ArticleFrontiers in human neuroscience2014
Cortical somatosensory reorganization in children with spastic cerebral palsy: a multimodal neuroimaging study.
Article in Frontiers in human neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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Who cites it
63 citing papers in PubMed, 110 citations in OpenAlex.
- Functional connectivity and upper limb function in patients after pediatric arterial ischemic stroke with contralateral corticospinal tract wiring.Scientific reports · 2021Trial
- Stochastic resonance stimulation improves balance in children with cerebral palsy: a case control study.Journal of neuroengineering and rehabilitation · 2018Trial
- Revolutionizing Pediatric Neurophysiology With Magnetoencephalography.Psychophysiology · 2026Review
- Functional and structural neuroplasticity of somatosensory system in hemiplegic cerebral palsy.Brain communications · 2026Article
- An exploratory pre-post study of an intensive somatosensory activity-based intervention on participation-related goals, motor performance and somatosensory function in children with unilateral cerebral palsy.Frontiers in pediatrics · 2026Article
- Anterior cingulate and its role in enhancing gait training outcomes in persons with cerebral palsy.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Dynamic Task-Related Changes in Electroencephalography Brain Connectivity During a Button-Press Task in Children with and Without Bilateral Cerebral Palsy.Brain connectivity · 2025Article
- Prevalence of Sensory Processing Deficits in Children with Spastic Cerebral Palsy - An Indian Caregiver's Perspective.Indian journal of pediatrics · 2024Article
- Tractography of sensorimotor pathways in dyskinetic cerebral palsy: Association with motor function.Annals of clinical and translational neurology · 2024Article
- Spatiotemporal dynamics of cortical somatosensory network in typically developing children.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Immediate application of low-intensity electrical noise reduced responses to visual perturbations during walking in individuals with cerebral palsy.Journal of neuroengineering and rehabilitation · 2024Article
- Reduced brainstem volume is associated with mobility impairments in youth with cerebral palsy.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia · 2023Article
- Investigation of the Relationship between Sensory-Processing Skills and Motor Functions in Children with Cerebral Palsy.Children (Basel, Switzerland) · 2023Article
- Limb-specific thalamocortical tracts are impaired differently in hemiplegic and diplegic subtypes of cerebral palsy.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Youth with Cerebral Palsy Display Abnormal Somatosensory Cortical Activity During a Haptic Exploration Task.Neuroscience · 2023Article
- Reduced Brainstem Volume is Associated with Mobility Impairments in Youth with Cerebral Palsy.Research square · 2023Article
- Aberrant age-related alterations in spontaneous cortical activity in participants with cerebral palsy.Frontiers in neurology · 2023Article
- A ValHeliyon · 2022Article
- Identification of proprioceptive thalamocortical tracts in children: comparison of fMRI, MEG, and manual seeding of probabilistic tractography.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Aberrant movement-related somatosensory cortical activity mediates the extent of the mobility impairments in persons with cerebral palsy.The Journal of physiology · 2022Article
3 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although cerebral palsy (CP) is among the most common causes of physical disability in early childhood, we know little about the functional and structural changes of this disorder in the developing brain. Here, we investigated with three different neuroimaging modalities [magnetoencephalography (MEG), diffusion tensor imaging (DTI), and resting-state fMRI] whether spastic CP is associated with functional and anatomical abnormalities in the sensorimotor network. Ten children participated in the study: four with diplegic CP (DCP), three with hemiplegic CP (HCP), and three typically developing (TD) children. Somatosensory (SS)-evoked fields (SEFs) were recorded in response to pneumatic stimuli applied to digits D1, D3, and D5 of both hands. Several parameters of water diffusion were calculated from DTI between the thalamus and the pre-central and post-central gyri in both hemispheres. The sensorimotor resting-state networks (RSNs) were examined by using an independent component analysis method. Tactile stimulation of the fingers elicited the first prominent cortical response at ~50 ms, in all except one child, localized over the primary SS cortex (S1). In five CP children, abnormal somatotopic organization was observed in the affected (or more affected) hemisphere. Euclidean distances were markedly different between the two hemispheres in the HCP children, and between DCP and TD children for both hemispheres. DTI analysis revealed decreased fractional anisotropy and increased apparent diffusion coefficient for the thalamocortical pathways in the more affected compared to less affected hemisphere in CP children. Resting-state functional MRI results indicated absent and/or abnormal sensorimotor RSNs for children with HCP and DCP consistent with the severity and location of their lesions. Our findings suggest an abnormal SS processing mechanism in the sensorimotor network of children with CP possibly as a result of diminished thalamocortical projections.
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