect only (P < 0.001), with the least regulation during phase IV (2.4 ± 3.0 and 3.2 ± 2.9). These data illustrate that an intense VM profoundly affects cerebral hemodynamics, with a reactive hyperemia occurring during phase IV following modest ischemia during phases II and III.
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