Evidence map›Paper›PMID 25309372›Full record

ArticleFrontiers in behavioral neuroscience2014

Effects of psychotropic agents on extinction of lever-press avoidance in a rat model of anxiety vulnerability.

Xilu Jiao, Kevin D Beck, Amanda L Stewart, Ian M Smith, Catherine E Myers, Richard J Servatius, Kevin C H Pang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in behavioral neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Xilu JiaoNeurobehavioral Research Laboratory, Veteran Affairs New Jersey Health Care System, VA Medical Center , East Orange, NJ , USA ; Stress and Motivated Behavior Institute, Rutgers - New Jersey Medical School, Rutgers Biomedical and Health Sciences, The State University of New Jersey , Newark, NJ , USA ; Veterans Bio-Medical Research Institute (VBRI), VA Medical Center , East Orange, NJ , USA.
Kevin D BeckNeurobehavioral Research Laboratory, Veteran Affairs New Jersey Health Care System, VA Medical Center , East Orange, NJ , USA ; Stress and Motivated Behavior Institute, Rutgers - New Jersey Medical School, Rutgers Biomedical and Health Sciences, The State University of New Jersey , Newark, NJ , USA ; Department of Neurology and Neurosciences, Rutgers - New Jersey Medical School, Rutgers Biomedical and Health Sciences, The State University of New Jersey , Newark, NJ , USA.
Amanda L StewartVeterans Bio-Medical Research Institute (VBRI), VA Medical Center , East Orange, NJ , USA.
Ian M SmithNeurobehavioral Research Laboratory, Veteran Affairs New Jersey Health Care System, VA Medical Center , East Orange, NJ , USA ; Veterans Bio-Medical Research Institute (VBRI), VA Medical Center , East Orange, NJ , USA.
Catherine E MyersNeurobehavioral Research Laboratory, Veteran Affairs New Jersey Health Care System, VA Medical Center , East Orange, NJ , USA ; Stress and Motivated Behavior Institute, Rutgers - New Jersey Medical School, Rutgers Biomedical and Health Sciences, The State University of New Jersey , Newark, NJ , USA ; Department of Neurology and Neurosciences, Rutgers - New Jersey Medical School, Rutgers Biomedical and Health Sciences, The State University of New Jersey , Newark, NJ , USA.
Richard J ServatiusNeurobehavioral Research Laboratory, Veteran Affairs New Jersey Health Care System, VA Medical Center , East Orange, NJ , USA ; Stress and Motivated Behavior Institute, Rutgers - New Jersey Medical School, Rutgers Biomedical and Health Sciences, The State University of New Jersey , Newark, NJ , USA ; Department of Neurology and Neurosciences, Rutgers - New Jersey Medical School, Rutgers Biomedical and Health Sciences, The State University of New Jersey , Newark, NJ , USA.
Kevin C H PangNeurobehavioral Research Laboratory, Veteran Affairs New Jersey Health Care System, VA Medical Center , East Orange, NJ , USA ; Stress and Motivated Behavior Institute, Rutgers - New Jersey Medical School, Rutgers Biomedical and Health Sciences, The State University of New Jersey , Newark, NJ , USA ; Department of Neurology and Neurosciences, Rutgers - New Jersey Medical School, Rutgers Biomedical and Health Sciences, The State University of New Jersey , Newark, NJ , USA.
Rutgers HealthNeurobehavioral Research (United States) · USRutgers, The State University of New Jersey · USVeterans Biomedical Research Institute · US

Funding

Role of the medial septum in perseverative behaviorsR01NS044373 · NINDS · VETERANS BIOMEDICAL RESEARCH INSTITUTE · PI PANG, KEVIN C.H. · 2002 to 2012
$2.1M
Impaired attention & hippocampal dysfunction in developing abnormal avoidanceI01BX000132 · VA · VA NEW JERSEY HEALTH CARE SYSTEM · PI PANG, KEVIN C.H. · 2009 to 2019
–
Neural mechanisms of extinction-resistant avoidance behaviorI01BX000218 · VA · VA NEW JERSEY HEALTH CARE SYSTEM · PI BECK, KEVIN D. · 2011 to 2013
–
BLRD VA I01 BX000132BLRD VA I01 BX000218NINDS NIH HHS R01 NS044373
6 · The paper itself

Abstract

Avoidance and its perseveration represent key features of anxiety disorders. Both pharmacological and behavioral approaches (i.e., anxiolytics and extinction therapy) have been utilized to modulate avoidance behavior in patients. However, the outcome has not always been desirable. Part of the reason is attributed to the diverse neuropathology of anxiety disorders. Here, we investigated the effect of psychotropic drugs that target various monoamine systems on extinction of avoidance behavior using lever-press avoidance task. Here, we used the Wistar-Kyoto (WKY) rat, a unique rat model that exhibits facilitated avoidance and extinction resistance along with malfunction of the dopamine (DA) system. Sprague Dawley (SD) and WKY rats were trained to acquire lever-press avoidance. WKY rats acquired avoidance faster and to a higher level compared to SD rats. During pharmacological treatment, bupropion and desipramine (DES) significantly reduced avoidance response selectively in WKY rats. However, after the discontinuation of drug treatment, only those WKY rats that were previously treated with DES exhibited lower avoidance response compared to the control group. In contrast, none of the psychotropic drugs facilitated avoidance extinction in SD rats. Instead, DES impaired avoidance extinction and increased non-reinforced response in SD rats. Interestingly, paroxetine, a widely used antidepressant and anxiolytic, exhibited the weakest effect in WKY rats and no effects at all in SD rats. Thus, our data suggest that malfunctions in brain catecholamine system could be one of the underlying etiologies of anxiety-like behavior, particularly avoidance perseveration. Furthermore, pharmacological manipulation targeting DA and norepinephrine may be more effective to facilitate extinction learning in this strain. The data from the present study may shed light on new pharmacological approaches to treat patients with anxiety disorders who are not responding to serotonin re-uptake inhibitors.

Indexed as

anxiolyticavoidance perseverationbehavioral inhibitiondopaminenorepinephrineserotonintransporter inhibitors

Identifiers

PMID25309372
PMCPMC4163983
OpenAlexW2130411597

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.