ArticleImmunity2014
Autophagy gene Atg16L1 prevents lethal T cell alloreactivity mediated by dendritic cells.
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Article in Immunity, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
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64citing papers in PubMed
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Who cites it
64 citing papers in PubMed.
- Emerging Insights into the Interplay Between PANoptosis and Autophagy in Immune Regulation and Immune-Mediated Inflammatory Diseases.Medical sciences (Basel, Switzerland) · 2025Review
- C10ORF99 (GPR15L) increases susceptibility to colitis and colitis-induced colorectal cancer via GPR15-independent mechanisms, while mediating GPR15-dependent T cell migration to the large intestine.Mucosal immunology · 2025Article
- Role of autophagy in rejection after solid organ transplantation: A systematic review of the literature.World journal of transplantation · 2025Review
- Machine learning based screening of biomarkers associated with cell death and immunosuppression of multiple life stages sepsis populations.Scientific reports · 2025Article
- The reciprocal regulation between autophagy and IL-22: implications for immunity and therapy.Clinical and experimental medicine · 2025Review
- Autophagy as a potential therapeutic target in regulating improper cellular proliferation.Frontiers in pharmacology · 2025Review
- Stage-specific autophagy dynamics in reproductive processes and associated disorders.Frontiers in cell and developmental biology · 2025Review
- Autophagy differentially regulates tissue tolerance of distinct target organs in graft-versus-host disease models.The Journal of clinical investigation · 2024Article
- Inhibition of RIP1 improves immune reconstitution and reduces GVHD mortality while preserving graft-versus-leukemia effects.Science translational medicine · 2023Article
- The crosslinks between ferroptosis and autophagy in asthma.Frontiers in immunology · 2023Review
- Autophagy and Its Lineage-Specific Roles in the Hematopoietic System.Oxidative medicine and cellular longevity · 2023Review
- Canonical and Non-Canonical Functions of the Autophagy Machinery in MHC Restricted Antigen Presentation.Frontiers in immunology · 2022Review
- Interactions of Autophagy and the Immune System in Health and Diseases.Autophagy reports · 2022Article
- ATG16L1 is a Potential Prognostic Biomarker and Immune Signature for Osteosarcoma: A Study Based on Bulk RNA and Single-Cell RNA-Sequencing.International journal of general medicine · 2022Article
- The role of carbonic anhydrase III and autophagy in type 2 diabetes with cardio-cerebrovascular disease.Metabolic brain disease · 2021Article
- Genetic variants associated with inflammatory bowel disease and gut graft-versus-host disease.Blood advances · 2021Article
- Review
- USP19 suppresses inflammation and promotes M2-like macrophage polarization by manipulating NLRP3 function via autophagy.Cellular & molecular immunology · 2021Article
- High Throughput Analysis Reveals Changes in Gut Microbiota and Specific Fecal Metabolomic Signature in Hematopoietic Stem Cell Transplant Patients.Microorganisms · 2021Article
- Article
4 more citing papers are in PubMed but not listed here.
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Authors and funding
19 authors.
Vanessa M Hubbard-LuceyKimmel Center for Biology and Medicine at the Skirball Institute, New York, NY 10016, USA; Department of Microbiology, New York University School of Medicine, New York, NY 10016, USA.
Yusuke ShonoDepartment of Immunology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Katie MaurerKimmel Center for Biology and Medicine at the Skirball Institute, New York, NY 10016, USA; Sackler Institute of Graduate Biomedical Sciences, New York University School of Medicine, New York, NY 10016, USA.
Mallory L WestDepartment of Immunology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Natalie V SingerDepartment of Immunology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Carly G K ZieglerDepartment of Computational Biology and Immunology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Cecilia LezcanoProgram in Dermatopathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Ana Carolina Fragoso MottaProgram in Dermatopathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Karin SchmidDepartment of Haematology and Oncology, University Medical Centre University of Regensburg, Regensburg, 93053, Germany.
Samuel M LeviDepartment of Chemistry, University of Pennsylvania, Philadelphia, PA, 19104, USA.
George F MurphyProgram in Dermatopathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Chen LiuDepartment of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL 32611, USA.
Jeffrey D WinklerDepartment of Chemistry, University of Pennsylvania, Philadelphia, PA, 19104, USA; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104, USA.
Ravi K AmaravadiAbramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Gerhard RoglerDepartment of Gastroenterology, University Hospital Zürich, Rämistrasse 100, 8006 Zurich, Switzerland.
Anne M DickinsonHaematological Sciences, Institute of Cellular Medicine, Newcastle University, NE2 4HH Tyne and Wear, UK.
Ernst HollerDepartment of Haematology and Oncology, University Medical Centre University of Regensburg, Regensburg, 93053, Germany.
Marcel R M van den BrinkDepartment of Immunology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address: vandenbm@mskcc.org.
Ken CadwellKimmel Center for Biology and Medicine at the Skirball Institute, New York, NY 10016, USA; Department of Microbiology, New York University School of Medicine, New York, NY 10016, USA. Electronic address: ken.cadwell@med.nyu.edu.
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4MVaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ANIRBAN MAITRA · 1985 to 2026
$83.1MT LYMPHOCYTE SUBSET FUNCTION POST-TRANSPLANTATIONP01CA023766 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI PERALES, MIGUEL-ANGEL · 1985 to 2023
$59.0MTargeting the MAP and PI3 Kinase Pathways in MelanomaP01CA114046 · NCI · WISTAR INSTITUTE · PI MURPHY, MAUREEN E. · 2008 to 2023
$37.1MMEDICAL SCIENTIST TRAININGT32GM007308 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI PHILIPS, MARK REID · 1985 to 2019
$23.2MTREATMENT OF CANCER PATIENTS WITH THYMIC FACTORSP01CA033049 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SCHEINBERG, DAVID A · 1985 to 2009
$19.8MTRAINING PROGRAM: MECHANISMS OF VIRUS-HOST INTERACTIONST32AI007647 · NIAID · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI Domenico Tortorella · 2000 to 2026
$11.5MDiabetes, Digestive, and Kidney Diseases Extramural ResearchR01DK093668 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI Ken Hashigiwa Cadwell · 2011 to 2026
$7.3MStrategies to enhance immune reconstitution after bone marrow transplantR01HL069929 · NHLBI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI VAN DEN BRINK, MARCEL R M · 2002 to 2015
$7.0MTraining Program in Immunology and Inflammation.T32AI100853 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Susan Ruth Schwab · 2012 to 2026
$4.5MStrategies to Enhance Lymphoid Recovery After Radiation-Induced InjuryR01AI080455 · NIAID · SLOAN-KETTERING INST CAN RESEARCH · PI VAN DEN BRINK, MARCEL R M · 2008 to 2012
$2.6MIL-22 in Thymic RegenerationR01AI101406 · NIAID · SLOAN-KETTERING INST CAN RESEARCH · PI VAN DEN BRINK, MARCEL R M · 2012 to 2016
$2.5MNCI NIH HHS 5P30CA016087-33NCI NIH HHS P01 CA023766NCI NIH HHS P01 CA033049NCI NIH HHS P01 CA114046NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA016087NCRR NIH HHS RR023704-01A1NCRR NIH HHS S10 RR023704NHLBI NIH HHS F32 HL115974NHLBI NIH HHS R01 HL069929NIAID NIH HHS AI100288NIAID NIH HHS R01 AI080455NIAID NIH HHS R01 AI100288NIAID NIH HHS R01 AI101406NIAID NIH HHS T32 AI007647NIAID NIH HHS T32 AI100853NIDDK NIH HHS F30 DK098925NIDDK NIH HHS R01 DK093668NIGMS NIH HHS T32 GM007308NIGMS NIH HHS T32 GM0738
Abstract
Atg16L1 mediates the cellular degradative process of autophagy and is considered a critical regulator of inflammation based on its genetic association with inflammatory bowel disease. Here we find that Atg16L1 deficiency leads to an exacerbated graft-versus-host disease (GVHD) in a mouse model of allogeneic hematopoietic stem cell transplantation (allo-HSCT). Atg16L1-deficient allo-HSCT recipients with GVHD displayed increased T cell proliferation due to increased dendritic cell (DC) numbers and costimulatory molecule expression. Reduced autophagy within DCs was associated with lysosomal abnormalities and decreased amounts of A20, a negative regulator of DC activation. These results broaden the function of Atg16L1 and the autophagy pathway to include a role in limiting a DC-mediated response during inflammatory disease, such as GVHD.
Indexed as
AnimalsAutophagyAutophagy-Related ProteinsB7-1 AntigenB7-2 AntigenCarrier ProteinsCD40 AntigensCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell ProliferationCells, CulturedColitisCysteine EndopeptidasesDendritic CellsDisease Models, AnimalFemaleAtg16l1 protein, mouseAutophagy-Related ProteinsB7-1 AntigenB7-2 AntigenCarrier ProteinsCD40 AntigensCd86 protein, mouseCysteine EndopeptidasesGranulocyte-Macrophage Colony-Stimulating FactorHomeodomain ProteinsImmediate-Early ProteinsIntracellular Signaling Peptides and ProteinsLaptm5 protein, mouseMembrane ProteinsRAG-1 proteinReceptors, Antigen, T-Cell, gamma-deltaTnfaip3 protein, mouseTumor Necrosis Factor alpha-Induced Protein 3
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.