ReviewFrontiers in physiology2014
Role of sympathetic nerve activity in the process of fainting.
Review in Frontiers in physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Forensic pathological analysis of sudden cardiac death in 10 cases with congenital coronary ostial stenosis: a technical report.Forensic science, medicine, and pathology · 2026Pooled it
- Effects of plantar stimulation on cardiovascular response to orthostatism.European journal of applied physiology · 2016Trial
- Difference in clinical characteristics between functional syncope and vasovagal syncope in children.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Phenotyping Dysautonomia in Unexplained Syncope: Diagnostic Yield and Therapeutic Implications in a Moroccan Cohort.Cureus · 2026Article
- Association of Vitamin B12 and Folate Deficiency with Vasovagal Syncope: A Case-Control Study.Research in heart yield and translational medicine · 2026Article
- Effects of urination process on heart rate variability.International urology and nephrology · 2025Article
- Advances in diagnosis, management, and long-term outcomes of pediatric vasovagal syncope: a comprehensive review.Frontiers in cardiovascular medicine · 2025Review
- Predictive value of Tpeak-Tend interval of supine and orthostatic electrocardiogram in the diagnosis between psychogenic pseudosyncope and vasovagal syncope in children.Scientific reports · 2024Article
- Psychopathological Correlates and Psychosocial Functioning in Children and Adolescents with Syncope: A Systematic Review.Clinical neuropsychiatry · 2024Review
- Predicting therapeutic efficacy of oral rehydration salts in children with vasovagal syncope.Frontiers in pediatrics · 2023Article
- Markers for predicting the efficacy of beta-blockers in vasovagal syncope management in children: A mini-review.Frontiers in cardiovascular medicine · 2023Review
- Safety, Pharmacokinetics/Pharmacodynamics, and Absolute Bioavailability of Dexmedetomidine Hydrochloride Nasal Spray in Healthy Subjects: A Randomized, Parallel, Escalating Dose Study.Frontiers in pharmacology · 2022Article
- Neurogenic Hypotension and Bradycardia Modulated by Electroacupuncture in Hypothalamic Paraventricular Nucleus.Frontiers in neuroscience · 2022Article
- Syncope associated with supraventricular tachycardia: Diagnostic role of implantable loop recorders.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2021Article
- Postural Changes on Heart Rate Variability among Older Population: A Preliminary Study.Current gerontology and geriatrics research · 2021Article
- Skin sympathetic nerve activity as a biomarker for syncopal episodes during a tilt table test.Heart rhythm · 2020Article
- Timing of Circulatory and Neurological Events in Syncope.Frontiers in cardiovascular medicine · 2020Review
- Use of stellate ganglion block for treatment of recurrent syncope followed by chest pain.Yeungnam University journal of medicine · 2018Article
- Modulation of Neurally Mediated Vasodepression and Bradycardia by Electroacupuncture through Opioids in Nucleus Tractus Solitarius.Scientific reports · 2018Article
- Exercise-Induced Modulation of Baroreflex Control of Sympathetic Nerve Activity.Frontiers in neuroscience · 2018Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Syncope is defined as a transient loss of consciousness and postural tone, characterized by rapid onset, short duration, and spontaneous recovery, and the process of syncope progression is here described with two types of sympathetic change. Simultaneous recordings of microneurographically-recorded muscle sympathetic nerve activity (MSNA) and continuous and noninvasive blood pressure measurement has disclosed what is going on during the course of syncope progression. For vasovagal or neurally mediated syncope, three stages are identified in the course of syncope onset, oscillation, imbalance, and catastrophe phases. Vasovagal syncope is characterized by sympathoexcitation, followed by vagal overcoming via the Bezold-Jarisch reflex. Orthostatic syncope is caused by response failure or a lack of sympathetic nerve activity to the orthostatic challenge, followed by fluid shift and subsequent low cerebral perfusion. Four causes are considered for the compensatory failure that triggers orthostatic syncope: hypovolemia, increased pooling in the lower body, failure to activate sympathetic activity, and failure of vasoconstriction against sympathetic vasoconstrictive stimulation. Many pathophysiological conditions have been described from the perspectives of (1) exaggerated sympathoexcitation and (2) failure to activate the sympathetic nerve. We conclude that the sympathetic nervous system can control cardiovascular function, and its failure results in syncope; however, responses of the system obtained by microneurographically-recorded MSNA would determine the pathophysiology of the onset and progression of syncope, explaining the treatment effect that could be achieved by the analysis of this mechanism.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.