ArticleFrontiers in aging neuroscience2014
Magnetization transfer ratio relates to cognitive impairment in normal elderly.
Article in Frontiers in aging neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Enlarged perivascular spaces and cognition: A meta-analysis of 5 population-based studies.Neurology · 2018Pooled it
- Cerebral white matter hyperintensities indicate severity and progression of coronary artery calcification.Scientific reports · 2024Article
- Fractal Dimension Studies of the Brain Shape in Aging and Neurodegenerative Diseases.Advances in neurobiology · 2024Article
- Grey-matter structure in cortical and limbic regions correlates with general cognitive ability in old age.Aging brain · 2024Article
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- Advanced MRI in cerebral small vessel disease.International journal of stroke : official journal of the International Stroke Society · 2023Review
- Evidence of polygenic regulation of the physiological presence of neurofilament light chain in human serum.Frontiers in neurology · 2023Article
- Longitudinal assessment of magnetization transfer ratio, brain volume, and cognitive functions in diffuse axonal injury.Brain and behavior · 2022Article
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- Determining the OPTIMAL DTI analysis method for application in cerebral small vessel disease.NeuroImage. Clinical · 2022Article
- The MRi-Share database: brain imaging in a cross-sectional cohort of 1870 university students.Brain structure & function · 2021Article
- Incidental findings of typical iNPH imaging signs in asymptomatic subjects with subclinical cognitive decline.Fluids and barriers of the CNS · 2021Article
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- The Meta VCI Map consortium for meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping: Design and multicenter pilot study.Alzheimer's & dementia (Amsterdam, Netherlands) · 2019Article
- Data fusion detects consistent relations between non-lesional white matter myelin, executive function, and clinical characteristics in multiple sclerosis.NeuroImage. Clinical · 2019Article
- Pharmacological and Non-pharmacological Therapies of Cognitive Impairment in Multiple Sclerosis.Current neuropharmacology · 2018Review
- Gray matter heritability in family-based and population-based studies using voxel-based morphometry.Human brain mapping · 2017Article
- Lower Magnetization Transfer Ratio in the Forceps Minor Is Associated with Poorer Gait Velocity in Older Adults.AJNR. American journal of neuroradiology · 2017Article
- Association between changes in brain microstructure and cognition in older subjects at increased risk for vascular disease.BMC neurology · 2015Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Magnetization transfer imaging (MTI) can detect microstructural brain tissue changes and may be helpful in determining age-related cerebral damage. We investigated the association between the magnetization transfer ratio (MTR) in gray and white matter (WM) and cognitive functioning in 355 participants of the Austrian stroke prevention family study (ASPS-Fam) aged 38-86 years. MTR maps were generated for the neocortex, deep gray matter structures, WM hyperintensities, and normal appearing WM (NAWM). Adjusted mixed models determined whole brain and lobar cortical MTR to be directly and significantly related to performance on tests of memory, executive function, and motor skills. There existed an almost linear dose-effect relationship. MTR of deep gray matter structures and NAWM correlated to executive functioning. All associations were independent of demographics, vascular risk factors, focal brain lesions, and cortex volume. Further research is needed to understand the basis of this association at the tissue level, and to determine the role of MTR in predicting cognitive decline and dementia.
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