ArticleFrontiers in aging neuroscience2014
Decreased Default Mode Network connectivity correlates with age-associated structural and cognitive changes.
Article in Frontiers in aging neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 1 of them a synthesis that pooled it.
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Who cites it
77 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neuroimaging alterations in dementia with Lewy bodies and neuroimaging differences between dementia with Lewy bodies and Alzheimer's disease: An activation likelihood estimation meta-analysis.CNS neuroscience & therapeutics · 2022Pooled it
- Multimodal fusion of structural and functional brain imaging in depression using linked independent component analysis.Human brain mapping · 2020Trial
- Changes in Neural Connectivity and Memory Following a Yoga Intervention for Older Adults: A Pilot Study.Journal of Alzheimer's disease : JAD · 2016Trial
- Disrupted white matter functional connectivity in post-stroke cognitive impairment: Insights from resting-state fMRI.Brain imaging and behavior · 2026Article
- Age-Related Low Frequency Amplitude Differences in Resting-State Blood Oxygenation Level-Dependent Signal in the Cerebellum.Human brain mapping · 2026Article
- The CAIDE dementia risk score indicates elevated cognitive risk in late adulthood: a structural and functional neuroimaging study.GeroScience · 2026Article
- Modelling cognitive outcomes in the UK Biobank: Education, noradrenaline and frontoparietal networks.PloS one · 2026Article
- Move to Remember: The Role of Physical Activity and Exercise in Preserving and Enhancing Cognitive Function in Aging-A Narrative Review.Geriatrics (Basel, Switzerland) · 2025Review
- Repeated, sustained inflammation affects hippocampal dependent learning and neuroinflammation across age and sex.Behavioural brain research · 2025Article
- Aberrant functional connectivity between the retrosplenial cortex and hippocampal subregions in amnestic mild cognitive impairment and Alzheimer's disease.Brain communications · 2025Article
- Advanced age and neurological recovery in elderly patients with out-of-hospital cardiac arrest treated with targeted temperature management: a nationwide population‑based registry study 2016-2020.Internal and emergency medicine · 2025Observational
- Intrinsic functional connectivity brain networks mediate effect of age on sociability.PloS one · 2025Article
- Advances in the fMRI analysis of the default mode network: a review.Brain structure & function · 2024Review
- Towards a neurodevelopmental cognitive perspective of temporal processing.Communications biology · 2024Review
- Impact of sex and reproductive status on the default mode network in early midlife: implications for aging of memory circuitry and function.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Leveraging the Metaverse for Enhanced Longevity as a Component of Health 4.0.Mayo Clinic proceedings. Digital health · 2024Review
- Brain topology underlying executive functions across the lifespan: focus on the default mode network.Frontiers in psychology · 2024Article
- SuperAging functional connectomics from resting-state functional MRI.Brain communications · 2024Article
- Interactions between the aging brain and motor task complexity across the lifespan: balancing brain activity resource demand and supply.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Source connectivity patterns in the default mode network differ between elderly golf-novices and non-golfers.Scientific reports · 2023Article
17 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors.
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Abstract
Ageing entails cognitive and motor decline as well as brain changes such as loss of gray (GM) and white matter (WM) integrity, neurovascular and functional connectivity alterations. Regarding connectivity, reduced resting-state fMRI connectivity between anterior and posterior nodes of the Default Mode Network (DMN) relates to cognitive function and has been postulated to be a hallmark of ageing. However, the relationship between age-related connectivity changes and other neuroimaging-based measures in ageing is fragmentarily investigated. In a sample of 116 healthy elders we aimed to study the relationship between antero-posterior DMN connectivity and measures of WM integrity, GM integrity and cerebral blood flow (CBF), assessed with an arterial spin labeling sequence. First, we replicated previous findings demonstrating DMN connectivity decreases in ageing and an association between antero-posterior DMN connectivity and memory scores. The results showed that the functional connectivity between posterior midline structures and the medial prefrontal cortex was related to measures of WM and GM integrity but not to CBF. Gray and WM correlates of anterio-posterior DMN connectivity included, but were not limited to, DMN areas and cingulum bundle. These results resembled patterns of age-related vulnerability which was studied by comparing the correlates of antero-posterior DMN with age-effect maps. These age-effect maps were obtained after performing an independent analysis with a second sample including both young and old subjects. We argue that antero-posterior connectivity might be a sensitive measure of brain ageing over the brain. By using a comprehensive approach, the results provide valuable knowledge that may shed further light on DMN connectivity dysfunctions in ageing.
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