ReviewFrontiers in aging neuroscience2014
Mitochondrial involvement and impact in aging skeletal muscle.
Review in Frontiers in aging neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.
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Who cites it
85 citing papers in PubMed, 150 citations in OpenAlex.
- The exerkine apelin reverses age-associated sarcopenia.Nature medicine · 2018Trial
- Effect of dietary n-3 PUFA supplementation on the muscle transcriptome in older adults.Physiological reports · 2016Trial
- Scratching beneath the surface: Quantification of muscle architecture and myosin heavy chain content in the forelimbs of black-tailed prairie dogs (Cynomys, Rodentia).Journal of anatomy · 2026Article
- The Impact of Ageing on Skeletal Muscle: Roles of Mitochondrial Dysregulation, Systemic Communication, and Exercise.Journal of cellular physiology · 2026Review
- Exercise training to preserve vitality capacity in ageing.Experimental physiology · 2026Review
- The MICOS Complex Regulates Mitochondrial Structure and Oxidative Stress During Age-Dependent Structural Deficits in the Kidney.Aging cell · 2026Article
- The MICOS Complex Regulates Mitochondrial Structure and Oxidative Stress During Age-Dependent Structural Deficits in the Kidney.bioRxiv : the preprint server for biology · 2026Article
- Effect of Denervation on Skeletal Muscle Mitochondria in Heterozygous mtDNA Mutator Mice.FASEB bioAdvances · 2026Article
- Article
- Construction and verification of a nomogram to estimate middle-aged and older individuals' susceptibility to sarcopenia.BMC musculoskeletal disorders · 2025Article
- Resilience of the mitochondrial reticulum in aging.American journal of physiology. Endocrinology and metabolism · 2025Article
- A multimodal exercise countermeasure prevents the negative impact of head-down tilt bed rest on muscle volume and mitochondrial health in older adults.The Journal of physiology · 2025Article
- The Impact of Protein and Amino Acid Supplementation on Muscular Strength and Endurance in Recreational Gym-Goers During 8-Week Resistance Training.Sports (Basel, Switzerland) · 2025Article
- Impact of physical activity on physical function, mitochondrial energetics, ROS production, and CaCell reports. Medicine · 2025Article
- Mitochondrial dysfunction in age-related sarcopenia: mechanistic insights, diagnostic advances, and therapeutic prospects.Frontiers in cell and developmental biology · 2025Review
- The legacy of Bruce Ames and mitochondrial DNA mutagenicity: integrating oxidative stress, aging, and modern perspectives.Frontiers in molecular biosciences · 2025Article
- Protein Acetylation and NAD+ Homeostasis in Aging Muscle.Advances in experimental medicine and biology · 2025Review
- Yoga Practice as a Potential Sarcopenia Prevention Strategy in Indonesian Older Adults: A Cross-Sectional Study.Open access journal of sports medicine · 2025Article
- Mechanisms of the NADFrontiers in cell and developmental biology · 2024Review
- How does exercise affect energy metabolism? AnHeliyon · 2023Article
25 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Atrophy is a defining feature of aging skeletal muscle that contributes to progressive weakness and an increased risk of mobility impairment, falls, and physical frailty in very advanced age. Amongst the most frequently implicated mechanisms of aging muscle atrophy is mitochondrial dysfunction. Recent studies employing methods that are well-suited to interrogating intrinsic mitochondrial function find that mitochondrial respiration and reactive oxygen species emission changes are inconsistent between aging rat muscles undergoing atrophy and appear normal in human skeletal muscle from septuagenarian physically active subjects. On the other hand, a sensitization to permeability transition seems to be a general property of atrophying muscle with aging and this effect is even seen in atrophying muscle from physically active septuagenarian subjects. In addition to this intrinsic alteration in mitochondrial function, factors extrinsic to the mitochondria may also modulate mitochondrial function in aging muscle. In particular, recent evidence implicates oxidative stress in the aging milieu as a factor that depresses respiratory function in vivo (an effect that is not present ex vivo). Furthermore, in very advanced age, not only does muscle atrophy become more severe and clinically relevant in terms of its impact, but also there is evidence that this is driven by an accumulation of severely atrophied denervated myofibers. As denervation can itself modulate mitochondrial function and recruit mitochondrial-mediated atrophy pathways, future investigations need to address the degree to which skeletal muscle mitochondrial alterations in very advanced age are a consequence of denervation, rather than a primary organelle defect, to refine our understanding of the relevance of mitochondria as a therapeutic target at this more advanced age.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.