ArticleUrology2014
Secondarily infected nonstruvite urolithiasis: a prospective evaluation.
Article in Urology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association of Kidney Stones and Recurrent UTIs: the Chicken and Egg Situation. A Systematic Review of Literature.Current urology reports · 2022Pooled it
- Sex Differences in Admission Urine Culture Positivity, Pathogen Distribution, and Clinical Characteristics Among Patients with Calcium Oxalate Stones.Pathogens (Basel, Switzerland) · 2026Article
- Urinary Tract Infection in Patients with Urolithiasis: A Large Retrospective Observational Study of Clinical Features and Microbiological Spectrum.Pathogens (Basel, Switzerland) · 2026Observational
- Unravelling the Added Value of Urinary Stone Cultures Towards Infectious Complications Following Treatment of Renal Stones.Antibiotics (Basel, Switzerland) · 2026Article
- Comparison of the microbiome of bladder urine, upper urinary tract urine, and kidney stones in patients with urolithiasis.Central European journal of urology · 2025Article
- The immune factors have complex causal regulation effects on kidney stone disease: a mendelian randomization study.BMC immunology · 2024Article
- Association between urinary lithiasis, other than struvite by crystallography and non-ureolytic bacteria.Urolithiasis · 2024Article
- Gender differences in the microbial spectrum and antibiotic sensitivity of uropathogens isolated from patients with urinary stones.Journal of clinical laboratory analysis · 2022Article
- Recent advances on the mechanisms of kidney stone formation (Review).International journal of molecular medicine · 2021Review
- Human kidney stones: a natural record of universal biomineralization.Nature reviews. Urology · 2021Review
- Identifying Two Novel Clusters in Calcium Oxalate Stones With Urinary Tract Infection Using 16S rDNA Sequencing.Frontiers in cellular and infection microbiology · 2021Article
- Bacteriological Profile of Urine in Patients with Different Types of Kidney Stones in a Tertiary Care Hospital: A Descriptive Cross-sectional Study.JNMA; journal of the Nepal Medical Association · 2020Article
- Treatment of non-obstructive, non-struvite urolithiasis is effective in treatment of recurrent urinary tract infections.World journal of urology · 2020Article
- Urinary Calculi: A Microbiological and Biochemical Analysis at a Tertiary Care Hospital in Eastern Nepal.International journal of microbiology · 2020Article
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Authors and funding
5 authors.
Funding
Abstract
objectiveTo characterize patients who form nonstruvite stones associated with infection (secondarily infected calculi), and to define the bacteria associated with these. MATERIALS AND
methodsPatients undergoing percutaneous nephrolithotomy were prospectively recruited. Medical records were reviewed, and stones were analyzed using micro computed tomography and infrared spectroscopy. A fragment of each stone was sent for bacterial culture. Patients were categorized by stone culture results (SC ±) and the presence of struvite (ST ±). The Fisher exact test was used for comparison of proportion. Sterility of intraoperative SC was established with independently collected controls.
resultsIn total, 125 patients were enrolled: 24 SC+/ST-, 19 SC+/ST+, and 82 SC-/ST-. Proportions of patients with prior urologic surgery, diabetes, and immunodeficiency were similar between groups. Patients with neurogenic bladder were more likely to have SC+/ST+ stones or SC+/ST- stones than SC-/ST- stones (26% vs 8% vs 0%, respectively; P <.01). Among patients with metabolic evaluations, hypocitraturia was found in 31.6% (6 of 19) SC+/ST- patients, 46.7% (7 of 15) SC+/ST+ patients, and 26.0% (19 of 73) of SC-/ST- patients (P = .28). Approximately 40% of cultured organisms in the secondarily infected calculi possessed urease and another 40% citrate lyase activities.
conclusionSecondarily infected stones were detected in approximately 20% of this surgical cohort and may be more common than previously appreciated. Neurogenic bladder appeared to predispose patients to either struvite or secondarily infected stones. The role of bacterial infection in stone formation is unclear but may include alteration of urinary components, acting as a nidus for crystallization, or inducing inflammation.
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