ArticleEvolution; international journal of organic evolution2014
Cold adaptation shapes the robustness of metabolic networks in Drosophila melanogaster.
Article in Evolution; international journal of organic evolution, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 72 citations in OpenAlex.
- Metabolism dynamics in tropical cockroach during a cold-induced recovery period.Biological research · 2025Article
- Article
- Evolutionary Adaptation of Protein Turnover in White Muscle of Stenothermal Antarctic Fish: Elevated Cold Compensation at Reduced Thermal Responsiveness.Biomolecules · 2023Article
- Exercise and/or Cold Exposure Alters the Gene Expression Profile in the Fat Body and Changes the Heart Function inFrontiers in endocrinology · 2022Article
- Clinal variation as a tool to understand climate change.Frontiers in physiology · 2022Review
- Intestinal Flora-Derived Kynurenic Acid Protects Against Intestinal Damage Caused byFrontiers in microbiology · 2022Article
- Sestrin regulates acute chill coma recovery in Drosophila melanogaster.Insect biochemistry and molecular biology · 2021Article
- Temperature, rainfall and wind variables underlie environmental adaptation in natural populations of Drosophila melanogaster.Molecular ecology · 2021Article
- Transcriptome analysis ofEcology and evolution · 2020Article
- Intraspecific variation in thermal acclimation and tolerance between populations of the winter ant,Ecology and evolution · 2020Article
- Three Quantitative Trait Loci Explain More than 60% of Variation for Chill Coma Recovery Time in a Natural Population ofG3 (Bethesda, Md.) · 2019Article
- Integration of transcriptomic data in a genome-scale metabolic model to investigate the link between obesity and breast cancer.BMC bioinformatics · 2019Article
- Cold adaptation does not alter ATP homeostasis during cold exposure in Drosophila melanogaster.Integrative zoology · 2018Article
- Cold Acclimation Favors Metabolic Stability inFrontiers in physiology · 2018Article
- Methods for studying the metabolic basis of Drosophila development.Wiley interdisciplinary reviews. Developmental biology · 2017Review
- Metabolomic Studies inGenetics · 2017Review
- Considerations when choosing a genetic model organism for metabolomics studies.Current opinion in chemical biology · 2017Review
- Evolution of the metabolome in response to selection for increased immunity in populations of Drosophila melanogaster.PloS one · 2017Article
- Metabolomics with Nuclear Magnetic Resonance Spectroscopy in a Drosophila melanogaster Model of Surviving Sepsis.Metabolites · 2016Article
- Head Transcriptomes of Two Closely Related Species of Fruit Flies of the Anastrepha fraterculus Group Reveals Divergent Genes in Species with Extensive Gene Flow.G3 (Bethesda, Md.) · 2016Article
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Authors and funding
8 authors at 7 institutions in 2 countries.
Funding
Abstract
When ectotherms are exposed to low temperatures, they enter a cold-induced coma (chill coma) that prevents resource acquisition, mating, oviposition, and escape from predation. There is substantial variation in time taken to recover from chill coma both within and among species, and this variation is correlated with habitat temperatures such that insects from cold environments recover more quickly. This suggests an adaptive response, but the mechanisms underlying variation in recovery times are unknown, making it difficult to decisively test adaptive hypotheses. We use replicated lines of Drosophila melanogaster selected in the laboratory for fast (hardy) or slow (susceptible) chill-coma recovery times to investigate modifications to metabolic profiles associated with cold adaptation. We measured metabolite concentrations of flies before, during, and after cold exposure using nuclear magnetic resonance (NMR) spectroscopy to test the hypotheses that hardy flies maintain metabolic homeostasis better during cold exposure and recovery, and that their metabolic networks are more robust to cold-induced perturbations. The metabolites of cold-hardy flies were less cold responsive and their metabolic networks during cold exposure were more robust, supporting our hypotheses. Metabolites involved in membrane lipid synthesis, tryptophan metabolism, oxidative stress, energy balance, and proline metabolism were altered by selection on cold tolerance. We discuss the potential significance of these alterations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.