Evidence map›Paper›PMID 25309103›Full record

ArticleMacromolecular symposia2013

Hydrolytically degradable thiol-ene hydrogels for protein release.

Matthew S Rehmann, Andrew C Garibian, April M Kloxin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Macromolecular symposia, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Thiol-ene click hydrogels for therapeutic delivery.ACS biomaterials science & engineering · 2016
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Matthew S RehmannDepartment of Chemical & Biomolecular Engineering, University of Delaware, 150 Academy Street, Colburn Laboratory, Newark, Delaware, U.S.A. 19716.
Andrew C GaribianDepartment of Chemical & Biomolecular Engineering, University of Delaware, 150 Academy Street, Colburn Laboratory, Newark, Delaware, U.S.A. 19716.
April M KloxinDepartment of Chemical & Biomolecular Engineering, University of Delaware, 150 Academy Street, Colburn Laboratory, Newark, Delaware, U.S.A. 19716 ; Department of Materials Science & Engineering, University of Delaware, Newark, Delaware, U.S.A. 19716.

Funding

UDE COBRE: STRAINED MOLECULES FOR SYNTHESIS OF UNNATURAL AMINO ACIDSP20RR017716 · NCRR · UNIVERSITY OF DELAWARE · PI SULLIVAN, MILLICENT O · 2002 to 2011
$16.9M
CHEMISTRY-BIOLOGY INTERFACE PREDOCTORAL TRAININGT32GM008550 · NIGMS · UNIVERSITY OF DELAWARE · PI BAHNSON, BRIAN J · 1994 to 2018
$5.0M
NCRR NIH HHS P20 RR017716NIGMS NIH HHS T32 GM008550
6 · The paper itself

Abstract

A new degradable PEG-diester-dinorbornene/PEG-triester-trithiol hydrogel was evaluated for protein release. The hydrogel polymerized rapidly with seconds of UV irradiation and subsequently hydrolytically degraded in aqueous buffer over the course of approximately 3 weeks. Further, the hydrogel enabled the encapsulation and release of a model protein, bovine serum albumin (BSA), over 7 days with ~ 90% released at 48 h. This study serves as a proof-of-concept for the creation of hydrolytically degradable, PEG-ester-thiol-based hydrogels by a photoinitiated step growth mechanism for protein release. With this approach, degradation and release rates could be tuned by varying the monomer molecular weight and functionality in future studies.

Indexed as

degradationdrug delivery systemshydrogelsphotopolymerizationthiol–ene

Identifiers

PMID25309103
PMCPMC4193501

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.