Evidence map›Paper›PMID 25306217›Full record

ArticlePsychoneuroendocrinology2015

Hypothalamic vasopressin systems are more sensitive to the long term effects of social defeat in males versus females.

M Q Steinman, S A Laredo, E M Lopez, C E Manning, R C Hao, I E Doig, K L Campi, A E Flowers, J K Knight, B C Trainor

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychoneuroendocrinology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
10.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.

  1. Pooled it
  2. Autoantibodies reactive to adrenocorticotropic hormone can alter cortisol secretion in both aggressive and nonaggressive humans.Proceedings of the National Academy of Sciences of the United States of America · 2018
    Trial
  3. Neural basis of social hierarchy across species.Nature reviews. Neuroscience · 2026
    Review
  4. Article
  5. Article
  6. Oxytocin, Vasopressin and Stress: A Hormetic Perspective.Current issues in molecular biology · 2025
    Review
  7. Sexual differentiation of neural mechanisms of stress sensitivity during puberty.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  8. Article
  9. Article
  10. Review
  11. Mean Girls: Social Stress Models for Female Rodents.Current topics in behavioral neurosciences · 2022
    Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Oxytocin/vasopressin-like peptide inotocin regulates cuticular hydrocarbon synthesis and water balancing in ants.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  17. Article
  18. Sex-dependent regulation of social reward by oxytocin: an inverted U hypothesis.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

M Q SteinmanMolecular, Cellular and Integrative Physiology Graduate Group, University of California, Davis, CA 95616, USA; Department of Psychology, University of California, Davis, CA 95616, USA. Electronic address: ms8792@nyu.edu.
S A LaredoAnimal Behavior Graduate Group, University of California, Davis, CA 95616, USA; Department of Psychology, University of California, Davis, CA 95616, USA.
E M LopezDepartment of Psychology, University of California, Davis, CA 95616, USA.
C E ManningDepartment of Psychology, University of California, Davis, CA 95616, USA.
R C HaoDepartment of Psychology, University of California, Davis, CA 95616, USA.
I E DoigDepartment of Psychology, University of California, Davis, CA 95616, USA.
K L CampiDepartment of Psychology, University of California, Davis, CA 95616, USA.
A E FlowersMolecular, Cellular and Integrative Physiology Graduate Group, University of California, Davis, CA 95616, USA.
J K KnightDepartment of Psychology, University of California, Davis, CA 95616, USA.
B C TrainorMolecular, Cellular and Integrative Physiology Graduate Group, University of California, Davis, CA 95616, USA; Animal Behavior Graduate Group, University of California, Davis, CA 95616, USA; Department of Psychology, University of California, Davis, CA 95616, USA; Center for Neuroscience, University of California, Davis, CA 95616, USA. Electronic address: bctrainor@ucdavis.edu.
University of California, Davis · US

Funding

Neurpsychopharmacology-Multidisciplinary TrainingT32AA007456 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI MARISA ROBERTO · 1985 to 2026
$13.4M
Environmental regulation of estrogen dependent aggressionR01MH085069 · NIMH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI TRAINOR, BRIAN C · 2010 to 2013
$1.4M
Sex Differences in the Roles of Oxytocin and Vasopressin in Social WithdrawalF31MH095253 · NIMH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI STEINMAN, MICHAEL Q. · 2011 to 2014
$93k
NIAAA NIH HHS T32 AA007456NIMH NIH HHS F31 MH095253NIMH NIH HHS R01 MH085069
6 · The paper itself

Abstract

Vasopressin signaling has important effects on the regulation of social behaviors and stress responses, and is considered a promising pathway to target for new therapeutics of stress-induced psychiatric disorders. Although there is evidence for sex differences in the behavioral effects of arginine vasopressin (AVP), few data have directly compared the effects of stress on endogenous AVP signaling in males and females. We used California mice (Peromyscus californicus) to study the short and long term effects of social defeat stress on AVP immunoreactive cells in the paraventricular nucleus (PVN) and the posteromedial bed nucleus of the stria terminalis (BNSTmp). Acute exposure to defeat increased AVP/c-fos cells in the PVN and SON of both males and females. In contrast, there were sex differences in the long term effects of defeat. Males but not females exposed to defeat had less avp mRNA in the PVN, and in two experiments defeat reduced the number of AVP positive cells in the caudal PVN of males but not females. Interestingly, during relatively benign social encounters with a target mouse, there was a rapid decrease in AVP percent staining (including cell bodies and fibers) in the PVN of males but not females. Defeat reduced AVP percent staining in males, but did not block the socially induced decrease in percent staining. When mice were tested in resident-intruder tests, males exposed to defeat were no less aggressive than control males whereas aggression was abolished in females. However, bouts of aggression were positively correlated with the number of AVP neurons in the BNSTmp of control males but not stressed males, suggesting that different mechanisms mediate aggression in control and stressed males. These data show that while acute AVP responses to defeat are similar in males and females, the long term effects of defeat on AVP are stronger in males.

Indexed as

Sex CharacteristicsSocial BehaviorAnimalsArginine VasopressinFemaleMaleParaventricular Hypothalamic NucleusPeromyscusSeptal NucleiSocial DominanceStress, PsychologicalSupraoptic NucleusArginine VasopressinAggressionConditioned defeatHypothalamusOxytocinPeromyscusSex differencesSocial defeatStressVasopressin

Identifiers

PMID25306217
PMCPMC4268083
OpenAlexW2126400777

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.