Evidence map›Paper›PMID 25307979›Full record

Trial reportJournal of critical care2015

Neuromuscular electrical stimulation in mechanically ventilated patients: a randomized, sham-controlled pilot trial with blinded outcome assessment.

Michelle E Kho, Alexander D Truong, Jennifer M Zanni, Nancy D Ciesla, Roy G Brower, Jeffrey B Palmer, Dale M Needham

5 registry-linked trialsOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of critical care, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 58 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 8 pooled it
7.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00709124 nacompletednot on this map

Use of Neuromuscular Electrostimulation (NMES) for Treatment or Prevention of ICU-Associated Weakness

TypeinterventionalSponsorJohns Hopkins UniversityRan2008 to 2013Enrolled36ConditionsIntensive Care Unit, Muscle WeaknessArmsNeuromuscular Electrostimulation (NMES) CareStim Muscle Stimulation Device (Care Rehab, McLean, VA), Sham
NCT02391103 nacompletednot on this map

Effects of Neuromuscular Electrical Stimulation on Muscle Mass and Strength in Critically Ill Patients After Cardiothoracic Surgery. An Ultrasound-Based Randomized Controlled Trial

TypeinterventionalSponsorMedical University of ViennaRan2011 to 2015Enrolled54ConditionsNeuromuscular Electrical Stimulation, Intensive Care Unit Acquired Weakness, Muscle Wasting, Muscle LossArmsCompex 3 Professional (CefarCompex Medical AB) stimulator, sham-stimulation
NCT03021902 phase2completednot on this mapstarted 2017, after this paper: background citation

Nutrition and Exercise in Critical Illness (The NEXIS Trial): A Randomized Trial of Combined Cycle Ergometry and Amino Acids in the ICU

TypeinterventionalSponsorClinical Evaluation Research Unit at Kingston General HospitalRan2017 to 2025Enrolled115ConditionsAcute Respiratory FailureArmsIV amino acids, In-bed cycle ergometry exercise
NCT05053724 nacompletednot on this mapstarted 2018, after this paper: background citation

Efficacy of the "Start to Move" Protocol on Functionality, Delirium and Acquired Weakness in ICU. Randomized Clinical Trial.

TypeinterventionalSponsorHospital Felix BulnesRan2018 to 2019Enrolled69ConditionsIntensive Care Unit Acquired Weakness, Intensive Care Unit Delirium, Intensive Care Neuropathy, Intensive Care Unit SyndromeArmsStar to move Protocol
NCT07188350 narecruitingnot on this mapstarted 2025, after this paper: background citation

Neuromuscular Electrical Stimulation of Lower Limbs in Patients Undergoing Invasive Mechanical Ventilation: Randomized Clinical Trial

TypeinterventionalSponsorHospital Moinhos de VentoRan2025 to 2027Enrolled150ConditionsMechanical Ventilation, Critical Illness, Intensive Care Unit Patients, Muscle Weakness ConditionArmsConventional Physical Therapy, Neuromuscular Electrical Stimulation (NMES)
3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 8 syntheses or guidelines pooled it, 141 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Michelle E KhoDepartment of Physical Medicine and Rehabilitation, Johns Hopkins University, Baltimore, MD 21287; School of Rehabilitation Science, McMaster University, Hamilton, ON, Canada L8S 1C7. Electronic address: khome@mcmaster.ca.
Alexander D TruongPulmonary, Allergy, and Critical Care Medicine, Emory University, Atlanta, GA 30308.
Jennifer M ZanniDepartment of Physical Medicine and Rehabilitation, Johns Hopkins University, Baltimore, MD 21287; Department of Physical Medicine and Rehabilitation, Johns Hopkins Hospital, Baltimore, MD 21287; Outcomes After Critical Illness and Surgery (OACIS) Group, Johns Hopkins University, Baltimore, MD 21287.
Nancy D CieslaDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD 21287; Outcomes After Critical Illness and Surgery (OACIS) Group, Johns Hopkins University, Baltimore, MD 21287.
Roy G BrowerDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD 21287.
Jeffrey B PalmerDepartment of Physical Medicine and Rehabilitation, Johns Hopkins University, Baltimore, MD 21287.
Dale M NeedhamDepartment of Physical Medicine and Rehabilitation, Johns Hopkins University, Baltimore, MD 21287; Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD 21287; Outcomes After Critical Illness and Surgery (OACIS) Group, Johns Hopkins University, Baltimore, MD 21287.
Johns Hopkins University · USEmory University · USMcMaster University · CA

Funding

Institute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8M
Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
MULTIDISCIPLINARY TRAINING PROGRAM IN LUNG DISEASEST32HL007534 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Nadia N Hansel, Larissa A. Shimoda · 1985 to 2026
$28.3M
CIHRNCATS NIH HHS UL1 TR001079NCRR NIH HHS UL1 RR 025005NCRR NIH HHS UL1 RR025005NHLBI NIH HHS T32 HL007534NHLBI NIH HHS T32HL007534-31
6 · The paper itself

Abstract

purposeThe purpose of the study is to compare neuromuscular electrical stimulation (NMES) vs sham on leg strength at hospital discharge in mechanically ventilated patients. MATERIALS AND

methodsWe conducted a randomized pilot study of NMES vs sham applied to 3 bilateral lower extremity muscle groups for 60 minutes daily in the intensive care unit (ICU). Between June 2008 and March 2013, we enrolled adults who were receiving mechanical ventilation within the first week of ICU stay and who could transfer independently from bed to chair before hospital admission. The primary outcome was lower extremity muscle strength at hospital discharge using Medical Research Council score (maximum, 30). Secondary outcomes at hospital discharge included walking distance and change in lower extremity strength from ICU awakening. Clinicaltrials.gov: NCT00709124.

resultsWe stopped enrollment early after 36 patients due to slow patient accrual and the end of research funding. For NMES vs sham, mean (SD) lower extremity strength was 28 (2) vs 27 (3), P = .072. Among secondary outcomes, NMES vs sham patients had a greater mean (SD) walking distance (514 [389] vs 251 [210] ft, P = .050) and increase in muscle strength (5.7 [5.1] vs 1.8 [2.7], P = .019).

conclusionsIn this pilot randomized trial, NMES did not significantly improve leg strength at hospital discharge. Significant improvements in secondary outcomes require investigation in future research.

Indexed as

Respiration, ArtificialAdultAgedEarly Termination of Clinical TrialsElectric StimulationElectric Stimulation TherapyFemaleHumansIntensive Care UnitsLower ExtremityMaleMiddle AgedMuscle StrengthOutcome Assessment, Health CarePatient DischargePatient SelectionCritical illnessElectric stimulationIntensive care unitsMuscleRandomized controlled trialRespiration artificial

Identifiers

PMID25307979
PMCPMC4268169
OpenAlexW2145878627

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.