ReviewJournal of industrial microbiology & biotechnology2015
Recent advances in biosynthesis of fatty acids derived products in Saccharomyces cerevisiae via enhanced supply of precursor metabolites.
Review in Journal of industrial microbiology & biotechnology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 46 citations in OpenAlex.
- Spatiotemporal Metabolome analysis reveals a metabolic network during development of the waxy sorghum landrace 'Hongyingzi'.Frontiers in plant science · 2026Article
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- Synergistic increase in coproporphyrin III biosynthesis by mitochondrial compartmentalization in engineeredSynthetic and systems biotechnology · 2024Article
- CRISPR-Cas9-based genome-editing technologies in engineering bacteria for the production of plant-derived terpenoids.Engineering microbiology · 2024Review
- Genome-scale metabolic modeling reveals metabolic trade-offs associated with lipid production in Rhodotorula toruloides.PLoS computational biology · 2023Article
- Quantitative and modularized CRISPR/dCas9-dCpf1 dual function system inFrontiers in bioengineering and biotechnology · 2023Article
- Expression of Yarrowia lipolytica acetyl-CoA carboxylase in Saccharomyces cerevisiae and its effect on in-vivo accumulation of Malonyl-CoA.Computational and structural biotechnology journal · 2022Article
- EngineeredBioengineered · 2020Review
- Combinatorial metabolic engineering using an orthogonal tri-functional CRISPR system.Nature communications · 2017Article
- Microbial alkane production for jet fuel industry: motivation, state of the art and perspectives.Microbial biotechnology · 2017Review
- Metabolic Engineering of Oleaginous Yeasts for Production of Fuels and Chemicals.Frontiers in microbiology · 2017Review
- Improving acetyl-CoA biosynthesis inBiotechnology for biofuels · 2017Article
- Improved ethyl caproate production of Chinese liquor yeast by overexpressing fatty acid synthesis genes with OPI1 deletion.Journal of industrial microbiology & biotechnology · 2016Article
- Alternative reactions at the interface of glycolysis and citric acid cycle in Saccharomyces cerevisiae.FEMS yeast research · 2016Article
- Metabolic engineering of Saccharomyces cerevisiae for production of fatty acid short- and branched-chain alkyl esters biodiesel.Biotechnology for biofuels · 2015Article
- Metabolic engineering of yeast to produce fatty acid-derived biofuels: bottlenecks and solutions.Frontiers in microbiology · 2015Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fatty acids or their activated forms, fatty acyl-CoAs and fatty acyl-ACPs, are important precursors to synthesize a wide variety of fuels and chemicals, including but not limited to free fatty acids (FFAs), fatty alcohols (FALs), fatty acid ethyl esters (FAEEs), and alkanes. However, Saccharomyces cerevisiae, an important cell factory, does not naturally accumulate fatty acids in large quantities. Therefore, metabolic engineering strategies were carried out to increase the glycolytic fluxes to fatty acid biosynthesis in yeast, specifically to enhance the supply of precursors, eliminate competing pathways, and bypass the host regulatory network. This review will focus on the genetic manipulation of both structural and regulatory genes in each step for fatty acids overproduction in S. cerevisiae, including from sugar to acetyl-CoA, from acetyl-CoA to malonyl-CoA, and from malonyl-CoA to fatty acyl-CoAs. The downstream pathways for the conversion of fatty acyl-CoAs to the desired products will also be discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.