ReviewWorld journal of gastroenterology2014
Probiotics against neoplastic transformation of gastric mucosa: effects on cell proliferation and polyamine metabolism.
Review in World journal of gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 67 citations in OpenAlex.
- Gastric Microbiota Dysbiosis and Microbiome-Based Interventions in Chronic Atrophic Gastritis.Nutrients · 2026Review
- Alteration of serum levels of tumour necrosis factor-a (TNF-a), interleukin-6 (IL-6), C-reactive protein (CRP), gastrin (GAS) and motilin (MTL) after treatment in the Helicobacter pylori-positive gastric ulcer.Journal of medical biochemistry · 2025Article
- MicroRNA: trends in clinical trials of cancer diagnosis and therapy strategies.Experimental & molecular medicine · 2023Review
- Recent Perspective ofAntioxidants (Basel, Switzerland) · 2023Review
- Alterations in the gastric microbiota and metabolites in gastric cancer: An update review.Frontiers in oncology · 2022Review
- Modulation of Stem Cell Progeny by Probiotics during Regeneration of Gastric Mucosal Erosions.Biology · 2021Article
- An Update on the Effects of Probiotics on Gastrointestinal Cancers.Frontiers in pharmacology · 2021Review
- Pathways of Gastric Carcinogenesis,International journal of molecular sciences · 2020Review
- The Effect ofIranian journal of medical sciences · 2020Article
- Network construction of gastric microbiome and organization of microbial modules associated with gastric carcinogenesis.Scientific reports · 2019Article
- Probiotics Upregulate Trefoil Factors and Downregulate Pepsinogen in the Mouse Stomach.International journal of molecular sciences · 2019Article
- What We Know and What We Need to Know about Aromatic and Cationic Biogenic Amines in the Gastrointestinal Tract.Foods (Basel, Switzerland) · 2018Review
- Probiotics and their role in gastrointestinal cancers prevention and treatment; an overview.Gastroenterology and hepatology from bed to bench · 2018Review
- Protective Effect of Lactobacillus casei on DMH-Induced Colon Carcinogenesis in Mice.Probiotics and antimicrobial proteins · 2017Article
- ABCG2 confers promotion in gastric cancer through modulating downstream CRKL in vitro combining with biostatistics mining.Oncotarget · 2017Article
- Potential role of probiotics in the management of gastric ulcer.Experimental and therapeutic medicine · 2016Article
- Different gastric microbiota compositions in two human populations with high and low gastric cancer risk in Colombia.Scientific reports · 2016Article
- SLC7A5 Functions as a Downstream Target Modulated by CRKL in Metastasis Process of Gastric Cancer SGC-7901 Cells.PloS one · 2016Article
- Fermented Foods: Are They Tasty Medicines for Helicobacter pylori Associated Peptic Ulcer and Gastric Cancer?Frontiers in microbiology · 2016Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gastric cancer is still the second leading cause of cancer death worldwide, accounting for about 10% of newly diagnosed neoplasms. In the last decades, an emerging role has been attributed to the relations between the intestinal microbiota and the onset of both gastrointestinal and non-gastrointestinal neoplasms. Thus, exogenous microbial administration of peculiar bacterial strains (probiotics) has been suggested as having a profound influence on multiple processes associated with a change in cancer risk. The internationally accepted definition of probiotics is live microorganisms that, when administered in adequate amounts, confer a health benefit on the host. The possible effects on the gastrointestinal tract following probiotic administration have been investigated in vitro and in animal models, as well as in healthy volunteers and in patients suffering from different human gastrointestinal diseases. Although several evidences are available on the use of probiotics against the carcinogen Helicobacter pylori, little is still known about the potential cross-interactions among probiotics, the composition and quality of intestinal flora and the neoplastic transformation of gastric mucosa. In this connection, a significant role in cell proliferation is played by polyamines (putrescine, spermidine, and spermine). These small amines are required in both pre-neoplastic and neoplastic tissue to sustain the cell growth and the evidences here provided suggest that probiotics may act as antineoplastic agents in the stomach by affecting also the polyamine content and functions. This review will summarize data on the most widely recognized effects of probiotics against neoplastic transformation of gastric mucosa and in particular on their ability in modulating cell proliferation, paying attention to the polyamine metabolism.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.