ArticleThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2015
Hippocampal atrophy varies by neuropsychologically defined MCI among men in their 50s.
Article in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- The effect of a high-polyphenol Mediterranean diet (Green-MED) combined with physical activity on age-related brain atrophy: the Dietary Intervention Randomized Controlled Trial Polyphenols Unprocessed Study (DIRECT PLUS).The American journal of clinical nutrition · 2022Trial
- Mapping Divergent Subfield-Specific Hippocampal Degeneration in Mild Cognitive Impairment Continuum: Volumetric, Cognitive, and Genetic Predictors of Accelerated Hippocampal Biological Aging.CNS neuroscience & therapeutics · 2025Article
- The prefrontal cortex, but not the medial temporal lobe, is associated with episodic memory in middle-aged persons with HIV.Journal of the International Neuropsychological Society : JINS · 2024Article
- Effects of sleep deprivation on brain atrophy in individuals with mild cognitive impairment and Alzheimer's disease.Ageing research reviews · 2024Article
- Rostral-middle locus coeruleus integrity and subjective cognitive decline in early old age.Journal of the International Neuropsychological Society : JINS · 2023Article
- Lifestyle and the aging brain: interactive effects of modifiable lifestyle behaviors and cognitive ability in men from midlife to old age.Neurobiology of aging · 2021Article
- How Well Does Subjective Cognitive Decline Correspond to Objectively Measured Cognitive Decline? Assessment of 10-12 Year Change.Journal of Alzheimer's disease : JAD · 2021Article
- Association of baseline semantic fluency and progression to mild cognitive impairment in middle-aged men.Neurology · 2020Article
- Posttraumatic stress symptom persistence across 24 years: association with brain structures.Brain imaging and behavior · 2020Article
- Extensive memory testing improves prediction of progression to MCI in late middle age.Alzheimer's & dementia (Amsterdam, Netherlands) · 2020Article
- Underdiagnosis of mild cognitive impairment: A consequence of ignoring practice effects.Alzheimer's & dementia (Amsterdam, Netherlands) · 2018Article
- Task-evoked pupil dilation and BOLD variance as indicators of locus coeruleus dysfunction.Cortex; a journal devoted to the study of the nervous system and behavior · 2017Article
- Structural Image Analysis of the Brain in Neuropsychology Using Magnetic Resonance Imaging (MRI) Techniques.Neuropsychology review · 2015Review
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Authors and funding
16 authors at 6 institutions in 2 countries.
Funding
Abstract
objectiveIn an effort to address earliest detection of mild cognitive impairment (MCI), we examined hippocampal volumes and atrophy in middle-aged men to explore neuroanatomical support for different neuropsychological definitions of MCI.
methods460 men aged 51-60 years underwent neuropsychological testing and MRI. MCI was defined according to five criteria sets. MRI-derived hippocampal volume and hippocampal occupancy (HOC) were obtained via FreeSurfer. Statistical analyses were performed using linear mixed models.
resultsDifferences in HOC between normal cognitive functioning, amnestic, and non-amnestic MCI were observed using MCI criteria that required one impaired (>1.5 SD) cognitive measure in a given cognitive domain or a cognitive composite score method with a cut-point 2 SD below the mean. Differences in standard hippocampal volume were only found between normal and amnestic presentations and only when using the composite score method.
conclusionResults provide empirical support for detection of pre-MCI in younger cohorts. Convergence of neuropsychological and neuroanatomical data, particularly HOC (as opposed to standard cross-sectional volume), supports early identification of MCI as defined by some neuropsychological criteria.
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