Evidence map›Paper›PMID 25307683›Full record

ArticleThe Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases

Tuberculosis in HIV-infected infants, children, and adolescents in Latin America.

Margot R Krauss, D Robert Harris, Thalita Abreu, Fabiana G Ferreira, Noris Pavia Ruz, Carol Worrell, Rohan Hazra, NISDI Pediatric Study Group

Abstract read
In one paragraph

Article in The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Tuberculosis and HIV coinfection and related collaborative activities in Latin America and the Caribbean.Revista panamericana de salud publica = Pan American journal of public health · 2020
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Getting to 90-90-90 in paediatric HIV: What is needed?Journal of the International AIDS Society · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Margot R KraussWestat, Rockville, USA. Electronic address: Margotkrauss@westat.com.
D Robert HarrisWestat, Rockville, USA.
Thalita AbreuInstituto de Puericultura e Pediatria Martagão Gesteira, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Fabiana G FerreiraUniversidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Noris Pavia RuzHospital Infantil de Mexico Federico Gomez, Mexico City, Mexico.
Carol WorrellEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Bethesda, USA.
Rohan HazraEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Bethesda, USA.
NISDI Pediatric Study Group

Funding

NICHD NIH HHS N01-HD-8-0001NIDDK NIH HHS HHSN267200800001C
6 · The paper itself

Abstract

objectiveTo evaluate the occurrence, clinical presentations and diagnostic methods for tuberculosis in a cohort of HIV-infected infants, children and adolescents from Latin America.

methodsA retrospective analysis of children with tuberculosis and HIV was performed within a prospective observational cohort study conducted at multiple clinical sites in Latin America.

resultsOf 1114 HIV-infected infants, children, and adolescents followed from 2002 to 2011, 69 that could be classified as having confirmed or presumed tuberculosis were included in this case series; 52.2% (95% CI: 39.8-64.4%) had laboratory-confirmed tuberculosis, 15.9% (95% CI: 8.2-26.7%) had clinically confirmed disease and 31.9% (95% CI: 21.2-44.2%) had presumed tuberculosis. Sixty-six were perinatally HIV-infected. Thirty-two (61.5%) children had a history of contact with an adult tuberculosis case; however information on exposure to active tuberculosis was missing for 17 participants. At the time of tuberculosis diagnosis, 39 were receiving antiretroviral therapy. Sixteen of these cases may have represented immune reconstitution inflammatory syndrome.

conclusionsOur study emphasizes the need for adequate contact tracing of adult tuberculosis cases and screening for HIV or tuberculosis in Latin American children diagnosed with either condition. Preventive strategies in tuberculosis-exposed, HIV-infected children should be optimized.

Indexed as

AdolescentAIDS-Related Opportunistic InfectionsCD4 Lymphocyte CountChildChild, PreschoolFemaleHumansInfantInfant, NewbornLatin AmericaMaleProspective StudiesRetrospective StudiesRisk FactorsTuberculosis, PulmonaryYoung AdultChildrenHIVLatin AmericaTuberculosis

Identifiers

PMID25307683
PMCPMC4959272

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.