ArticleJournal of neural transmission (Vienna, Austria : 1996)2015
Stereological investigation of the posterior hippocampus in affective disorders.
Article in Journal of neural transmission (Vienna, Austria : 1996), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 4 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 4 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Hippocampus long-axis specialization throughout development: A meta-analysis.Human brain mapping · 2023Pooled it
- Glial Cell Abnormalities in Major Psychiatric Diseases: A Systematic Review of Postmortem Brain Studies.Molecular neurobiology · 2022Pooled it
- In vivo hippocampal subfield volumes in bipolar disorder-A mega-analysis from The Enhancing Neuro Imaging Genetics through Meta-Analysis Bipolar Disorder Working Group.Human brain mapping · 2022Pooled it
- The neuropathology of bipolar disorder: systematic review and meta-analysis.Molecular psychiatry · 2020Pooled it
- Increased hippocampal tail volume predicts depression status and remission to anti-depressant medications in major depression.Molecular psychiatry · 2018Trial
- Filling in the gap: Hippocampal CA1 neuronal counts and volumes in female cognitive controls.Neurobiology of disease · 2025Article
- Disturbed Oligodendroglial Maturation Causes Cognitive Dysfunction in Schizophrenia: A New Hypothesis.Schizophrenia bulletin · 2023Article
- Oligodendrocytes matter: a review of animal studies on early adversity.Journal of neural transmission (Vienna, Austria : 1996) · 2023Review
- Layer III pyramidal cells in the prefrontal cortex reveal morphological changes in subjects with depression, schizophrenia, and suicide.Translational psychiatry · 2022Article
- Glymphatic Dysfunction: A Bridge Between Sleep Disturbance and Mood Disorders.Frontiers in psychiatry · 2021Article
- Hippocampal Subfield Volumes in Major Depressive Disorder Adolescents with a History of Suicide Attempt.BioMed research international · 2021Article
- Astrocytes in Bipolar Disorder.Advances in neurobiology · 2021Article
- Affective Immunology: The Crosstalk Between Microglia and Astrocytes Plays Key Role?Frontiers in immunology · 2020Review
- Episodic recognition memory and the hippocampus in Parkinson's disease: A review.Cortex; a journal devoted to the study of the nervous system and behavior · 2019Review
- Neuron-glia Interaction as a Possible Pathophysiological Mechanism of Bipolar Disorder.Current neuropharmacology · 2018Review
- Synucleinopathies: common features and hippocampal manifestations.Cellular and molecular life sciences : CMLS · 2017Review
- Density of GFAP-immunoreactive astrocytes is decreased in left hippocampi in major depressive disorder.Neuroscience · 2016Article
- Reduced density of glutamine synthetase immunoreactive astrocytes in different cortical areas in major depression but not in bipolar I disorder.Frontiers in cellular neuroscience · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hippocampus volumes have been shown to be decreased in patients with major depression, but volume measurements are inconsistent in patients with bipolar disorder. Both disorders are associated with deficits in hippocampus-mediated cognitive functions. However, the underlying pathophysiology is widely unknown. In this post-mortem study, we used design-based stereology on Nissl-stained serial sections to investigate the number of neurons, oligodendrocytes and astrocytes in substructures of the posterior hippocampus in eight patients with major depression, eight patients with bipolar disorder and ten control patients without a neuropsychiatric disorder. Compared to controls, patients with bipolar disorder had significantly more neurons in the cornu ammonis subfield 1 (CA1) and the subiculum, while the number of oligodendrocytes was higher only in CA1. In patients with major depression, the density of oligodendrocytes was higher in CA2/3, CA4 and the subiculum. The dose of antidepressants correlated with the density and number of oligodendrocytes in CA2/3, indicating that antidepressants may affect our results. Treatment with neuroleptics expressed in chlorpromazine equivalents and benzodiazepines expressed in diazepam equivalents correlated negatively with the number of oligodendrocytes in CA2/3 and CA4, respectively, suggesting that treatment with these drugs do not influence cell number. We did not detect alterations in either volumes of substructures or numbers of astrocytes. Increased cell numbers argue for a denser packing of neurons and oligodendrocytes as a result of a decreased neuropils. This neuropathological process may be based on neurodevelopmental disturbances and may contribute to altered microconnectivity and cognitive deficits in affective disorders.
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Registered trials
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