ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2015
Smoking restores impaired LTD-like plasticity in schizophrenia: a transcranial direct current stimulation study.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- The two-way relationship between nicotine and cortical activity: a systematic review of neurobiological and treatment aspects.European archives of psychiatry and clinical neuroscience · 2021Pooled it
- Motor cortical plasticity in schizophrenia: A meta-analysis of Transcranial Magnetic Stimulation - Electromyography studies.Schizophrenia research · 2019Pooled it
- Moderating Role of Cigarette Smoking on the Efficacy of tDCS in the Treatment of Negative and Cognitive Symptoms of Schizophrenia: Results from a Randomized Clinical Trial.Brain sciences · 2026Article
- Elevated mirror neuron system activity in bipolar mania: Evidence from a transcranial magnetic stimulation study.Bipolar disorders · 2019Article
- Modulating Neural Circuits with Transcranial Magnetic Stimulation: Implications for Addiction Treatment Development.Pharmacological reviews · 2018Review
- Altered Motor-Striatal Plasticity and Cortical Functioning in Patients with Schizophrenia.Neuroscience bulletin · 2017Article
- Review
- Compromised neuroplasticity in cigarette smokers under nicotine withdrawal is restituted by the nicotinic αScientific reports · 2017Article
- Potentiation of M1 Muscarinic Receptor Reverses Plasticity Deficits and Negative and Cognitive Symptoms in a Schizophrenia Mouse Model.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
- [Non-invasive brain stimulation for treatment of schizophrenic psychoses].Der Nervenarzt · 2015Review
- The effects of medication use in transcranial direct current stimulation: A brief review.Brain stimulationReview
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Impaired neuroplastic responses following noninvasive brain stimulation have been reported repeatedly in schizophrenia patients. These findings have been associated with deficits in GABAergic, glutamatergic, and cholinergic neurotransmission. Although various neurophysiological studies have indicated a relationship between nicotine and neuroplasticity in healthy individuals, the present study is the first investigation into the impact of nicotine on LTD-like plasticity in patients with schizophrenia. Cortical excitability and cortical plasticity were explored in 30 schizophrenia patients (17 smoker, 13 nonsmoker) and 45 healthy controls (13 smoker, 32 nonsmoker) by using single-pulse transcranial magnetic stimulation (TMS) before and following cathodal transcranial direct current stimulation (tDCS) applied to the left primary motor cortex. Our analysis revealed abolished LTD-like plasticity in nonsmoking schizophrenia patients. However, these plasticity deficits were not present in smoking schizophrenia patients. In healthy controls, significant MEP reductions following cathodal tDCS were observed in nonsmoking individuals, but only trend-level reductions in smokers. In smoking schizophrenia patients, the severity of negative symptoms correlated positively with reduced neuroplasticity, whereas nonsmoking patients displayed the opposite effect. Taken together, the data of our study support the notion of an association between chronic smoking and the restitution of impaired LTD-like plasticity in schizophrenia patients. Although replication and further research are needed to better understand this relationship, our findings indicate that nicotine intake might stabilize the impaired inhibition-facilitation balance in the schizophrenic brain through a complex interaction between cortical plasticity, and GABAergic and cholinergic neurotransmission, and might explain the reduced prevalence of negative symptoms in this population.
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