SynthesisJournal of neurology2015
Post-stroke depression and lesion location: a systematic review.
Synthesis in Journal of neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
77 citing papers in PubMed, 8 syntheses or guidelines pooled it, 185 citations in OpenAlex.
- Post-Stroke Depression and Determinants in Ethiopia; A Systematic Review and Meta-Analysis.International journal of methods in psychiatric research · 2026Pooled it
- Exploring the occurence and risk factors of post-stroke depression among stroke survivors in Africa: a comprehensive systematic review and meta-analysis.BMC public health · 2025Pooled it
- Return to Work After Ischemic Stroke in Young Adults: A Multicenter Cohort Study, Systematic Review, and Meta-Analysis.Journal of the American Heart Association · 2025Pooled it
- A depression network caused by brain tumours.Brain structure & function · 2022Pooled it
- Effects of Noninvasive Brain Stimulation Combined With Antidepressants in Patients With Poststroke Depression: A Systematic Review and Meta-Analysis.Frontiers in pharmacology · 2022Pooled it
- Role of social support in poststroke depression: A meta-analysis.Frontiers in psychiatry · 2022Pooled it
- The association between lesion location, sex and poststroke depression: Meta-analysis.Brain and behavior · 2017Pooled it
- Imaging Markers of Post-Stroke Depression and Apathy: a Systematic Review and Meta-Analysis.Neuropsychology review · 2017Pooled it
- Intracerebral haemorrhage laterality and associations with mood and pain: a MISTIE III substudy.Stroke and vascular neurology · 2025Trial
- Depression is an independent risk factor for stroke reccurence and cognitive impairment in stroke patients.Translational psychiatry · 2025Trial
- Quality of Life in Physical, Social, and Cognitive Domains Improves With Endovascular Therapy in the DEFUSE 3 Trial.Stroke · 2021Trial
- Trial
- Dynamic Hemispheric Lateralization of Naturalistic Emotional Processing After Unilateral Stroke: An EEG Study.CNS neuroscience & therapeutics · 2026Article
- Prevalence and factors associated with post-stroke depression: a cross-sectional analysis of a prospectively assembled cohort in Eastern Saudi Arabia.Frontiers in neurology · 2026Article
- The Immunologic Underpinnings of Post-Stroke Depression.Biological psychiatry global open science · 2025Review
- Diagnosis and etiology of poststroke depression: A review.World journal of psychiatry · 2025Review
- Psychiatric symptoms in stroke patients: Clinical features of depression and anxiety.World journal of psychiatry · 2025Article
- Prevalence and Associated Factors of Depression in Patients with Ischaemic Stroke: A Cross-Sectional Study.Neuropsychiatric disease and treatment · 2025Article
- Advancing Post-Stroke Depression Research: Insights from Murine Models and Behavioral Analyses.Life (Basel, Switzerland) · 2024Review
- Post-stroke arrhythmia could be a potential predictor for post-stroke depression.Scientific reports · 2024Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Post-stroke depression (PSD) is a frequent problem in stroke rehabilitation. Several studies have evaluated association between the lesion location and the risk of depression. Different conclusions and contradictory findings have been published. The aim of the present study was to perform a systematic meta-analysis to evaluate the relationship between PSD and lesion location. We researched PubMed, ISI Web of Science, EMBASE, and systematically reviewed available publications reporting investigations on stroke location and risk of PSD. Subgroup analyses were performed according to the time since stroke onset to assessment for PSD or the source of patients. Odds ratios (ORs) and 95 % confidence intervals (CIs) were used for pooled analyses. Heterogeneity was assessed with Cochran's Q test and I (2) test. Begg's funnel plot and Egger's test were used to examine the publication bias. A total of 43 studies involving 5,507 patients suffering from stroke were included in this meta-analysis. The pooled OR with 95 % CI for the overall association of stroke location and depression risk was 0.99 (0.88-1.11). Subgroups analyses highlighted that only studies with subacute post-stroke group (1-6 months) showed a statistical association between right hemisphere stroke and risk of depression (OR = 0.79, 95 % CI 0.66-0.93). This systematic review offered no support for the hypothesis that lesion of the left hemisphere was associated with an increased risk of depression after stroke. We only find significant association between right hemisphere stroke and incidence of depression for studies within subacute post-stroke phase.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.