ArticleScientific reports2014
Practical implementation, characterization and applications of a multi-colour time-gated luminescence microscope.
Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 60 citations in OpenAlex.
- Two-photon excited circularly polarized luminescence of hetero[9]helicene with multiresonant thermally activated delayed fluorescence.Nature communications · 2026Article
- Development of Time-Resolved Luminescence Measurement Instruments for Biosensing and Bioimaging - An Overview.Measurement : journal of the International Measurement Confederation · 2025Article
- A Simple Circuit for Time-Resolved Luminescence (TRL) Measurement Instruments: Demonstration Through a Smartphone-Based TRL Imager for Anticounterfeiting Application.IEEE sensors letters · 2025Article
- Dual-Mode Tumor Imaging Using Probes That Are Responsive to Hypoxia-Induced Pathological Conditions.Biosensors · 2022Review
- Lanthanide-Based Optical Probes of Biological Systems.Cell chemical biology · 2020Review
- Auto-Phase-Locked Time-Resolved Luminescence Detection: Principles, Applications, and Prospects.Frontiers in chemistry · 2020Review
- Dual-emissive nanoarchitecture of lanthanide-complex-modified silica particles forChemical science · 2017Article
- Background-free in-vivo Imaging of Vitamin C using Time-gateable Responsive Probe.Scientific reports · 2015Article
- Gated Luminescence Imaging of Silicon Nanoparticles.ACS nano · 2015Article
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Authors and funding
12 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Time-gated luminescence microscopy using long-lifetime molecular probes can effectively eliminate autofluorescence to enable high contrast imaging. Here we investigate a new strategy of time-gated imaging for simultaneous visualisation of multiple species of microorganisms stained with long-lived complexes under low-background conditions. This is realized by imaging two pathogenic organisms (Giardia lamblia stained with a red europium probe and Cryptosporidium parvum with a green terbium probe) at UV wavelengths (320-400 nm) through synchronization of a flash lamp with high repetition rate (1 kHz) to a robust time-gating detection unit. This approach provides four times enhancement in signal-to-background ratio over non-time-gated imaging, while the average signal intensity also increases six-fold compared with that under UV LED excitation. The high sensitivity is further confirmed by imaging the single europium-doped Y₂O₂S nanocrystals (150 nm). We report technical details regarding the time-gating detection unit and demonstrate its compatibility with commercial epi-fluorescence microscopes, providing a valuable and convenient addition to standard laboratory equipment.
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